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High density DNA array

  • US 9,944,984 B2
  • Filed: 02/06/2017
  • Issued: 04/17/2018
  • Est. Priority Date: 06/15/2005
  • Status: Active Grant
First Claim
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1. A high density DNA array comprisinga patterned surface, said surface comprising a pattern of DNA binding regions separated by a non-DNA binding surface, andmore than 105 different DNAs comprising genomic sequences bound on the array at the DNA binding regions,wherein the DNA binding regions comprise oligonucleotides for binding the DNAs within the DNA binding regions and all of the DNA binding regions of the array comprise the same oligonucleotides, andwherein:

  • the density of the DNA binding regions on the array is more than 100,000 per mm2,more than 50% of the DNA binding regions in the array have multiple copies of one single DNA of said more than 105 different DNAs,the sequence of the single DNA at each DNA binding region is not known, andthe array is not a bead array.

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