Iontophoretic contact lens
First Claim
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1. A contact lens for ocular therapy, comprising:
- a reservoir containing a charged therapeutic composition;
a current source providing iontophoretic current to the charged therapeutic composition to affect delivery of the charged therapeutic composition into an eyeball;
a sensing circuit controlling the current source to maintain a selected pH range of the charged therapeutic composition; and
a polarity selective barrier region disposed at a perimeter of the reservoir and having a polarity the same as that of the charged composition in the corresponding reservoir.
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Abstract
Contact lenses are provided for ocular iontophoretic therapy. Implementations include a reservoir adapted to contain a charged therapeutic compound, a current source providing iontophoretic current to the charged therapeutic composition to affect delivery of the charged therapeutic composition into an eyeball, and a sensing circuit controlling the current source to maintain a selected pH range of the charged therapeutic composition. Alternate embodiments include active, sacrificial electrodes for generating ions sufficient to provide electromotive repulsive force to the charged compound to effect transport into ocular tissue.
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Citations
12 Claims
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1. A contact lens for ocular therapy, comprising:
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a reservoir containing a charged therapeutic composition; a current source providing iontophoretic current to the charged therapeutic composition to affect delivery of the charged therapeutic composition into an eyeball; a sensing circuit controlling the current source to maintain a selected pH range of the charged therapeutic composition; and a polarity selective barrier region disposed at a perimeter of the reservoir and having a polarity the same as that of the charged composition in the corresponding reservoir. - View Dependent Claims (2, 3, 4, 5, 6, 7, 9, 10)
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8. A contact lens for ocular therapy, comprising:
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a reservoir containing a charged therapeutic composition; a current source providing iontophoretic current to the charred therapeutic composition to affect delivery of the charred therapeutic composition into an eyeball; and a sensing circuit controlling the current source to maintain a selected pH range of the charged therapeutic composition, wherein the sensing circuit comprises; a pH sensor configured to detect the pH level of the charge therapeutic composition; and a current source controller configured to change the iontophoretic current when the detected pH level is outside the selected pH range a polarity selective barrier region disposed at a perimeter of the reservoir having a polarity the same as that of the charged composition in the corresponding reservoir.
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11. A contact lens for ocular therapy, comprising:
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a reservoir adapted to contain a charged therapeutic compound; a sacrificial electrode with a sacrificial element in contact with the charged therapeutic compound, the sacrificial electrode adapted to generate ions having the same charge polarity as the charged therapeutic compound through consuming the sacrificial element; a voltage source providing iontophoretic voltage to the sacrificial electrode to affect an electric motive force causing delivery of the charged therapeutic compound into an eyeball; and a sensing circuit controlling the voltage source to adjust the delivery of the charged therapeutic compound. - View Dependent Claims (12)
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Specification