Modified leptin polypeptides and their uses
First Claim
Patent Images
1. A leptin polypeptide comprising one or more non-naturally encoded amino acids substituted at positions selected from:
- 46, 66, 67, 100, 105, 108, 111 of SEQ ID NO;
4 or the corresponding amino acid encoded by SEQ ID NO;
3 or positions 45, 65, 66, 99, 104, 107, 110 of SEQ ID NO;
2, wherein the non-naturally encoded amino acid in the leptin polypeptide is linked to a water soluble polymer;
wherein the non-naturally encoded amino acid to which the water soluble polymer is linked has the structure;
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Abstract
Modified human leptin polypeptides and uses thereof are provided.
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Citations
9 Claims
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1. A leptin polypeptide comprising one or more non-naturally encoded amino acids substituted at positions selected from:
- 46, 66, 67, 100, 105, 108, 111 of SEQ ID NO;
4 or the corresponding amino acid encoded by SEQ ID NO;
3 or positions 45, 65, 66, 99, 104, 107, 110 of SEQ ID NO;
2, wherein the non-naturally encoded amino acid in the leptin polypeptide is linked to a water soluble polymer;
wherein the non-naturally encoded amino acid to which the water soluble polymer is linked has the structure;
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- 46, 66, 67, 100, 105, 108, 111 of SEQ ID NO;
Specification