System, method and apparatus with multiple reservoirs for in situ calibration of implantable sensors
First Claim
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1. A subcutaneous sensor system with multiple reservoirs for calibrating solutions comprising:
- a sensor having a sensor output;
a plurality of reservoirs provided with a corresponding plurality of reservoir outlets, wherein there are N reservoirs and N reservoir outlets;
a plurality of pumps provided with a corresponding plurality of pump inlets and a corresponding plurality of pump outlets, wherein the plurality of pump inlets are coupled to the plurality of reservoir outlets, wherein there are N pumps, N pump inlets and N pump outlets, wherein the N pump inlets are coupled to the N reservoir outlets, and wherein a first reservoir of the plurality of reservoirs contains a first calibration solution and a second reservoir of the plurality of reservoirs contains a second calibration solution different from the first calibration solution;
a mixing valve provided with a plurality of mixing valve inlets and a mixing valve outlet, wherein the plurality of mixing valve inlets comprise N mixing valve inlets that are coupled to the N pump outlets and wherein the first calibration solution and the second calibration solution are mixed in the mixing valve to provide a third calibration solution that is intermediate to the first calibration solution and the second calibration solution; and
a controller having an input coupled to the sensor output and a plurality of control outputs coupled to the plurality of pumps and the mixing valve, wherein the plurality of control outlets include N control outlets coupled to the N pumps, whereby the controller can controls the plurality of pumps and the mixing valve to provide a plurality of different calibration solutions at the mixing valve outlet.
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Abstract
A subcutaneous sensor system includes a sensor, a plurality of reservoirs, a plurality of pumps, a mixer provided with a plurality of mixer inlets and a mixer outlet, and a controller having an input coupled to the sensor output and a plurality of control outputs coupled to the plurality of pumps and the mixer. In certain embodiments, the system further includes an enclosure for the reservoirs, the pumps, the mixer and the controller, e.g. in the form of a skin patch or in the form of an implantable enclosure. In certain embodiments, the sensor is external to the enclosure and implanted beneath the skin tissue.
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Citations
19 Claims
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1. A subcutaneous sensor system with multiple reservoirs for calibrating solutions comprising:
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a sensor having a sensor output; a plurality of reservoirs provided with a corresponding plurality of reservoir outlets, wherein there are N reservoirs and N reservoir outlets; a plurality of pumps provided with a corresponding plurality of pump inlets and a corresponding plurality of pump outlets, wherein the plurality of pump inlets are coupled to the plurality of reservoir outlets, wherein there are N pumps, N pump inlets and N pump outlets, wherein the N pump inlets are coupled to the N reservoir outlets, and wherein a first reservoir of the plurality of reservoirs contains a first calibration solution and a second reservoir of the plurality of reservoirs contains a second calibration solution different from the first calibration solution; a mixing valve provided with a plurality of mixing valve inlets and a mixing valve outlet, wherein the plurality of mixing valve inlets comprise N mixing valve inlets that are coupled to the N pump outlets and wherein the first calibration solution and the second calibration solution are mixed in the mixing valve to provide a third calibration solution that is intermediate to the first calibration solution and the second calibration solution; and a controller having an input coupled to the sensor output and a plurality of control outputs coupled to the plurality of pumps and the mixing valve, wherein the plurality of control outlets include N control outlets coupled to the N pumps, whereby the controller can controls the plurality of pumps and the mixing valve to provide a plurality of different calibration solutions at the mixing valve outlet. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A subcutaneous sensor system with multiple reservoirs for calibrating solutions comprising:
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an enclosure; a tube having a first end disposed within the enclosure and a second end disposed outside of the enclosure; a sensor disposed proximate to the second end of the tube and having a sensor output; a conductor at least partially enclosed within the tube and having a first end and a second end, the first end being coupled to the sensor output; a plurality of reservoirs disposed within the enclosure and provided with a corresponding plurality of reservoir outlets, wherein there are N reservoirs and N reservoir outlets, wherein a first reservoir of the plurality of reservoirs contains a first calibration solution and a second reservoir of the plurality of reservoirs contains a second calibration solution different from the first calibration solution; a plurality of pumps disposed within the enclosure and provided with a corresponding plurality of pump inlets and a corresponding plurality of pump outlets, wherein the plurality of pump inlets are coupled to the plurality of reservoir outlets, wherein there are N pumps, N pump inlets and N pump outlets, wherein the N pump inlets are coupled to the N reservoir outlets; a mixing valve disposed within the enclosure and provided with a plurality of mixing valve inlets and a single mixing valve outlet coupled to the first end of the tube, wherein the plurality of mixing valve inlets comprise N mixing valve inlets that are coupled to the N pump outlets, and wherein the first calibration solution and the second calibration solution are mixed in the mixing valve to provide a third calibration solution that is intermediate to the first calibration solution and the second calibration solution; and a microcontroller unit (MCU) disposed within the enclosure and having an input coupled to the second end of the conductor and a plurality of control outputs coupled to the plurality of pumps and the mixing valve, wherein the plurality of control outlets include N control outlets coupled to the N pumps. - View Dependent Claims (18, 19)
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Specification