Manifold driver

• US 9,939,075 B2
• Filed: 04/11/2014
• Issued: 04/10/2018
• Est. Priority Date: 04/12/2013
• Status: Active Grant

• Current Assignee: Biocartis NV (Biocartis Group NV)
• Original Assignee: Biocartis NV (Biocartis Group NV)
• Inventors: Kroon, Gerard, De Gier, Ronald
• Primary Examiner(s): Sanchez-Medina, Reinaldo
• Application Number:
  US14/783,582
• Publication Number:
  US 20160069464A1
• Time in Patent Office: 1,460 Days
• Field of Search: 13731517, 13731527, 13731521, 13731535, 13731536, 13731541, 137343, 13762546, 13762547, 137637, 1376371, 1376372, 1376373, 1376374
• CPC Class Codes: B01L 2200/025 Align devices or objects to ensure defined positions relative to each other
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2200/04 Exchange or ejection of cartridges, containers or reservoirs
• CPC Class Codes: B01L 2300/049 Valves integrated in closure
• CPC Class Codes: B01L 2300/0809 rectangular shaped
• CPC Class Codes: B01L 2300/0832 cylindrical, tube shaped
• CPC Class Codes: B01L 2300/087 Multiple sequential chambers
• CPC Class Codes: B01L 2400/0478 pistons
• CPC Class Codes: B01L 2400/0644 rotary valves
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: F16K 27/04 of sliding valves
• CPC Class Codes: F16K 3/0218 with only one sealing face
• CPC Class Codes: F16K 3/30 Details
• CPC Class Codes: G01N 35/0099 comprising robots or similar manipulators robots per se B25J
• CPC Class Codes: G01N 35/1009 Characterised by arrangements for controlling the aspiration or dispense of liquids

Abstract

A fluid control and processing system comprising a cartridge and an instrument for operating the cartridge. The cartridge comprises a cylinder body comprising a cylinder and a fluid port. It further comprises dispensing ports to drive a fluid flow, each dispensing port being positioned to be connectable, when the instrument is operating the cartridge, with at least a fluid port by rotation of the cylinder body. The instrument comprises a piston driver for driving the piston. The system further comprises: reversible fastening means for fastening the piston when the piston driver is rotated with respect to the piston, so that the movement of the piston is controlled by the piston driver; and rotating means comprising a cylinder driver constitutive of the instrument for rotating the cylinder body around the axis A.

Claims

1. A fluid control and processing system comprising:

a cartridge;

a cylinder body being received in the cartridge, said cylinder body comprised of a cylinder and a fluid port in fluid communication with said cylinder;

a piston movable in the cylinder to modulate a fluid volume inside said cylinder;

an instrument for operating the cartridge, said instrument including;

a piston driver for driving the piston, and

rotating means including a cylinder driver for rotating the cylinder body around an axis A which extends along the piston driver;

dispensing ports to drive at least a fluid flow, each dispensing port being positioned to be connectable, when the instrument is operating the cartridge, with the fluid port by rotation of the cylinder body; and

reversible fastening means for fastening the piston to the piston driver so that movement of the piston is controlled by the piston driver, wherein the reversible fastening means fastens the piston to the piston driver when the instrument rotates the piston driver with respect to the piston in a first direction around the axis A, and unfastens the piston from the piston driver when the instrument rotates the piston driver with respect to the piston in a second direction opposite to the first direction.

2. The fluid control and processing system according to claim 1, wherein the fastening means comprise at least two parts, a first part and a second part, the piston being attached to said first part and the piston driver comprising said second part.

3. The fluid control and processing system according to claim 1 wherein, when the fastening means fasten the piston with the piston driver, a translation of the piston driver in a direction along the axis A causes a translation of the piston in the same direction.

4. The fluid and control and processing system according to claim 1, wherein the cylinder driver forms a revolute joint with the cylinder body.

5. The fluid control and processing system according to claim 1, wherein the fastening means comprise a bayonet mount.

6. The fluid control and processing system according to claim 1, wherein the system further comprises:

interlocking means for interlocking the piston driver and the rotating means, so that the rotation of the cylinder body is controllable by the piston driver, when the piston driver and the piston are fastened by the fastening means.

7. The fluid control and processing system according to claim 6, wherein the interlocking means prevents the rotation of piston driver with respect to the piston in the second direction.

8. The fluid control and processing system according to claim 6, wherein the system further comprises a prismatic connection between the interlocking means and the piston driver and a clamping joint, between the rotating means and the interlocking means.

9. The fluid control and processing system according to claim 6, wherein the interlocking means further comprises a guide bush, wherein a rotation of the guide bush causes simultaneous rotation of the piston driver and of the cylinder driver once the piston driver is fastened to the piston and when the cylinder driver is coupled with the cylinder body.

10. A cartridge comprising:

a cylinder body comprised of a cylinder and a fluid port in fluid communication with the cylinder; and

a piston movable in the cylinder to modulate a fluid volume inside the cylinder,

wherein said cartridge is used in a fluid control and processing system comprising;

an instrument for operating the cartridge, said instrument comprised of;

a piston driver for driving the piston, and

rotating means including a cylinder driver for rotating the cylinder body around an axis A which extends along the piston driver;

dispensing ports to drive at least a fluid flow, each dispensing port being positioned to be connectable, when the instrument is operating the cartridge, with the fluid port by rotation of the cylinder body; and

reversible fastening means for fastening the piston to the piston driver so that movement of the piston is controlled by the piston driver, wherein the reversible fastening means fastens the piston to the piston driver when the instrument rotates the piston driver with respect to the piston in a first direction around the axis A and unfastens the piston from the piston driver when the instrument rotates the piston driver with respect to the piston in a second direction opposite to the first direction.

11. An instrument comprising:

a piston driver defining an axis A which extends along the piston driver, and a cylinder driver;

wherein said instrument is used in a fluid control and processing system including;

a cartridge operated by the instrument;

a cylinder body being received in the cartridge and arranged to be rotated by the cylinder driver around the axis A, said cylinder body comprising a cylinder and a fluid port in fluid communication with said cylinder;

a piston movable in the cylinder to modulate a fluid volume inside said cylinder, said piston driven by the piston driver;

dispensing ports to drive at least a fluid flow, each dispensing port being positioned to be connectable, when the instrument is operating the cartridge, with the fluid port by rotation of the cylinder body;

reversible fastening means for fastening the piston to the piston driver so that movement of the piston is controlled by the piston driver, wherein the reversible fastening means fastens the piston to the piston driver when the instrument rotates the piston driver with respect to the piston in a first direction around the axis A and unfastens the piston from the piston driver when the instrument rotates the piston driver with respect to the piston in a second direction opposite to the first direction.