Dynamic energy control of a charged particle imaging/treatment apparatus and method of use thereof

• US 9,937,362 B2
• Filed: 10/25/2016
• Issued: 04/10/2018
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: ProTom International Holding Corporation
• Original Assignee: Lee W. Davis, Mark R. Amato, Scott Penfold
• Inventors: Lee, W. Davis, Amato, Mark R., Penfold, Scott
• Primary Examiner(s): IPPOLITO, NICOLE MARIE
• Application Number:
  US15/334,122
• Publication Number:
  US 20170043187A1
• Time in Patent Office: 532 Days
• Field of Search: 250396 R, 250397, 2504921, 2504923
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/4085 Cone-beams
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 6/4266 characterised by using a plurality of detector units A61B6/4014 takes precedence
• CPC Class Codes: A61B 6/4435 the source unit and the detector unit being coupled by a rigid structure
• CPC Class Codes: A61B 6/5205 involving processing of raw data to produce diagnostic data
• CPC Class Codes: A61N 2005/1054 using a portal imaging system
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 2005/1095 Elements inserted into the radiation path within the system, e.g. filters or wedges
• CPC Class Codes: A61N 2005/1097 Means for immobilizing the patient
• CPC Class Codes: A61N 5/1037 taking into account the movement of the target, e.g. 4D-image based planning
• CPC Class Codes: A61N 5/1039 using functional images, e.g. PET or MRI
• CPC Class Codes: A61N 5/1044 with multiple repetitions of the scanning pattern
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1069 Target adjustment, e.g. moving the patient support
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1077 Beam delivery systems
• CPC Class Codes: A61N 5/1082 having multiple beam rotation axes
• CPC Class Codes: G21K 1/08 Deviation, concentration or focusing of the beam by electric or magnetic means electron-optical arrangements in electric discharge tubes H01J29/46; details, e.g. electric or magnetic deviating means for direct voltage accelerators or in accelerators using single pulses H05H5/02; arrangements for injecting particles into orbits H05H7/08; arrangements for ejecting particles from orbits H05H7/10
• CPC Class Codes: G21K 5/04 with beam-forming means

Abstract

The invention comprises a beam adjustment method and apparatus used to perform energy adjustments on circulating charged particles in a synchrotron previously accelerated to a starting energy with a traditional accelerator of the synchrotron. The beam adjustment system uses a radio-frequency modulated potential difference applied along a longitudinal path of the circulating charged particles to accelerate or decelerate the circulating charged particles. Optionally, the beam adjustment system phase shifts the applied radio-frequency field to accelerate or decelerate the circulating charged particles while tightening spatial distribution of a grouped bunch of the circulating charged particles. Optionally, the beam adjustment system simultaneously radially focuses the circulating charged particles using two or more gaps with focusing and/or defocusing edges. The beam adjustment system facilitates treating multiple layers or depths of the tumor without hysteresis and/or between the repeating slow steps of reloading the synchrotron.

Claims

1. A method for treating a tumor of a patient with positively charged particles, comprising the steps of:

loading a synchrotron of a charged particle cancer therapy system with the positively charged particles using a loading system;

using an accelerator of said synchrotron to accelerate the positively charged particles in a circulation beam path of said synchrotron;

removing a first set of the positively charged particles, from said synchrotron, at a first energy using a beam extraction system;

treating the tumor using the first set of positively charged particles;

providing a beam energy adjustment system, comprising;

a first gap axially crossing said circulation beam path; and

a first radio-frequency controller;

applying a potential difference across the first gap, using said first radio-frequency controller, at an applied radio-frequency using said beam energy adjustment system;

timing the applied radio-frequency and the potential difference to alter a remaining grouped bunch of the positively charged particles in said circulation beam path from the first energy to a second energy;

subsequent to said step of removing, extracting a portion of the remaining grouped bunch of the positively charged particles, from said synchrotron, at the second energy prior to reloading said synchrotron using said loading system; and

treating the tumor using the portion of the remaining grouped bunch of the positively charged particles.

2. The method of claim 1, said step of applying the potential difference further comprising the step of:

using an increasing potential, relative to movement of the positively charge particles across the first gap, to decelerate the remaining bunch of the positively charged particles in said circulation beam path.

