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Polymeric treatment compositions

  • US 9,937,201 B2
  • Filed: 04/29/2016
  • Issued: 04/10/2018
  • Est. Priority Date: 06/14/2012
  • Status: Active Grant
First Claim
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1. A method of delivering a composition comprising:

  • injecting through a delivery device into a location with physiological pH environment a liquid embolic composition comprising a biocompatible polymer, an aqueous solution with a non-physiological pH, and a visualization agent, wherein the visualization agent is an iodinated compound, barium sulfate tantalum, superparamagnetic iron oxide, gadolinium molecules, or a combination thereof,wherein the biocompatible polymer is soluble in the aqueous solution and precipitates when it reaches the physiological pH and wherein the biocompatible polymer comprises;

    a first monomer selected from a group consisting of aminopropyl methacrylamide, aminoethyl methacrylamide, N-(3-methylphridine)acrylamide, N-(2-(4-aminophenyl)ethylacrylamide, N-(4-aminobenzyl)acrylamide, N-(2-4-imidazolyl)ethyl)acrylamide, and combinations thereof; and

    a second monomer selected from a group consisting of t-butyl acrylate, t-butyl acrylamide, n-octyl methacrylate, methyl methacrylate, hydroxyethyl methacrylate, hydroxyethyl acrylate, hydroxypropyl methacrylate, hydroxybutyl methacrylate, derivatives thereof, or combinations thereof.

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