Radioimaging using low dose isotope

• US 9,943,274 B2
• Filed: 12/09/2013
• Issued: 04/17/2018
• Est. Priority Date: 11/09/2004
• Status: Active Grant

• Current Assignee: Spectrum Dynamics Medical Ltd
• Original Assignee: Spectrum Dynamics Medical Ltd
• Inventors: Rousso, Benny, Ben-Haim, Shlomo, Ravhon, Ran, Zilberstein, Yoel, Dichterman, Eli, Ben-Haim, Simona, Roth, Nathaniel
• Primary Examiner(s): Bryant, Casey
• Application Number:
  US14/100,082
• Publication Number:
  US 20140163368A1
• Time in Patent Office: 1,590 Days
• CPC Class Codes: A61B 5/06 Devices, other than using radiation, for detecting or locating foreign bodies for removing same A61B17/50 ; determining position of probes within or on the body of the patient
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61B 5/418 lymph vessels, ducts or nodes
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: A61B 6/0414 with compression means
• CPC Class Codes: A61B 6/425 using detectors specially adapted to be used in the interior of the body
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 6/4266 characterised by using a plurality of detector units A61B6/4014 takes precedence
• CPC Class Codes: A61B 6/4275 using a detector unit almost surrounding the patient, e.g. more than 180°
• CPC Class Codes: A61B 6/4291 the detector being combined with a grid or grating
• CPC Class Codes: A61B 6/44 Constructional features of apparatus for radiation diagnosis
• CPC Class Codes: A61B 6/488 involving pre-scan acquisition
• CPC Class Codes: A61B 6/501 for diagnosis of the head, e.g. neuroimaging or craniography
• CPC Class Codes: A61B 6/502 for diagnosis of breast, i.e. mammography
• CPC Class Codes: A61B 6/507 for determination of haemodynamic parameters, e.g. perfusion CT
• CPC Class Codes: A61B 6/541 involving acquisition triggered by a physiological signal
• CPC Class Codes: A61B 6/547 involving tracking of position of the device or parts of the device
• CPC Class Codes: A61B 6/548 Remote control of the apparatus or devices
• CPC Class Codes: A61B 6/583 : using calibration phantoms
• CPC Class Codes: A61B 8/0808 : for diagnosis of the brain
• CPC Class Codes: A61B 8/0825 : for diagnosis of the breast, e.g. mammography
• CPC Class Codes: A61B 8/12 : in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/4416 : related to combined acquisition of different diagnostic modalities, e.g. combination of ultrasound and X-ray acquisitions
• CPC Class Codes: A61B 8/543 : involving acquisition triggered by a physiological signal
• CPC Class Codes: A61K 51/00 : Preparations containing radioactive substances for use in therapy or testing in vivo
• CPC Class Codes: A61K 51/0478 : complexes from non-cyclic ligands, e.g. EDTA, MAG3
• CPC Class Codes: A61K 51/1048 : the tumor cell determinant being a carcino embryonic antigen
• CPC Class Codes: G01R 33/481 : MR combined with positron emission tomography [PET] or single photon emission computed tomography [SPECT]
• CPC Class Codes: G01T 1/1615 : using both transmission and emission sources simultaneously SPECT imaging G01T1/1642; PET imaging G01T1/2985; detecting prohibited goods, e.g. weapons, explosives, hazardous substances, contraband or smuggled objects G01V5/20
• CPC Class Codes: G01T 1/1642 : using a scintillation crystal and position sensing photodetector arrays, e.g. ANGER cameras
• CPC Class Codes: G01T 1/2985 : In depth localisation, e.g. using positron emitters; Tomographic imaging (longitudinal and transverse section imaging; apparatus for radiation diagnosis sequentially in different planes, steroscopic radiation diagnosis); using external radiation sources A61B6/02

Abstract

Radioimaging methods, devices and radiopharmaceuticals therefor.

Claims

1. Apparatus for radioactive imaging of a volume, comprising:

a conformable radiation camera configurable to a body contour of a patient adjacent a target area of interest;

the camera including a plurality of detector modules;

an adjustable support on which the detector modules are moveably mounted wherein position and orientation of said detector modules are moveable relative to each other including translational motion along at least a first axis and oscillatory movement of each said detector module about a respective second axis which intersects said first axis; and

an actuator arrangement for configuring the detector modules to conform the camera to the body contour;

wherein said detector modules are configured to sweep a plane within the volume, said sweeping a plane performed by adjusting a configuration of said detector modules, wherein said adjusting includes said oscillatory movement of at least one said moveable detector modules about said respective second axis, wherein said oscillatory movement is performable during said imaging to provide different views for imaging.

