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Compositions, methods and uses for alpha-1 antitrypsin fusion molecules

  • US 9,938,353 B2
  • Filed: 06/22/2012
  • Issued: 04/10/2018
  • Est. Priority Date: 06/24/2011
  • Status: Active Grant
First Claim
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1. A nucleic acid construct comprising:

  • a polynucleotide encoding an alpha-1 antitrypsin (AAT) polypeptide fragment wherein the AAT polypeptide fragment consists of the polypeptide sequence represented by SEQ ID NO;

    34;

    a polynucleotide encoding a linker; and

    a polynucleotide encoding an immunoglobulin Fc polypeptide of IgG2, IgG3, IgG4, or IgD.

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