Implantable oximetric measurement apparatus and method of use
First Claim
1. An implantable apparatus for measuring blood oxygen saturation levels in a patient, the apparatus comprising:
- a housing having a wall and an interior volume, at least a portion of the housing wall comprising an optically transparent material, the housing having a size, shape and column strength to be injected through and released from a hollow tissue penetrating device into an intramuscular target tissue site beneath a skin of the patient by the application of a force on a proximal end of the housing;
an optical emitter positioned within the housing, the emitter arranged and configured to emit light through the housing wall and into the tissue site to measure a blood oxygen saturation within the tissue site, the emitted light having at least one wavelength whose absorbance is related to a level of blood oxygen saturation;
an optical detector positioned within the housing and arranged to receive light reflected from the tissue site, the optical detector configured to detect light at the at least one wavelength and generate a detector output signal responsive to an intensity of the detected light;
a processor positioned within the housing and operably coupled to the detector and emitter to send signals to the emitter to emit light and receive the detector output signal, the processor including logic for calculating a blood oxygen saturation level using the detector output signal and generating a signal encoding the blood oxygen saturation level and logic to adjust at least of an intensity or wavelength of the emitted light to penetrate a selectable depth into tissue at the target site; and
a power source positioned within the housing for powering at least one of the processor, the emitter or the detector, the power source coupled to at least the processor.
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Accused Products
Abstract
Embodiments provide an apparatus, system, kit and method for in vivo measurement of blood oxygen saturation (BAS). One embodiment provides an implantable apparatus for measuring BAS comprising a housing, emitter, detector, processor and power source. The housing is configured to be injected through a tissue penetrating device into a target tissue site (TS). The emitter is configured to emit light into the TS to measure BAS, the emitted light having at least one wavelength (LOW) whose absorbance is related to a BAS. The detector is configured to receive light reflected from the TS, detect light at the LOW and generate a detector output signal (DOS) responsive to an intensity of the detected light. The processor is operably coupled to the detector and emitter to send signals to the emitter to emit light and receive the DOS and includes logic for calculating a BAS and generate a signal encoding the BAS.
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Citations
38 Claims
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1. An implantable apparatus for measuring blood oxygen saturation levels in a patient, the apparatus comprising:
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a housing having a wall and an interior volume, at least a portion of the housing wall comprising an optically transparent material, the housing having a size, shape and column strength to be injected through and released from a hollow tissue penetrating device into an intramuscular target tissue site beneath a skin of the patient by the application of a force on a proximal end of the housing; an optical emitter positioned within the housing, the emitter arranged and configured to emit light through the housing wall and into the tissue site to measure a blood oxygen saturation within the tissue site, the emitted light having at least one wavelength whose absorbance is related to a level of blood oxygen saturation; an optical detector positioned within the housing and arranged to receive light reflected from the tissue site, the optical detector configured to detect light at the at least one wavelength and generate a detector output signal responsive to an intensity of the detected light; a processor positioned within the housing and operably coupled to the detector and emitter to send signals to the emitter to emit light and receive the detector output signal, the processor including logic for calculating a blood oxygen saturation level using the detector output signal and generating a signal encoding the blood oxygen saturation level and logic to adjust at least of an intensity or wavelength of the emitted light to penetrate a selectable depth into tissue at the target site; and a power source positioned within the housing for powering at least one of the processor, the emitter or the detector, the power source coupled to at least the processor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 33, 36, 37)
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32. A method for measuring a blood oxygen saturation level, in a patient, the method comprising:
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penetrating a hollow tissue penetrating device through a patient'"'"'s skin to an intramuscular target tissue site; injecting through the hollow tissue penetrating device to the target tissue site in the patient an apparatus for measuring blood oxygen saturation level, wherein injecting comprises applying a sufficient force on a proximal end of the housing of the apparatus to cause a distal end of the apparatus to penetrate through tissue to reach the target tissue site; and measuring an oxygen saturation level of the target tissue site using the implanted apparatus, wherein said measuring comprises emitting light into tissue from the implanted apparatus and at least one of an intensity or wavelength of the emitted light are adjusted to penetrate a selectable depth into tissue so as to measure oxygen saturation of tissue at the selectable depth. - View Dependent Claims (34)
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35. An implantable apparatus for measuring blood oxygen saturation levels in a patient, the apparatus comprising:
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a housing having a wall, an interior volume, an atraumatic distal end and a biodegradable tissue penetrating element attached to the atraumatic distal end of the housing so that the atraumatic distal end and the biodegradable distal end can be injected attached together into tissue, at least a portion of the housing wall comprising an optically transparent material, the housing having a size, shape and column strength to be injected through and released from a hollow tissue penetrating device into a target tissue site beneath a skin of the patient by the application of a force on a proximal end of the housing;
wherein after release of the housing into tissue, the biodegradable tissue penetrating element degrades at the tissue site to reveal the atraumatic distal end of the housing;an optical emitter positioned within the housing, the emitter arranged and configured to emit light through the housing wall and into the tissue site to measure a blood oxygen saturation within the tissue site, the emitted light having at least one wavelength whose absorbance is related to a level of blood oxygen saturation; an optical detector positioned within the housing and arranged to receive light reflected from the tissue site, the optical detector configured to detect light at the at least one wavelength and generate a detector output signal responsive to an intensity of the detected light; a processor positioned within the housing and operably coupled to the detector and emitter to send signals to the emitter to emit light and receive the detector output signal, the processor including logic for calculating a blood oxygen saturation level using the detector output signal and generating a signal encoding the blood oxygen saturation level; and a power source positioned within the housing for powering at least one of the processor, the emitter or the detector, the power source coupled to at least the processor.
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38. An implantable apparatus for measuring blood oxygen saturation levels in a patient, the apparatus comprising:
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a housing having a wall and an interior volume, at least a portion of the housing wall comprising an optically transparent material, the housing having a size, shape and column strength to be injected through and released from a hollow tissue penetrating device into an intramuscular tissue site beneath a skin of the patient by the application of a force on a proximal end of the housing; an optical emitter positioned within the housing, the emitter arranged and configured to emit light through the housing wall and into the tissue site to measure a blood oxygen saturation within the tissue site, the emitted light having at least one wavelength whose absorbance is related to a level of blood oxygen saturation; an optical detector positioned within the housing and arranged to receive light reflected from the tissue site, the optical detector configured to detect light at the at least one wavelength and generate a detector output signal responsive to an intensity of the detected light;
wherein the optical detector and optical emitter are linearly arranged with respect to a length of the housing and recessed below the housing wall so as to produce a selected angle of light incidence and reflection with a target tissue site;a processor positioned within the housing and operably coupled to the detector and emitter to send signals to the emitter to emit light and receive the detector output signal, the processor including logic for calculating a blood oxygen saturation level using the detector output signal and generating a signal encoding the blood oxygen saturation level; and a power source positioned within the housing for powering at least one of the processor, the emitter or the detector, the power source coupled to at least the processor.
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Specification