Compositions and methods for increasing energy metabolism
First Claim
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1. A composition comprising:
- (a) a synergistically effective amount of a phosphodiesterase 5 (PDE
5) inhibitor; and
(b) at least 500 mg of leucine and/or at least 200 mg of a leucine metabolite, wherein the PDE 5 inhibitor comprises sildenafil.
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Abstract
Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions comprise a combination of a PDE 5 inhibitor, such as sildenafil or icariin, and resveratrol, and a branched amino acid such as leucine, or its metabolite.
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Citations
21 Claims
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1. A composition comprising:
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(a) a synergistically effective amount of a phosphodiesterase 5 (PDE
5) inhibitor; and(b) at least 500 mg of leucine and/or at least 200 mg of a leucine metabolite, wherein the PDE 5 inhibitor comprises sildenafil. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification