Minimizing biological lipid deposits on contact lenses

• US 9,943,622 B2
• Filed: 09/24/2013
• Issued: 04/17/2018
• Est. Priority Date: 10/08/2012
• Status: Active Grant

• Current Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Inventors: Liu, X. Michael, Chinn, Joseph A., Grobe, III, George L., Maziarz, E. Peter
• Primary Examiner(s): TRAN, SUSAN T
• Application Number:
  US14/427,928
• Publication Number:
  US 20160022860A1
• Time in Patent Office: 1,666 Days
• Field of Search: None
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61L 12/14 Organic compounds not covered by groups A61L12/10 or A61L12/12
• CPC Class Codes: A61L 12/143 Quaternary ammonium compounds
• CPC Class Codes: A61L 12/145 Polymeric quaternary ammonium compounds
• CPC Class Codes: C11D 1/62 Quaternary ammonium compounds
• CPC Class Codes: C11D 3/0078 Compositions for cleaning contact lenses, spectacles or lenses
• CPC Class Codes: C11D 3/48 Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Abstract

Method for minimizing the sorption of tear lipids on frequent replacement, or extended-wear, contact lenses, the method comprising (a) contacting the contact lens selected from the group consisting of senofilcon A, lotrafilcon A, lotrafilcon B, and comfilcon A B with a lens care solution for a period of at least three hours to minimize the accumulation of tear lipids on the contact lens. The lens care solution comprises 0.5 ppm to 10 ppm α-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl) ammonium chloride; citrate, citric acid or a mixture thereof; and 0.005 wt. % to 0.05 wt. % hyaluronic acid. The method also includes (b) inserting the soaked contact lens into one'"'"'s eye, and (c) repeating steps (a) and (b).

Claims

1. A method for minimizing the sorption of tear lipids on frequent replacement, or extended-wear, contact lenses, the method comprising:

(a) contacting the contact lens selected from the group consisting of senofilcon A, lotrafilcon A, lotrafilcon B, and comfilcon A with a lens care solution for a period of at least three hours to minimize the accumulation of tear lipids on the contact lens, the lens care solution comprising;

0.5 ppm to 10 ppm α

-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω

-tris(2-hydroxyethyl) ammonium chloride;

citrate, citric acid or a mixture thereof; and

a lipid sorption inhibitor selected from the group consisting of;

hyaluronic acid at a concentration of 0.005 wt. % to 0.05 wt. %; and

an amphoteric surfactant of general formula I at a concentration of 0.01 wt. % to 0.8 wt. %

2. The method of claim 1, wherein the composition comprises hyaluronic acid at a concentration of 0.005 wt. % to 0.05 wt. %.

3. The method of claim 1, wherein the composition comprises the amphoteric surfactant of general formula I at a concentration of 0.01 wt. % to 0.8 wt. %.

4. The method of claim 1, wherein the lens care solution further comprises 0.5 ppm to 1.3 ppm of poly(hexamethylene biguanide), or 2 ppm to 5 ppm of alexidine.

5. The method of claim 2, wherein the lens care solution further comprises 0.01 wt. % to 0.8 wt. % of the amphoteric surfactant of general formula I.

6. The method of claim 1, wherein the lens care solution further comprises propylene glycol or myristamidopropyl dimethylamine.

7. The method of claim 1, wherein the repeating of steps (a) and (b) occurs at least once every seven days.