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Controlled release formulations for the delivery of HIF-1 inhibitors

  • US 9,950,072 B2
  • Filed: 01/19/2015
  • Issued: 04/24/2018
  • Est. Priority Date: 03/16/2012
  • Status: Active Grant
First Claim
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1. Micro- and/or nanoparticles formed of polymeric conjugates defined by one of the following formulae
(A-X)m

  • Y—

    ((Z)o

    (X)p-(A)q)n whereinA represents, independently for each occurrence, a HIF-1 inhibitor;

    X represents, independently for each occurrence, a hydrophobic polymer segment;

    Y is absent, or represents a branch point;

    Z represents, independently for each occurrence, a hydrophilic polymer segment; and

    o is 1;

    p and q are independently 0 or 1;

    m is an integer between one and twenty; and

    n is an integer between one and twenty.

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