Modular tissue scaffolds
First Claim
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1. A biocompatible system for filling a tissue gap comprising:
- a first module that is biocompatible and degradable and a second module that is biocompatible and degradable;
wherein one of each module has an irregular disk shape having two flat sides and each module comprises a dovetail connector on each flat side, wherein the dovetail connectors from one of the first or second module is designed to couple with one of the dovetail connectors from the other of the first or second module and wherein the circumference of the irregular disk correspond to a shape of the gap being filled by the tissue scaffold;
a biocompatible and degradable tissue scaffold rack comprising a trough shaped portion having two side regions, a bottom region, a proximal end and a distal end,wherein the tissue scaffold rack comprises a first coupling portion having a first shape and the first module comprises a second coupling portion having a second shape that corresponds to the first shape, wherein the second coupling portion of the first module is designed to engage with the first coupling portion of the tissue scaffold rack;
wherein the modules fit into the trough shaped region by contacting the bottom region and substantially spanning the two side regions; and
,each of the first and second module and the rack have a porous microstructure, are synthesized from polycaprolactone and are substantially coated with calcium-deficient carbonate-containing hydroxyapatite.
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Abstract
Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds.
60 Citations
13 Claims
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1. A biocompatible system for filling a tissue gap comprising:
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a first module that is biocompatible and degradable and a second module that is biocompatible and degradable; wherein one of each module has an irregular disk shape having two flat sides and each module comprises a dovetail connector on each flat side, wherein the dovetail connectors from one of the first or second module is designed to couple with one of the dovetail connectors from the other of the first or second module and wherein the circumference of the irregular disk correspond to a shape of the gap being filled by the tissue scaffold; a biocompatible and degradable tissue scaffold rack comprising a trough shaped portion having two side regions, a bottom region, a proximal end and a distal end, wherein the tissue scaffold rack comprises a first coupling portion having a first shape and the first module comprises a second coupling portion having a second shape that corresponds to the first shape, wherein the second coupling portion of the first module is designed to engage with the first coupling portion of the tissue scaffold rack; wherein the modules fit into the trough shaped region by contacting the bottom region and substantially spanning the two side regions; and
,each of the first and second module and the rack have a porous microstructure, are synthesized from polycaprolactone and are substantially coated with calcium-deficient carbonate-containing hydroxyapatite. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification