Stable emulsion for prevention of skin irritation and items using same

• US 9,949,902 B2
• Filed: 06/24/2013
• Issued: 04/24/2018
• Est. Priority Date: 06/29/2012
• Status: Active Grant

• Current Assignee: Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation)
• Original Assignee: Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation)
• Inventors: Mundschau, Stacy Averic, Kieffer, Philip Eugene, Cunningham, Corey Thomas
• Primary Examiner(s): Pak, John
• Assistant Examiner(s): BRANSON, DANIEL L
• Application Number:
  US13/925,316
• Publication Number:
  US 20140004164A1
• Time in Patent Office: 1,765 Days
• CPC Class Codes: A61K 2800/594 Mixtures of polymers
• CPC Class Codes: A61K 2800/75 Anti-irritant
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/06 Emulsions
• CPC Class Codes: A61K 8/062 Oil-in-water emulsions
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61K 8/342 Alcohols having more than seven atoms in an unbroken chain
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/4973 with oxygen as the only hetero atom
• CPC Class Codes: A61K 8/55 Phosphorus compounds
• CPC Class Codes: A61K 8/602 Glycosides, e.g. rutin
• CPC Class Codes: A61K 8/73 Polysaccharides
• CPC Class Codes: A61K 8/733 Alginic acid; Salts thereof
• CPC Class Codes: A61K 8/737 Galactomannans, e.g. guar; Derivatives thereof
• CPC Class Codes: A61K 8/891 saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
• CPC Class Codes: A61K 8/92 Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

An emulsion suitable for incorporation into wet wipes used to clean urine and fecal matter from the skin. The emulsion includes silicone oil and water-soluble zinc salt such as zinc chloride and zinc sulfate. Phase separation is prevented with an emulsification system that includes a gum blend and salt-tolerant emulsifier. The gum blend includes at least one gum and propylene glycol alginate.

Claims

1. An emulsion for the prevention of skin irritation, the emulsion comprising:

a salt-tolerant emulsifier;

a gum blend comprising a gum and propylene glycol alginate, wherein the gum blend is 0.01% to 0.5% by weight of the emulsion;

1% to 10% by weight silicone oil;

90% to 98% by weight water;

0.20% to 10% by weight water-soluble zinc salt,

a pH adjusting agent in an amount to bring the emulsion to a pH of 4 to 7, and

a preservative selected from the group consisting of phenoxyethanol, benzethonium chloride, benzisothiazolinone, benzyl alcohol, 2-Bromo-2-nitropropane-1,3-diol, butylparaben, caprylyl glycol, chlorhexidine digluconate, DMDM hydantoin, diazolidinyl urea, dehydroacetic acid, ethylparaben, iodopropynyl butylcarbamate, methylchloroisothiazolinone, methylisothiazolinone, methyldibromo glutaronitrile, methylparaben, pentylene glycol, phenethyl alcohol, phenoxyethanol, propylparaben, polyaminopropyl biguanide, quaternium-15, salicylic acid, sodium methylparaben, sodium dehydroacetate, thymol, triclosan and mixtures thereof.

2. The emulsion of claim 1 wherein the salt-tolerant emulsifier comprises a phosphate ester and/or a Gemini surfactant limited to the oil phase.

3. The emulsion of claim 1 wherein the silicone oil consists of dimethicone.

4. The emulsion of claim 1 wherein the silicone oil is selected from the group consisting of dimethicone, amodimethicone and derivatives thereof, dimethiconol, cyclomethicone, stearyl dimethicone, behenyl dimethicone, phenyl trimethicone and combinations thereof.

5. The emulsion of claim 1 having a viscosity of less than 5000 centipoise.

6. The emulsion of claim 1 wherein the gum consists of xanthan gum and guar gum.

7. The emulsion of claim 1 wherein the gum is selected from the group consisting of xanthan gum, guar gum, gellan gum, acacia gum, cellulose gum, dehydroxanthan gum, sclerotium gum, locust bean gum and combinations thereof.

8. A wet wipe comprising a substrate with the emulsion of claim 6 deposited thereon.

9. A wet wipe comprising:

a substrate having an emulsion deposited thereon, the emulsion comprising;

a salt-tolerant emulsifier;

a gum blend comprising a gum and propylene glycol alginate, wherein the gum blend is 0.01% to 0.5% by weight of the emulsion;

1% to 10% by weight silicone oil;

90% to 98% by weight water;

at least 0.25% by weight water-soluble zinc salt,

a pH adjusting agent in an amount to bring the emulsion to a pH of 4 to 7, and

a preservative selected from the group consisting of phenoxyethanol, benzethonium chloride, benzisothiazolinone, benzyl alcohol, 2-Bromo-2-nitropropane-1,3-diol, butylparaben, caprylyl glycol, chlorhexidine digluconate, DMDM hydantoin, diazolidinyl urea, dehydroacetic acid, ethylparaben, iodopropynyl butylcarbamate, methylchloroisothiazolinone, methylisothiazolinone, methyldibromo glutaronitrile, methylparaben, pentylene glycol, phenethyl alcohol, phenoxyethanol, propylparaben, polyaminopropyl biguanide, quaternium-15, salicylic acid, sodium methylparaben, sodium dehydroacetate, thymol, triclosan and mixtures thereof.

10. The wet wipe of claim 9 wherein the gum is selected from the group consisting of xanthan gum, guar gum, gellan gum, acacia gum, cellulose gum, dehydroxanthan gum, sclerotium gum, locust bean gum and combinations thereof.

11. The wet wipe of claim 9 wherein the silicone oil is selected from the group consisting of dimethicone, amodimethicone and derivatives thereof, dimethiconol, cyclomethicone, stearyl dimethicone, behenyl dimethicone, phenyl trimethicone and combinations thereof.

12. The wet wipe of claim 9 wherein the emulsion contains 94% to 98% by weight water.

13. The wet wipe of claim 9 wherein the gums are xanthan gum and guar gum, and the silicone oil is dimethicone.

14. The wet wipe of claim 9 wherein the substrate is a non-woven material.

15. The wet wipe of claim 9 wherein the substrate comprises woven fabric, spunbonded fabric, meltblown fabric, knit fabric, wet-laid fabric, scrims or needle-punched webs.