Zwitterion surface modifications for continuous sensors
First Claim
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1. A device for measurement of a glucose concentration, the device comprising:
- a sensor configured to generate a signal indicative of a glucose concentration; and
a sensing membrane located over the sensor, wherein the sensing membrane comprises an outermost domain, wherein the outermost domain is configured to interface with a biological fluid when implanted in a host, wherein the outermost domain comprises a polyurethane copolymer, wherein the copolymer comprises at least one betaine compound or a derivative thereof, wherein the at least one betaine compound or a derivative thereof comprises 0.1 to 5% by weight of the outermost domain, and wherein the polyurethane copolymer comprises both hydrophilic and hydrophobic regions.
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Abstract
Devices are provided for measurement of an analyte concentration, e.g., glucose in a host. The device can include a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises a diffusion resistance domain configured to control a flux of the analyte therethrough. The diffusion resistance domain comprises one or more zwitterionic compounds and a base polymer comprising both hydrophilic and hydrophobic regions.
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Citations
11 Claims
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1. A device for measurement of a glucose concentration, the device comprising:
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a sensor configured to generate a signal indicative of a glucose concentration; and a sensing membrane located over the sensor, wherein the sensing membrane comprises an outermost domain, wherein the outermost domain is configured to interface with a biological fluid when implanted in a host, wherein the outermost domain comprises a polyurethane copolymer, wherein the copolymer comprises at least one betaine compound or a derivative thereof, wherein the at least one betaine compound or a derivative thereof comprises 0.1 to 5% by weight of the outermost domain, and wherein the polyurethane copolymer comprises both hydrophilic and hydrophobic regions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification