Waveforms for electrical stimulation therapy

• US 9,937,344 B2
• Filed: 09/21/2010
• Issued: 04/10/2018
• Est. Priority Date: 09/21/2009
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Starkebaum, Warren L., Maude-Griffin, Roland C., Firestone, Elizabeth D., Schu, Carl A., Soykan, Orhan
• Primary Examiner(s): Wu, Eugene T
• Application Number:
  US12/887,149
• Publication Number:
  US 20110071589A1
• Time in Patent Office: 2,758 Days
• Field of Search: 607 40, 607 72, 607 74, 607133
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36085 Eating disorders or obesity
• CPC Class Codes: A61N 1/36171 Frequency
• CPC Class Codes: A61N 1/36175 Pulse width or duty cycle

Abstract

In some examples, the disclosure relates to a systems, devices, and techniques for delivering electrical stimulation therapy to a patient. In one example, the disclosure relates to a method including delivering a series of pulses with alternating pulse polarities to a gastrointestinal tract of a patient. The series of pulses includes at least a first pulse of a first polarity, a second pulse of a second polarity, and a third pulse of the first polarity, where the first, second and third pulses are delivered in direct succession and in that order. The first and second pulses are separated by a first time delay and the second and third pulses are separated by a second time delay. In some examples, each of the first and second time delays depend on the frequency that the series of pulses are delivered.

Claims

1. A method comprising controlling, via at least one processor, delivery from a medical device to a target location of a gastrointestinal (GI) tract of a patient of a sequence of pulses at a specified frequency, with each pulse having a single polarity, with all even numbered pulses in the sequence having one polarity and all odd numbered pulses in the sequence having an opposite polarity, in a fashion such that respective intervals between consecutive pulses in the sequence increases with decreases in the specified frequency of delivery, and decreases with increases in the specified frequency of delivery.

2. A medical device system comprising:

a stimulation generator configured to generate and deliver a series of pulses having alternating pulse polarities to a patient; and

a processor configured to control the series of pulses generated and delivered by the stimulation generator,

wherein the device is configured to deliver the series of pulses to a target location of a gastrointestinal (GI) tract of a patient, wherein each pulse having a single polarity, with all even numbered pulses in the sequence having one polarity and all odd numbered pulses in the sequence having an opposite polarity, in a fashion such that respective intervals between consecutive pulses in the sequence increases with decreases in the specified frequency of delivery, and decreases with increases in the specified frequency of delivery.

3. A non-transitory computer-readable storage medium comprising instructions to cause a programmable processor to control a stimulation generator to deliver a series of pulse pairs with alternating pulse polarities from a medical device to a target location of a gastrointestinal (GI) tract of a patient, wherein each pulse has a single polarity, with all even numbered pulses in the sequence having one polarity and all odd numbered pulses in the sequence having an opposite polarity, in a fashion such that respective intervals between consecutive pulses in the sequence increases with decreases in the specified frequency of delivery, and decreases with increases in the specified frequency of delivery.

4. A method comprising controlling, via at least one processor, delivery of a series of pulses with alternating pulse polarities from a medical device to a target location of a gastrointestinal (GI) tract of a patient, wherein the series of pulses includes at least a first pulse of a first polarity, a second pulse of a second polarity, a third pulse of the first polarity, and a fourth pulse of the second polarity, wherein the first, second, third and fourth pulses are delivered to the target location in direct succession, in that order, wherein the first pulse and second pulse are separated by a first time delay, the second pulse and third pulse are separated by a second time delay, the third pulse and the fourth pulse are separated by a third time delay, and wherein an increase in a pulse frequency of the series of pulses causes the first time delay, the second time delay, and third time delay to decrease in duration, and a decrease in the pulse frequency of the series of pulses causes the first time delay, the second time delay, and third time delay to increase.

5. The method of claim 4, wherein each pulse of the series of pulses has a pulse width between approximately 0.05 milliseconds and approximately 1000 milliseconds.

6. The method of claim 4, wherein the series of pulses are delivered at a pulse frequency between approximately 0.05 Hz and approximately 40 Hz.

7. The method of claim 4, wherein each pulse of the series of pulses has an amplitude greater than zero but less than or equal to approximately 25 volts.

8. The method of claim 4, wherein the series of pulses are delivered with a controlled current, and each pulse of the series of pulses has an amplitude greater than zero but less than or equal to approximately 25 milliamps.

9. The method of claim 4, wherein the first time delay and second time delay are approximately equal and vary with the pulse frequency.

10. The method of claim 4, wherein first, second, third, and fourth pulses have approximately the same charge amount.

11. The method of claim 4, wherein delivering the series of pulses with alternating pulse polarities to the target location of the gastrointestinal tract of the patient comprises delivering the series of pulses to a stomach of the patient.

12. The method of claim 11, wherein the delivery of the series of pulses to the stomach of the patient increases distention of the stomach of the patient.

13. The method of claim 4, further comprising identifying the patient as obese, wherein the electrical stimulation is delivered to the patient based at least in part on the identification.

14. The method of claim 4, further comprising adjusting an amplitude of one or more of the pulses of the series of pulses to maintain charge balance.

15. The method of claim 4, further comprising adjusting a pulse width of one or more of the pulses of the series of pulses to maintain charge balance.

16. The method of claim 4, further comprising increasing the pulse frequency of the series of pulses, wherein increasing the pulse frequency comprises decreasing the first time delay, the second time delay, and third time delay.

17. The method of claim 4, further comprising decreasing the pulse frequency of the series of pulses, wherein decreasing the pulse frequency comprises increasing the first time delay, the second time delay, and the third time delay.

18. The method of claim 4, wherein each pulse of the series of pulses has a pulse width between approximately 1 milliseconds and approximately 5 milliseconds.

19. The method of claim 4, wherein the series of pulses are delivered at a pulse frequency between approximately 1 Hz and approximately 40 Hz.

20. The method of claim 4, wherein the first time delay, second time delay, and third time delay are approximately equal.

21. The method of claim 4, wherein a fourth time delay follows the fourth pulse.

22. The method of claim 21, wherein the increase in the pulse frequency of the series of pulses causes the fourth time delay to decrease in duration, and the decrease in the pulse frequency of the series of pulses causes the fourth time delay to increase.

23. The method of claim 21, wherein the second time delay and the fourth time delay are approximately equal.

24. A medical device system comprising:

a stimulation generator configured to generate and deliver a series of pulses having alternating pulse polarities to a patient; and

a processor configured to control the series of pulses generated and delivered by the stimulation generator,

wherein the device is configured to deliver the series of pulses to a target location of a gastrointestinal (GI) tract of a patient, wherein the series of pulses includes at least a first pulse of a first polarity, a second pulse of a second polarity, a third pulse of the first polarity, and a fourth pulse of the second polarity, wherein the first, second, third and fourth pulses are delivered to the target location in direct succession, in that order, wherein the first pulse and second pulse are separated by a first time delay, the second pulse and third pulse are separated by a second time delay, the third pulse and the fourth pulse are separated by a third time delay, and wherein an increase in a pulse frequency of the series of pulses causes the first time delay, the second time delay, and third time delay to decrease in duration, and a decrease in the pulse frequency of the series of pulses causes the first time delay, the second time delay, and third time delay to increase.

25. The medical device system of claim 24, further comprising at least one elongated lead including at least one electrode, the at least one lead configured to be attached to a wall of the GI tract of the patient, wherein the at least one electrode delivers the series of pulses to the GI tract of the patient from the stimulation generator when the at least one lead is anchored to the wall of the GI tract of the patient.

26. The medical device system of claim 24, wherein the processor controls each pulse of the series of pulses to have a pulse width between approximately 0.05 milliseconds and approximately 1000 milliseconds.

27. The medical device system of claim 24, wherein the processor controls the series of pulses to be delivered at a pulse frequency between approximately 0.05 Hz and approximately 40 Hz.

28. The medical device system of claim 24, wherein the processor controls each pulse of the series of pulses to have an amplitude greater than zero but less than or equal to approximately 25 volts.

29. The medical device system of claim 24, wherein the processor controls each pulse of the series of pulses to have an amplitude greater than zero but less than or equal to approximately 25 milliamps.

30. The medical device system of claim 24, wherein the processor controls the series of pulses such that the first time delay and second time delay are approximately equal and vary with the pulse frequency.

31. The medical device system of claim 24, wherein the processor controls the first, second, third, and fourth pulses to have approximately the same charge amount.

32. The medical device system of claim 24, wherein delivering the series of pulses with alternating pulse polarities to the target location of the gastrointestinal tract of the patient comprises delivering the series of pulses to a stomach of the patient.

33. The medical device system of claim 30, wherein the delivery of the series of pulses to the stomach of the patient to increases distention of the stomach of the patient.

34. The medical device system of claim 24, wherein the processor is configured to identify the patient as obese, and wherein the processor controls the delivery of the series of pulses to the patient based at least in part on the identification.

35. The medical device system of claim 24, wherein the stimulation generator comprises an implantable stimulation generator.

36. The medical device system of claim 24, further comprising one or more implantable leads configured to deliver the series of pulses to the target location of the GI tract of the patient.

37. The medical device system of claim 24, wherein the processor is configured to control the series of pulses to increase the pulse frequency, wherein the increase in pulse frequency causes a decrease the first time delay, the second time delay, and third time delay.

38. The medical device system of claim 24, wherein the processor is configured to control the series of pulses to decrease the pulse frequency, wherein the decrease in pulse frequency causes an increase in the first time delay, the second time delay, and the third time delay.

39. The medical device system of claim 24, wherein the processor is configured to control each pulse of the series of pulses to have a pulse width between approximately 1 milliseconds and approximately 5 milliseconds.

40. The medical device system of claim 24, wherein the processor is configured to control the series of pulses to be delivered at a pulse frequency between approximately 1 Hz and approximately 40 Hz.

41. The medical device system of claim 24, wherein the processor is configured to control the series of pulses such that the first time delay, second time delay, and third time delay are approximately equal.

42. The medical device system of claim 24, wherein a fourth time delay follows the fourth pulse.

43. The medical device system of claim 42, wherein the increase in the pulse frequency of the series of pulses causes the fourth time delay to decrease in duration, and the decrease in the pulse frequency of the series of pulses causes the fourth time delay to increase.

44. The medical device system of claim 42, wherein the processor is configured to control the series of pulses such that the second time delay, and the fourth time delay are approximately equal.

45. A non-transitory computer-readable storage medium comprising instructions to cause a programmable processor to control a stimulation generator to deliver a series of pulses with alternating pulse polarities from a medical device to a target location of a gastrointestinal (GI) tract of a patient, wherein the series of pulses includes at least a first pulse of a first polarity, a second pulse of a second polarity, a third pulse of the first polarity, and a fourth pulse of the second polarity, wherein the first, second, third and fourth pulses are delivered to the target location in direct succession, in that order, wherein the first pulse and second pulse are separated by a first time delay, the second pulse and third pulse are separated by a second time delay, the third pulse and the fourth pulse are separated by a third time delay, and wherein an increase in a pulse frequency of the series of pulses causes the first time delay, the second time delay, and third time delay to decrease in duration, and a decrease in the pulse frequency of the series of pulses causes the first time delay, the second time delay, and third time delay to increase.

46. The non-transitory computer-readable storage medium of claim 45, wherein the first time delay, second time delay, and third time delay are approximately equal.

47. The non-transitory computer-readable storage medium of claim 45, wherein a fourth time delay follows the fourth pulse.