2. Apparatus according to claim 1, wherein the support comprises a frame coupled to a patient support.

3. Apparatus according to claim 1, wherein the detector modules are comprised of individual detector units and the actuator arrangement is operable to move the individual detector units relative to each other.

4. Apparatus according to claim 1, wherein the detector modules are comprised of blocks of multiple individual detector units and the actuator arrangement is operable to move the detector blocks relative to each other.

5. Apparatus according to claim 1, wherein the detector modules are comprised of individual detector units, or one or more blocks of multiple individual detector units and each detector module includes a motion provider operable to move the detector modules with two or more degrees of motion.

6. Apparatus according to claim 5, wherein the detector module is independently moveable along at least one rotational axis.

7. Apparatus according to claim 5, further including a position tracking device for each detector module.

8. Apparatus according to claim 7, wherein the position tracking device is one of magnetic or electromagnetic, or optical using one or more cameras, or ultrasonic, or accelerometer-based, or potentiometer-based, or radio-frequency-based.

9. Apparatus according to claim 7, including an encoder operative as the position tracking device for each independently moveable detector module.

10. Apparatus according to claim 1, wherein the support for the detector modules is a flexible structure.

11. Apparatus according to claim 1, wherein the support for the detector modules is a flexible sheet of material or links connecting adjacent detector units.

12. Apparatus according to claim 1, wherein the detector support is configured so that the detector modules are positionable within 5 centimeters of the body.

13. Apparatus according to claim 1, wherein the detector modules are configurable to limit wasteful viewing to less than 50% of the viewing time of each detector module.

14. Apparatus according to claim 1, wherein the detector modules are configured so that all detector modules are positionable to view the body structure.

15. Apparatus according to claim 1, further including a collimator arrangement for the detector modules that provides a collection solid angle of at least 0.0005 steradians.

16. Apparatus according to claim 1, further including a collimator arrangement for the detector modules that provides a collection solid angle enabling a view of substantially a whole organ.

17. Apparatus according to claim 1, wherein the size of the individual detector units along a rotational axis of the apparatus, is less than 10 cm.

18. Apparatus according to claim 1, wherein the detector modules are comprised of blocks of individual detector units positioned along one or more lines in the camera, and each block includes a collimator, wherein the collimator for at least one of the blocks is configured differently from the collimator of at least one other detector module at a different position along the one or more lines.

19. Apparatus according to claim 18, wherein detector blocks at the edges of the detector modules have wide-angle collimators and detector blocks in the central portion of the detector modules have narrower-angle collimators.

20. Apparatus according to claim 1, wherein the detector module is comprised of blocks of detector units arranged in at least one row with hinges connecting adjacent detector blocks such that the angles between the blocks may be adjusted.

21. Apparatus according to claim 20, including at least two opposed rows of detector blocks positionable to surround a patient support and a drive mechanism for providing relative longitudinal movement between the patient support and the opposed detector rows allowing whole body imaging.

22. Apparatus according to claim 1, including an encoder operative as a position tracking device for each independently moveable detector unit or block of multiple detector units.

23. A method of radioactive imaging of a volume, comprising:

providing a conformable radiation camera that includes a plurality of detector modules mounted on an adjustable support, wherein position and orientation of the detector modules are moveable relative to each other including translational motion along at least a first axis and oscillatory movement of each said detector module about a respective second axis which intersects said first axis;

identifying a body contour adjacent a target area of interest;

linearly translating at least one of said plurality of detector modules to conform the camera to the contour; and

sweeping a plane within the volume, said sweeping performed by adjusting a configuration of the detector modules, wherein said adjusting include said oscillatory movement of at least one of said moveable detector modules about said respective second axis, wherein said oscillatory movement is performed during said imaging to provide different views for imaging.

24. A method according to claim 23, further including using a motion provider to adjust the configuration of one or more of the detector modules to conform the camera to the body contour.

25. A method according to claim 24, further including using a position tracking device to determine the position of each independently moveable detector module.

26. A method according to claim 25 wherein the position tracking device used is one of magnetic or electromagnetic, or optical using one or more cameras.

27. A method according to claim 25, wherein the position tracking device used is ultrasonic, or accelerometer-based, or potentiometer-based, or radio-frequency-based.

