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Trilayer coated pharmaceutical packaging with low oxygen transmission rate

  • US 9,937,099 B2
  • Filed: 06/26/2015
  • Issued: 04/10/2018
  • Est. Priority Date: 03/11/2013
  • Status: Active Grant
First Claim
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1. A vessel comprising:

  • a thermoplastic wall;

    defining a lumen,having an interior surface facing the lumen, andhaving a first oxygen transmission rate respecting ingress of oxygen;

    a coating set on the interior surface, comprising;

    a tie coating or layer having an interior surface facing the lumen and an outer surface facing the wall interior surface;

    a barrier coating or layer having an outer surface facing the wall interior surface and, if present, the interior surface of the tie coating or layer;

    and a pH protective coating or layer having an interior surface facing the lumen and an outer surface facing the interior surface of the barrier coating or layer;

    in which the barrier coating or layer is effective to provide a second oxygen transmission rate lower than the first oxygen transmission rate;

    in which the coating set on the interior surface is effective to maintain the second oxygen transmission rate lower than the first oxygen transmission rate for at least six months of contact between a fluid in the lumen having a pH from 3 to 9 and the pH protective coating or layer.

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