Pulse period calculation device and biosensor equipped with the same

• US 9,936,888 B2
• Filed: 04/10/2013
• Issued: 04/10/2018
• Est. Priority Date: 10/14/2010
• Status: Active Grant

• Current Assignee: Murata Manufacturing Co Limited
• Original Assignee: Murata Manufacturing Co Limited
• Inventors: Okuda, Noriaki, Takahasi, Eiji
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): GHAND, JENNIFER LEIGH-STEWAR
• Application Number:
  US13/860,241
• Publication Number:
  US 20130267859A1
• Time in Patent Office: 1,826 Days
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/0245 by using sensing means generating electric signals, i.e. ECG signals
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

A device for calculating a pulse period of a living body. The device includes a maximum value detecting unit that detects a maximum value of a biological signal received at a predetermined time interval, a peak value determining unit that determines whether the maximum value is a peak value of the biological signal detected by the maximum value detecting unit during a fixed time period, a calculating unit that calculates a rhythmic pulse period of a living body generating the biological signal based on a time interval between successive peak values of the biological signal; and a fixed time period changing unit that changes the fixed time period to a predetermined time period that corresponds to the time interval between the successive peak values of the biological signal.

Claims

1. A pulse period calculation device for calculating a rhythmic pulse period of a living body, the device comprising:

a maximum value detecting unit configured to determine a maximum value of a biological signal of the living body by detecting a highest value of the biological signal during a predetermined time interval and selecting the highest value of the biological signal as the maximum value;

a peak value determining unit configured to determine that the determined maximum value is a peak value of the biological signal when the maximum value detecting unit does not detect a new value of the biological signal during a fixed time period following the determined maximum value that is greater than the highest value of the biological signal selected as the determined maximum value;

a calculating unit configured to calculate the rhythmic pulse period of the living body based on a measured time interval between successive peaks of the determined peak value of the biological signal when the measured time interval between the successive peaks is greater than the fixed time period; and

a fixed time period changing unit configured to select, as an updated fixed time period, one of a plurality of predetermined time periods based on the measured time interval between the successive peaks of the determined peak value of the biological signal,

wherein, when the maximum value detecting unit determines that the highest value of the biological signal detected during the updated fixed time period following a current peak value of the biological signal is greater than the determined maximum value, the peak value determining unit updates the peak value of the biological signal to be the highest value of the biological signal detected during the updated fixed time period, and

wherein the calculating unit is further configured to update the rhythmic pulse period based on a measured time interval between successive peaks of the updated peak value when the measured time interval between the successive peaks of the updated peak value is greater than the updated fixed time period.

2. The pulse period calculation device according to claim 1, wherein the fixed time period changing unit is further configured to successively change the updated fixed time period when the successive peaks of the determined peak value each fall within a predetermined range.

3. The pulse period calculation device according to claim 1, wherein the biological signal is a heartbeat signal of the living body and the rhythmic pulse period is a heart rate of the living body.

4. The pulse period calculation device according to claim 1, wherein the biological signal is a pulse wave signal and the rhythmic pulse period is a pulse rate.

5. The pulse period calculation device according to claim 1,

wherein the maximum value detecting unit comprises:

a heartbeat maximum value detecting unit configured to detect a maximum value of a heartbeat signal received at the predetermined time interval, and

a pulse wave maximum value detecting unit configured to detect a maximum value of an acceleration pulse wave signal obtained by subjecting a pulse wave signal measured at the predetermined time interval to differentiation two times, wherein the peak value determining unit comprises;

a heartbeat peak value determining unit configured to determine whether the detected maximum value of the heartbeat signal is a heartbeat peak value detected by the heartbeat maximum value detecting unit during the fixed time period, and

a pulse wave peak value determining unit configured to determine whether the detected maximum value of the acceleration pulse wave signal is an acceleration pulse wave peak value,

wherein the calculating unit is further configured to calculate a pulse wave propagation time period from a time difference between the heartbeat peak value and the acceleration pulse wave peak value, and

wherein the fixed time period changing unit is further configured to successively change the fixed time period used for heartbeat peak value determination to one of a plurality of predetermined time periods that corresponds to the time interval between the heartbeat peak values, and to successively change the fixed time period for acceleration pulse wave peak value determination to one of a plurality of predetermined time periods that corresponds to the time interval between the acceleration pulse wave peak values.

6. The pulse period calculation device according to claim 1, further comprising:

an amplifying unit configured to amplify the biological signal at an amplification ratio according to a control signal and to output the amplified signal to the maximum value detecting unit; and

a reference value detecting unit configured to detect a magnitude of the amplified biological signal at a predetermined timing as a reference value,

wherein the calculating unit is further configured to calculate a magnitude of the determined peak value of the biological signal based on a difference between the peak value of the biological signal and the reference value and to output to the amplifying unit the control signal, which is based on the magnitude of the determined peak value of the biological signal.

7. The pulse period calculation device according to claim 6, wherein the biological signal is composed of a P wave, a Q wave, an R wave, an S wave, a T wave and a U wave, and the predetermined timing is based on an ST segment of the biological signal.