3. The method of claim 1, said step of applying the potential difference further comprising the step of:

accelerating the remaining bunch of positively charged particles across the first gap using a first potential at an entrance side of the first gap and a relatively lower second potential at an exit side of the first gap.

4. The method of claim 3, said step of timing the radio-frequency further comprising the step of:

phase shifting the radio-frequency to accelerate a trailing edge of the remaining bunch of positively charged particles circulating in said circulation beam path to increase a mean energy of the positively charged particles circulating in said circulation beam path.

5. The method of claim 3, further comprising the step of:

using said accelerator to accelerate the remaining bunch of positively charged particles in said circulation beam path.

6. The method of claim 5, further comprising the step of:

extracting at least two treatment beams from said synchrotron at a corresponding at least two energies without using said accelerator to change energy of the remaining bunch of the positively charged particles in said circulation beam path.

7. The method of claim 6, the at least two energies comprising different Bragg peak depths with a resolution of better than one-half.

8. The method of claim 3, further comprising the step of:

repeating said steps of;

(1) applying the potential difference, (2) timing the potential difference, and (3) extracting to extract n bunches of the positively charged particles at n energies prior to repeating said step of loading, where n is a positive integer of at least three, where the n energies differ from each other by at least one-half of one percent.

9. The method of claim 8, said step of treating, as controlled by said step of applying a potential difference, further comprising the step of:

scanning a treatment beam along a depth of penetration axis into the tumor using the n bunches of the positively charged particles at the n energies.

10. The method of claim 9, said step of scanning further comprising the step of:

overlapping treatment voxels, of less than two cubic millimeters, of adjacent bunches of the n bunches.

11. The method of claim 8, further comprising the step of:

applying a radio-frequency controlled potential drop across a second gap axially crossing said circulation beam path.

12. The method of claim 11, further comprising the steps of:

focusing the remaining bunch of the positively charged particles while crossing the first gap using, the first gap comprising a convex exit surface relative to motion of the positively charged particles; and

defocusing the remaining bunch of the positively charged particles while crossing the second gap, the second gap comprising a concave entrance surface relative to motion of the positively charged particles.

13. The method of claim 12, further comprising the steps of:

imaging a position of a treatment beam from said accelerator relative to the tumor; and

said step of imaging outputting a signal used to dynamically control said step of applying a potential difference across the first gap to correct an energy axis of the treatment beam to a targeted voxel of the tumor.

14. The method of claim 3, said step of loading said accelerator further comprising the step of:

using a gating electrode between an ion source and an extraction electrode to pass the positively charged particles from said ion source to said accelerator.

15. An apparatus for treatment of a tumor of a patient with positively charged particles, comprising:

a charged particle cancer therapy system, comprising;

an accelerator comprising a circulation beam path;

a loading system configured to load said accelerator with the positively charged particles, said accelerator configured to accelerate the positively charge particles;

a beam energy adjustment system, comprising;

a first gap axially crossing the circulation beam path; and

a first radio-frequency controller configured to repeatedly apply at least one potential difference at at least one radio-frequency, the at least one potential difference and the at least one radio-frequency timed to alter a remaining grouped bunch of the positively charged particles from the first energy to a second energy; and

a beam extraction system configured to;

(1) remove from said accelerator a first set of the positively charged particles at the first energy for treatment of the tumor and (2) prior to reloading said accelerator using said loading system, subsequently extract from said accelerator a portion of the remaining grouped bunch of the positively charged particles at the second energy for treatment of the tumor.

16. The apparatus of claim 15, said beam energy adjustment system further comprising:

a second gap axially crossing said circulation beam path; and

a second radio-frequency controller electrically coupled to said second gap.

17. The apparatus of claim 16, said beam energy adjustment system further comprising:

a third gap axially crossing said circulation beam path;

a third radio-frequency controller electrically coupled to sides of said third gap;

at least one entrance surface of any of said first gap, said second gap, and said third gap comprising a concave surface relative to movement of the positively charged particles; and

at least one exit surface of any of said first gap, said second gap, and said third gap comprising a convex surface relative to movement of the positively charged particles.