Ultrasonic catheter power control

• US 9,943,675 B1
• Filed: 09/04/2014
• Issued: 04/17/2018
• Est. Priority Date: 04/01/2002
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: EKOS Corporation (Boston Scientific Corporation)
• Inventors: Keilman, George, Hansmann, Douglas R., Soltani, Azita, Wilson, Richard R.
• Primary Examiner(s): Stigell, Theodore
• Application Number:
  US14/477,673
• Time in Patent Office: 1,321 Days
• CPC Class Codes: A61B 17/320068 using mechanical vibrations, e.g. ultrasonic A61B17/22012 takes precedence; dental tooth drilling devices operated by vibration A61C3/03; removing intra-ocular material using mechanical vibrations A61F9/00745
• CPC Class Codes: A61B 2017/320069 for ablating tissue
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Abstract

A method of treating an occlusion at a treatment site within a patient'"'"'s vasculature comprises providing an ultrasonic catheter. The ultrasonic catheter has a distal region, a proximal region opposite the distal region, a fluid delivery lumen having at least one opening in the distal region, and an ultrasound radiating member positioned within the distal region. The method further comprises positioning the ultrasonic catheter at the treatment site, such that at least a portion of the distal region is within the occlusion. The ultrasonic catheter further comprises passing a therapeutic compound through the fluid delivery lumen such that the therapeutic compound is delivered to the treatment site. The ultrasonic catheter further comprises emitting ultrasonic energy from the ultrasound radiating member. The emitted ultrasonic energy has an amplitude that is periodically varied between a low amplitude and a high amplitude.

Claims

1. A method of treating an occlusion at a treatment site within a patient'"'"'s vasculature comprising:

providing an ultrasonic catheter having a distal region with an outer diameter less than about 5 French, a proximal region opposite the distal region, a fluid delivery lumen having at least one opening in the distal region, and an ultrasound radiating member positioned within the distal region;

positioning the ultrasonic catheter at the treatment site, such that at least a portion of the distal region is within the occlusion;

passing a therapeutic compound through the fluid delivery lumen such that the therapeutic compound is delivered to the treatment site;

emitting ultrasonic energy from the ultrasound radiating member, wherein the emitted ultrasonic energy has;

an amplitude that is periodically varied between a low amplitude and a high amplitude, and

an in situ intensity at an energy radiating surface of between approximately 20 watts in<sup>−

2</sup> and approximately 90 watts in<sup>−

2</sup>.

2. A method comprising:

providing a catheter having an ultrasound radiating member positioned in a catheter distal region, wherein the ultrasound radiating member has a hollow central region;

delivering a therapeutic compound through the catheter to a blood vessel, such that the therapeutic compound passes through the ultrasound radiating member hollow central region; and

passing an electrical driving signal through the catheter to the ultrasound radiating member, such that the ultrasound radiating member periodically delivers pulses of ultrasonic energy having an in situ intensity at an energy radiating surface of between approximately 20 watts in<sup>−

2</sup> and approximately 90 watts in<sup>−

2</sup> to the blood vessel, the pulses of ultrasonic energy having a pulse duration.