28. A method according to claim 25 wherein the position tracking device used is an encoder.

29. A method according to claim 23, wherein the detector modules are comprised of individual detector units or multiple detector units arranged in blocks.

30. A method according to claim 29, wherein adjusting is performed by moving one or more of the individual detector units or one or more of the blocks of detector units comprised in the detector modules linearly and/or angularly.

31. A method according to claim 30, wherein at least some of the detector units or blocks of detector units are moveable independently relative to each other.

32. A method according to claim 23, comprising adjusting a configuration of the detector modules in accordance with a predetermined schedule to provide different views that are used for imaging.

33. A method according to claim 23, wherein said adjusting includes adjusting the camera to provide different views of different body areas to take account of the physiology of specific target areas as compared to nearby non-target areas.

34. A method according to claim 23, wherein the camera is controlled to perform a cursory scan and further including using the results of the cursory scan to alter a schedule of views for performing a full scan.

35. A method according to claim 34, wherein a particular view in an altered schedule of views provides a longer examination of parts of the target area.

36. A method according to claim 23, wherein the camera provided is configured to meet one or more of the following criteria:

i. the detector modules are positionable within 5 centimeters of the body;

ii. wasteful viewing for less than 50% of the viewing time of each detecting module;

iii. substantially no detector module is positionable so as not to view the body structure at all;

iv. a detector module size along a rotational axis of the apparatus is less than 10 cm;

v. independent motion control for each detector module is provided along at least one rotational axis.

37. A method according to claim 23, wherein the camera provided is configured to meet one or both of the following criteria:

i. collimators provide a solid collection angle of at least 0.0005 steradians, for the detector modules;

ii. collimators provide collection solid angles for the detector modules enabling a view of substantially a whole organ, or a selected portion of the organ.

38. The method of claim 23, wherein said oscillatory movement comprises sweeping a detector unit or block of detector units a plurality of times through a plane.

39. The method of claim 38, wherein said oscillatory movement is of more than one detector unit or block of detector units.

40. The method of claim 23, wherein said adjustable support includes a plurality of tracks, wherein one or more detector module is moveable along a track.

41. The method of claim 40, wherein said detector modules each comprise multiple detector units.

42. The method of claim 23, wherein said second axis is perpendicular to said first axis.

43. The method of claim 23, wherein said oscillatory movement of said at least one of said moveable detector modules is in a sweep angle about a detector module radius, and wherein said oscillatory movement is continuous along said sweep angle.

44. The method of claim 23, wherein said oscillatory movement of said at least one of said moveable detector modules is in a sweep angle about a detector module radius, and wherein said oscillatory movement is in stepped motions along said sweep angle.

45. The method of claim 23, wherein said conformable radiation camera further includes a motor configured for changing said position and orientation of the detector modules relative to each other, said changing said position and orientation including said translational motion and said oscillatory movement about the support;

and a controller configured for controlling said translational motion and said oscillatory movement;

wherein said controller controls said motor to linearly translate said at least one of said plurality of detector modules to conform the camera to the contour; and

wherein said controller controls said motor to actuate oscillatory movement of at least one of said moveable detector modules about the support.

46. The method according to claim 23, wherein said oscillatory movement of each detector module is mechanically independent of oscillatory movement of any other detector module.

47. The method according to claim 23, wherein said oscillatory movement of a pair of detector modules relative to each other is synchronized.

48. The method according to claim 23, wherein said oscillatory movement of a pair of detector modules relative to each other is synchronized in an antipodal manner.

49. The method according to claim 23, further including, after said sweeping:

moving said plurality of detectors around the first axis; and

sweeping a second plane with the volume, said sweeping a second plane performed by oscillatory movement of at least one of said detector modules about said second axis, where said sweeping a second plane provides additional different views for imaging.

50. The method according to claim 23, wherein an external surface of said camera to which said detector modules are attached remains stationary during said adjusting by oscillatory movement.

51. The method of claim 23 further including, after said adjusting, providing a scoring function for sets of at least one view, said scoring function rating information obtained from the different views provided.

52. The method of claim 51 further including, after said scoring, selecting a set of views based on the score of the set of views.

53. The method of claim 52, wherein said selecting a set of views is based on information theoretic measures of the sets of views, said measures including at least one of:

uniformity of detected radioactive emission in a set of views;

resolution between pairs of voxels in a set of views;

repeatability of measurements; and

a weighted combination thereof.

54. The method of claim 23, wherein said providing a conformable radiation camera includes selecting a camera configuration from a plurality of camera configurations, based on scores of their respective collections of views.