Durable antimicrobial composition

• US 9,949,477 B2
• Filed: 12/30/2010
• Issued: 04/24/2018
• Est. Priority Date: 12/30/2010
• Status: Active Grant

• Current Assignee: Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation)
• Original Assignee: Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation)
• Inventors: Cunningham, Corey T., Vongsa, Rebecca Ann, Mundschau, Stacy A., Koenig, David W., Hoffman, Douglas R.
• Primary Examiner(s): Cabral, Robert S
• Application Number:
  US12/982,058
• Publication Number:
  US 20120171155A1
• Time in Patent Office: 2,672 Days
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 37/36 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
• CPC Class Codes: A01N 59/00 Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds

Abstract

The present invention relates to compositions having durable antimicrobial activity. The compositions include a carbonate/bicarbonate salt of a quaternary ammonium cation, an organic acid, hydrogen peroxide and a polymer. The polymer is selected from cationic amine polymer-epichlorohydrin adduct, cationic amine polymer-epichlorohydrin resin, poly(methacrylamidopropyltrimethylammonium) chloride, poly(bis(2-chloroethyl)ether-alt-1,3-bis(dimethylamino)propyl)urea, poly(diallyldimethylammonium) chloride, poly(t-butyl acrylate co-ethyl acrylate co-methacrylic acid), polyethylene oxide, polyquaternium-16, polyquaternium-22, polyquaternium-67 and mixtures thereof.

Claims

1. A composition having durable antimicrobial activity comprising:

a carbonate/bicarbonate salt of a quaternary ammonium cation;

an organic acid;

hydrogen peroxide; and

a polymer selected from cationic amine polymer-epichlorohydrin adduct, cationic amine polymer-epichlorohydrin resin, poly(methacrylamidopropyltrimethylammonium) chloride, poly(bis(2-chloroethyl)ether-alt-1,3-bis(dimethylamino)propyl)urea, poly(diallyldimethylammonium) chloride, polyquaternium-16, polyquaternium-22, and mixtures thereof,

wherein the composition is liquid at room temperature,

wherein the composition comprises from 67% by weight to 98% by weight of a polar carrier solvent, wherein the polar carrier solvent comprises water, and wherein water comprises at least 50% of the composition by weight of the composition, and wherein the composition is stable after storage for three months at 40°

C. to retain antimicrobial activity after twenty-five insults of E. coli as measured by a log 3 reduction in organisms upon the twenty-fifth insult of 10⁶ total organisms.

2. The composition of claim 1 wherein the carbonate/bicarbonate salt of a quaternary ammonium cation is selected from dioctyldimethylammonium carbonate, decyloctyldimethylammonium carbonate, didecyldimethylammonium carbonate, benzalkonium carbonate, benzethonium carbonate, stearalkonium carbonate, cetrimonium carbonate, behentrimonium carbonate, dioctyldimethylammonium bicarbonate, decyloctyldimethylammonium bicarbonate, didecyldimethylammonium bicarbonate, benzalkonium bicarbonate, benzethonium bicarbonate, stearalkonium bicarbonate, cetrimonium bicarbonate, behentrimonium bicarbonate and mixtures thereof.

3. The composition of claim 1 wherein the organic acid is selected from citric, malic, maleic, oxalic, glutaric, succinic, lactic, glycolic, fumaric, acetic, benzoic, propionic, sorbic, tartaric, formic and mixtures thereof.

4. The composition of claim 1 wherein the composition further comprises urea.

5. The composition of claim 1 wherein the composition is effective against Gram positive bacteria, Gram negative bacteria, enveloped viruses, non-enveloped viruses, fungi, fungal spores, mildew and mold.

6. The composition of claim 1 wherein the composition includes from 0.2% by weight to 15.0% by weight of the carbonate/bicarbonate salt of a quaternary ammonium cation.

7. The composition of claim 1 wherein the composition includes from 0.1% by weight to 3.0% by weight of the organic acid.

