Inhibition of diacylglycerol kinase to augment adoptive T cell transfer
First Claim
1. A composition with enhanced cytolytic activity, said composition comprising an inhibitor of diacylglycerol kinase (DGK) or a downstream effector protein thereof and a T cell modified with a chimeric antigen receptor (CAR).
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention provides compositions and methods for inhibiting one or more diacylglycerol kinase (DGK) isoform in a cell in order to enhance the cytolytic activity of the cell. In one embodiment, the cells may be used in adoptive T cell transfer. For example, in some embodiments, the cell is modified to express a chimeric antigen receptor (CAR). Inhibition of DGK in T cells used in adoptive T cell transfer increases cytolytic activity of the T cells and thus may be used in the treatment of a variety of conditions, including cancer, infection, and immune disorders.
-
Citations
14 Claims
- 1. A composition with enhanced cytolytic activity, said composition comprising an inhibitor of diacylglycerol kinase (DGK) or a downstream effector protein thereof and a T cell modified with a chimeric antigen receptor (CAR).
- 7. An isolated T cell with enhanced cytolytic activity, wherein the T cell comprises an inhibitor of DGK or a downstream effector protein thereof and a chimeric antigen receptor (CAR).
Specification