Miniaturized sub-nanoampere sensitivity low-noise potentiostat system

• US 9,933,387 B1
• Filed: 09/02/2015
• Issued: 04/03/2018
• Est. Priority Date: 09/07/2014
• Status: Active Grant

• Current Assignee: Biolinq Incorporated
• Original Assignee: Biolinq Incorporated
• Inventors: McCanna, James, Windmiller, Joshua
• Primary Examiner(s): Ball, J. Christopher
• Application Number:
  US14/843,926
• Time in Patent Office: 944 Days
• CPC Class Codes: G01N 27/286 Power or signal connectors associated therewith
• CPC Class Codes: G01N 27/3273 Devices therefor, e.g. test element readers, circuitry details not specific to biochemical electrodes G01N33/4875
• CPC Class Codes: G01N 27/416 Systems G01N27/27 takes precedence

Abstract

A miniaturized sub-nanoampere sensitivity low-noise potentiostat system is disclosed herein. The system includes an adjustable bias analog front end/potentiostat, a plurality of high input impedance and high gain difference amplifiers, means for signal filtering, a high-resolution analog-to-digital converter, and a sampling algorithm.

Claims

1. An analyzer for the detection of low concentrations of analytes, the analyzer comprising:

an adjustable bias analog front end comprising a plurality of high-input impedance operational amplifiers and a digital-to-analog converter;

an adjustable low noise transimpedance amplifier;

a mirrored high input impedance and high gain difference amplifier;

a processor;

a filtering circuit configured to filter a signal;

a high-resolution analog-to-digital converter; and

a sampling algorithm.

2. The analyzer according claim 1 wherein the processor is configured to run a subtraction algorithm for reduction of noise and removal of fluctuations in the signal.

3. The analyzer according to claim 1 wherein the analyzer does not include an off-board shielding element.

4. The analyzer according to claim 1 further comprising an analog-to-digital converter.

5. The analyzer according to claim 1 wherein the processor is configured to run a time average hardware filtering and a sampling algorithm to stabilize a plurality of readings and to eliminate a plurality of interfering signal harmonics.

6. The analyzer according to claim 1 wherein the processor is configured to run a collection algorithm.

7. The analyzer according to claim 1 wherein the analyzer is sensitive to detection of a current within a range of 1 pico Amperes to 700 micro Amperes.

8. The analyzer according to claim 1 wherein the filtering circuit comprises a combination of at least one of a high pass filter, a band pass filter, a passive low pass filter, and an active filter.

9. The analyzer according to claim 1 wherein the analyzer is for at least one of detection of extremely low currents, potentiometry, coulometry, polarography, conductometry, impedimetry, amperometry and voltammetry.