8. The pulse period calculation device according to claim 6, wherein the calculating unit is further configured to calculate respective magnitudes of peak values based on differences between a plurality of successive peak values of the biological signal and a plurality of reference values that correspond to the plurality of successive peak values, respectively, and to change the control signal when the calculated respective magnitudes of the peak values are successively within a predetermined range.

9. The pulse period calculation device according to claim 1, wherein the peak value determining unit is further configured to determine that the determined maximum value is the peak value of the biological signal when the determined maximum value is larger than or equal to a previous peak value of the rhythmic pulse stored in memory minus a fixed value and when the maximum value detecting unit does not detect a new value of the biological signal during the fixed time period following the determined maximum value that is greater than the highest value of the biological signal.

10. The pulse period calculation device according to claim 1, wherein the peak value determining unit is further configured to determine that the determined maximum value is the peak value of the biological signal when the determined maximum value is determined to be a normal peak value and when the maximum value detecting unit does not detect a new value of the biological signal during the fixed time period following the determined maximum value that is greater than the highest value of the biological signal.

11. A bio-sensor comprising the pulse period calculation device according to claim 1.

12. A pulse period calculation device for calculating a rhythmic pulse period of a living body, the pulse period calculation device comprising a processor configured to:

determine a maximum value of a biological signal of the living body by detecting a highest value of the biological signal during a predetermined time interval and selecting the highest value of the biological signal as the maximum value;

determine that the determined maximum value is a peak value of the biological signal when a new value of the biological signal is not detected during a fixed time period following the determined maximum value that is greater than the highest value of the biological signal selected as the determined maximum value;

calculate the rhythmic pulse period of the living body based on a measured time interval between successive peaks of the determined peak value of the biological signal when the measured time interval between the successive peaks is greater than the fixed time period;

select, as an updated fixed time period, one of a plurality of predetermined time periods as a changed fixed time period based on the measured time interval between the successive peaks of the determined peak value of the biological signal;

update the peak value of the biological signal to be the highest value of the biological signal detected during the updated fixed time period when the highest value of the biological signal detected during the updated fixed time period following a current peak value of the biological signal is greater than the determined maximum value detected at the fixed time period; and

update the rhythmic pulse period based on a measured time interval between successive peaks of the updated peak value when the measured time interval between the successive peaks of the updated peak value is greater than the updated fixed time period.

13. The pulse period calculation device according to claim 12, wherein the processor is further configured to successively change the updated fixed time period when the successive peaks of the determined peak value each fall within a predetermined range.

14. The pulse period calculation device according to claim 12, further comprising:

an amplifying unit configured to amplify the biological signal at an amplification ratio according to a control signal and to output the amplified signal to the processor,

wherein the processor is further configured to detect a magnitude of the amplified biological signal at a predetermined timing as a reference value, to calculate a magnitude of the determined peak value of the biological signal based on a difference between the peak value of the biological signal and the reference value, and to output to the amplifying unit the control signal, which is based on the magnitude of the determined peak value of the biological signal.

15. The pulse period calculation device according to claim 14, wherein the processor is further configured to calculate respective magnitudes of peak values based on differences between a plurality of successive peak values of the biological signal and a plurality of reference values that correspond to the plurality of successive peak values, respectively, and to change the control signal when the calculated respective magnitudes of the peak values are successively within a predetermined range.

16. A pulse period calculation method for calculating a rhythmic pulse period of a living body, the method comprising:

determining a first maximum value of a biological signal of the living body by detecting a highest value of the biological signal during a predetermined time interval and selecting the highest value of the biological signal as the maximum value;

determining that the determined maximum value is a peak value of the biological signal when a new value of the biological signal is not detected during a fixed time period following the determined maximum value that is greater than the highest value of the biological signal selected as the determined maximum value;

calculating the rhythmic pulse period of the living body based on a measured time interval between successive peaks of the determined peak value of the biological signal when the measured time interval between the successive peaks is greater than the fixed time period; and

selecting, as an updated fixed time period, one of a plurality of predetermined time periods based on the measured time interval between the successive peaks of the determined peak value of the biological signal;

updating the peak value of the biological signal to be the highest value of the biological signal detected during the updated fixed time period when the highest value of the biological signal detected during the updated fixed time period following a current peak value of the biological signal is greater than the determined maximum value detected at the fixed time period; and

updating the rhythmic pulse period based on a measured time interval between successive peaks of the updated peak value when the measured time interval between the successive peaks of the updated peak value is greater than the updated fixed time period.

17. The pulse period calculation method according to claim 16, further comprising:

successively changing the updated fixed time period when the successive peaks of the determined peak value each fall within a predetermined range.

18. The pulse period calculation method according to claim 16, further comprising:

amplifying the biological signal at an amplification ratio according to a control signal;

detecting a magnitude of the amplified biological signal at a predetermined timing as a reference value;

calculating a magnitude of the determined peak value of the biological signal based on a difference between the peak value of the biological signal and the reference value; and

adjusting the control signal based on the magnitude of the determined peak value of the biological signal.

19. The pulse period calculation method according to claim 18, further comprising:

calculating respective magnitudes of peak values based on differences between a plurality of successive peak values of the biological signal and a plurality of reference values that correspond to the plurality of successive peak values, respectively; and

changing the control signal when the calculated respective magnitudes of the peak values are successively within a predetermined range.