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Engineering synthethic brain penetrating gene vectors

  • US 9,937,270 B2
  • Filed: 05/12/2015
  • Issued: 04/10/2018
  • Est. Priority Date: 05/12/2014
  • Status: Active Grant
First Claim
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1. A nanoparticle formulation for delivery of nucleic acid to tissue including brain, comprisingnucleic acids;

  • a first hydrophilic cationic polymer; and

    a second hydrophilic, neutrally charged linear or branched polymer selected from the group consisting of polyethylene glycol, polyethylene oxide, and copolymers thereof,wherein at least about 90% of the first hydrophilic cationic polymer is conjugated to the second hydrophilic, neutrally charged linear or branched polymer,wherein the nucleic acid is encapsulated within the nanoparticle or associated with the surface of the nanoparticle and wherein the nanoparticle is coated with the second hydrophilic, neutrally charged linear or branched polymer at a density that imparts a near neutral charge and enhances the diffusivity through the tissue.

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