RF hyperthermia device for personalized treatment and diagnosis

• US 9,937,357 B2
• Filed: 08/27/2013
• Issued: 04/10/2018
• Est. Priority Date: 08/27/2012
• Status: Active Grant

• Current Assignee: XAX KFT.
• Original Assignee: XAX KFT.
• Inventors: Szasz, Oliver, Szasz, Andras, Iluri, Nora
• Primary Examiner(s): Cattungal, Sanjay
• Application Number:
  US14/424,025
• Publication Number:
  US 20150217124A1
• Time in Patent Office: 1,687 Days
• Field of Search: 600407-480
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/483 by thermal stimulation
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61N 1/403 for thermotherapy, e.g. hyperthermia
• CPC Class Codes: A61N 5/025 Warming the body, e.g. hyperthermia treatment

Abstract

The present invention relates to a radiofrequency (RF) hyperthermia device for personalized treatment and diagnosis using capacitive coupling and without dipole antenna comprising a radiofrequency source, an amplifier, a sensor and a modulation signal input/generator, wherein the radiofrequency source produces a source signal which is modulated by the modulation signal input/generator using the phase information generated by homeostasis of the target to generate a modulated source signal, the modulated source signal is amplified by the amplifier and directed to a target, and the sensor detects the phase information generated by homeostasis of the target to provide a feedback signal, wherein the feedback signal modulates the source signal to generate a personalized modulated signal. This radiofrequency (RF) hyperthermia device is designed for personalized treatment and diagnosis of a target such as a patient or a malignant or tumorous area within a patient.

Claims

1. A radiofrequency hyperthermia device for personalized treatment, personalized prophylaxis and personalized diagnosis using capacitive coupling comprising:

a radiofrequency source for producing a source signal;

a modulator for modulating the source signal to generate a modulated source signal;

an amplifier for amplifying the modulated source signal to generate an amplified modulated signal that is directed to a target area;

a sensor for detecting a phase information of a signal generated by homeostasis of a target area; and

a modulation signal input/generator for generating a modulation signal using said phase information of a measured homeostatic signal,

wherein the measured homeostatic signal is ECG, EEG, EMG, signal of the membrane ion-channels, or a signal generated starting from the morphology of a tissue of the target area.

2. The radiofrequency hyperthermia device according to claim 1, wherein sensor (3) is configured to compare the phase information obtained at time T_n+1 with a previously obtained phase information at time T_n to provide a feedback signal, and wherein n>

0.

3. The radiofrequency hyperthermia device of claim 2, further comprising a multiplicator for fitting the modulation signal to the feedback signal.

4. The radiofrequency hyperthermia device of claim 2, further comprising a feedback amplifier for amplifying the feedback signal.

5. The radiofrequency hyperthermia device of claim 4, wherein the sensor is situated between the target area and the feedback amplifier.

6. The radiofrequency hyperthermia device of claim 1, wherein the modulation signal input/generator comprises a multiplicator and/or a feedback amplifier.

7. The radiofrequency hyperthermia device of claim 1, wherein the sensor is situated between the amplifier and the target area.

8. The radiofrequency device of claim 1, wherein the radiofrequency hyperthermia device uses capacitive coupling in a condenser arrangement wherein the target area is a dielectric material.

9. The radiofrequency device of claim 1, wherein the modulator is configured to modulate an amplitude and a frequency spectrum of the source signal on the basis of the phase information of the measured homeostatic signal and the phase information generated by homeostasis of the target area.

10. The radiofrequency device of claim 2, wherein an algorithm for providing the feedback signal is stored in the sensor, wherein the algorithm is

11. A method for personalized treatment, after-treatment, prophylaxis, prevention of relapse or diagnosis of tumours, cancer, metastases, carcinomas, pain, migraine, or diseases of the central nervous system comprising exposing a target area to an amplified modulated signal from a radiofrequency hyperthermia device of claim 1.

12. A method for personalized treatment, after-treatment, prophylaxis, prevention of relapse or diagnosis of tumours, cancer, metastases, carcinomas, pain, migraine, or diseases of the central nervous system comprising exposing a target area to an amplified modulated signal from a radiofrequency hyperthermia device,

wherein the amplified modulated signal is obtained from a source signal generated by a radiofrequency source, modulated by a modulation signal and amplified, wherein the modulation signal is generated from a feedback signal by modulating the feedback signal using the phase information of a measured homeostatic signal from the target area in a way that the phase information of a signal generated by homeostasis of the target area is detected at time T_n+1 and compared with a previously obtained phase information at time T_n,

wherein the measured homeostatic signal is ECG, EEG, EMG, signal of the membrane ion-channels, or a signal generated starting from the morphology of a tissue of the target area.