8. The composition of claim 1 wherein the composition includes from 0.5% by weight to 5.0% by weight of hydrogen peroxide.

9. The composition of claim 1 wherein the composition includes from 0.5% by weight to 10% by weight of polymer.

10. The composition of claim 1 wherein the composition is incorporated into a nonwoven basesheet.

13. The composition of claim 1, wherein the polymer is selected from cationic amine polymer-epichlorohydrin adduct, cationic amine polymer-epichlorohydrin resin, poly(methacrylamidopropyltrimethylammonium) chloride, poly(bis(2-chloroethyl)ether-alt-1,3-bis(dimethylamino)propyl)urea, poly(diallyldimethylammonium) chloride, polyquaternium-22, and mixtures thereof.

11. A nonwoven basesheet including a durable, antibacterial composition comprising from 0.2 to 15.0% by weight of a carbonate/bicarbonate salt of a quaternary ammonium cation;

from 0.1 to 3.0% by weight of an organic acid;

from 0.5 to 5.0% by weight of hydrogen peroxide; and

from 0.5 to 10% by weight of a polymer selected from cationic amine polymer-epichlorohydrin adduct, cationic amine polymer-epichlorohydrin resin, poly(methacrylamidopropyltrimethylammonium) chloride, poly(bis(2-chloroethyl)ether-alt-1,3-bis(dimethylamino)propyl)urea, poly(diallyldimethylammonium) chloride, polyquaternium-16, polyquaternium-22, and mixtures thereof,

wherein the composition is liquid at room temperature,

wherein the composition comprises from 67% by weight to 98% by weight of a polar carrier solvent, wherein the polar carrier solvent comprises water, and wherein water comprises at least 50% of the composition by weight of the composition, and wherein the composition is stable after storage for three months at 40°

C. to retain antimicrobial activity after twenty-five insults of E. coli as measured by a log 3 reduction in organisms upon the twenty-fifth insult of 10⁶ total organisms.

14. The nonwoven basesheet of claim 11, wherein the polymer is selected from cationic amine polymer-epichlorohydrin adduct, cationic amine polymer-epichlorohydrin resin, poly(methacrylamidopropyltrimethylammonium) chloride, poly(bis(2-chloroethyl)ether-alt-1,3-bis(dimethylamino)propyl)urea, poly(diallyldimethylammonium) chloride, polyquaternium-22, and mixtures thereof.

12. A method of providing sustained antimicrobial activity on a surface comprising the steps of:

providing a composition, the composition comprising a carbonate/bicarbonate salt of a quaternary ammonium cation;

an organic acid;

hydrogen peroxide; and

a polymer selected from cationic amine polymer-epichlorohydrin adduct, cationic amine polymer-epichlorohydrin resin, poly(methacrylamidopropyltrimethylammonium) chloride, poly(bis(2-chloroethyl)ether-alt-1,3-bis(dimethylamino)propyl)urea, poly(diallyldimethylammonium) chloride, and mixtures thereof;

applying the composition to the surface in an amount to substantially cover the surface; and

re-applying the composition to the surface after 48 hours,

wherein the composition is liquid at room temperature,

wherein the composition comprises from 67% by weight to 98% by weight of a polar carrier solvent, wherein the polar carrier solvent comprises water, and wherein water comprises at least 50% of the composition by weight of the composition, and wherein the composition is stable after storage for three months at 40°

C. to retain antimicrobial activity after twenty-five insults of E. coli as measured by a log 3 reduction in organisms upon the twenty-fifth insult of 10⁶ total organisms.

15. The method of claim 12, wherein the polymer is selected from cationic amine polymer-epichlorohydrin adduct, cationic amine polymer-epichlorohydrin resin, poly(methacrylamidopropyltrimethylammonium) chloride, poly(bis(2-chloroethyl)ether-alt-1,3-bis(dimethylamino)propyl)urea, poly(diallyldimethylammonium) chloride, polyquaternium-22, and mixtures thereof.