System for providing stimulation pattern to modulate neural activity

• US 9,950,170 B2
• Filed: 03/28/2016
• Issued: 04/24/2018
• Est. Priority Date: 12/24/2003
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Libbus, Imad, Kramer, Andrew P.
• Primary Examiner(s): Stice, Paula J
• Application Number:
  US15/083,011
• Publication Number:
  US 20160279422A1
• Time in Patent Office: 757 Days
• Field of Search: 607 30, 607 44
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/3611 Respiration control stimulating respiratory organs A61N1/3601
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/3614 based on impedance measurement
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36535 controlled by body position or posture
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/3655 controlled by body or blood temperature
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/36571 controlled by blood flow rate, e.g. blood velocity or cardiac output
• CPC Class Codes: A61N 1/37288 Communication to several implantable medical devices within one patient

Abstract

A system embodiment comprises an implantable device including controller circuitry, memory, a transceiver, and a generator configured to generate electrical stimulation to modulate the neural activity. The controller circuitry and the transceiver configured to cooperate to receive, from another device, data corresponding to a user-programmable stimulation pattern and store the data in the memory. The user-programmable pattern includes a programmable pattern of bursts with multiple burst durations and multiple burst interval sequences, and the bursts include pulses with a user-programmable wave morphology. The controller circuitry is operably connected to the memory and the generator to use the data stored in the memory to control generation of the electrical stimulation to provide the user-programmable stimulation pattern that includes the pulses with the user-programmable wave morphology and that includes the multiple burst durations and the multiple burst interval sequences.

Claims

1. A system for use with an electrode, comprising:

an implantable device configured to use the electrode to modulate neural activity, the implantable device comprising controller circuitry, memory, a transceiver, and a generator configured to generate electrical stimulation to modulate the neural activity;

the controller circuitry and the transceiver configured to cooperate to receive, from another device, data corresponding to a user-programmable stimulation pattern and store the data in the memory, wherein the user-programmable pattern includes a programmable pattern of bursts with multiple burst durations and multiple burst interval sequences, and the bursts include pulses with a user-programmable wave morphology, the programmable pattern of bursts with multiple burst durations and multiple burst interval sequences being different from a simple burst pattern of repeated bursts with one burst duration and burst interval; and

the controller circuitry operably connected to the memory and the generator to use the data stored in the memory to control generation of the electrical stimulation to provide the user-programmable stimulation pattern that includes the pulses with the user-programmable wave morphology and that includes the multiple burst durations and the multiple burst interval sequences.

2. The system of claim 1, wherein the memory is configured to store a user-programmable schedule, and instructions for controlling the generator to generate the user-programmable stimulation pattern according to the user-programmable schedule, and the controller circuitry is operably connected to the memory and the generator to use the instructions stored in the memory to control generation of the programmable stimulation pattern according to the user-programmable schedule.

3. The system of claim 1, wherein the memory includes the data corresponding to the user-programmable stimulation pattern, and the user-programmable wave morphology includes a morphology that includes harmonic components to mimic naturally-occurring neural activity, the controller circuitry operably connected to the memory and the generator to use the data stored in the memory to control generation of the electrical stimulation to provide the morphology that includes the harmonic components to mimic naturally-occurring neural activity.

4. The system of claim 1, wherein the memory includes the data corresponding to the user-programmable stimulation pattern, and the user-programmable wave morphology includes a morphology selected from the group of morphologies consisting of:

a square wave; and

at least one of a triangle wave or a sinusoidal wave,

the controller circuitry operably connected to the memory and the generator to use the data stored in the memory to control generation of the electrical stimulation to provide the morphology that includes the square wave and at least one of the triangle wave or the sinusoidal wave.

5. The system of claim 1, wherein the memory includes the data corresponding to the user-programmable stimulation pattern, and the user-programmable pattern includes a duty cycle for a stimulation ON time during which electrical stimulation is generated and a stimulation OFF time during which electrical stimulation is not generated,

the controller circuitry operably connected to the memory and the generator to use the data stored in the memory to control generation of the electrical stimulation to provide the duty cycle.

6. The system of claim 1, wherein the memory includes a circadian rhythm template, and the controller circuitry and the generator are configured to cooperate to use the circadian rhythm template to modulate the user-programmable pattern.

7. The system of claim 1, further comprising a body temperature sensor, wherein the controller circuitry and the generator are configured to cooperate to use body temperature sensed by the body temperature sensor to modulate the user-programmable pattern.

8. The system of claim 1, further comprising a sensor to sense a physiological parameter where the sensor is selected from the group of sensors consisting of:

an electroencephalogram (EEG) sensor, an electrocardiogram (ECG) sensor, and electromyogram (EMG) sensor, or a muscle tone sensor, wherein the controller circuitry and the generator are configured to cooperate to use the sensed physiological parameter to modulate the user-programmable pattern.

9. The system of claim 1, further comprising a physiological sensor to sense a physiological parameter, wherein the controller circuitry and the generator are configured to cooperate to modulate at least one stimulation parameter in response to the sensed physiological parameter, wherein the at least one stimulation parameter is selected from the group of parameters for the electrical energy consisting of:

an amplitude, a frequency, and a burst frequency.

10. The system of claim 1, further comprising a patient posture sensor, wherein the controller circuitry and the generator are configured cooperate to use patient posture sensed by the patient posture sensor to modulate the user-programmable pattern.

11. The system of claim 1, further comprising an activity sensor, wherein the controller circuitry and the generator are configured to cooperate to use patient activity sensed by the activity sensor to modulate the user-programmable pattern.

12. The system of claim 1, wherein the controller circuitry is configured to determine a time of day, and the controller circuitry and the generator are configured to cooperate to use the time of day to modulate the user-programmable pattern.

13. The system of claim 1, further comprising an activity sensor, wherein the controller circuitry and the generator are configured to cooperate to use patient activity sensed by both the activity sensor and a time of day to modulate the user-programmable pattern.

14. A method, comprising:

using an implantable device operably connected to an electrode to modulate neural activity, wherein the implantable device comprises controller circuitry, memory, a transceiver, and a generator configured to generate electrical stimulation to modulate the neural activity using the electrode;

using the controller circuitry and the transceiver to receive, from another device, data corresponding to a user-programmable stimulation pattern and storing the data in the memory, wherein the user-programmable pattern includes a programmable pattern of bursts with multiple burst durations and multiple burst interval sequences, and the bursts include pulses with a user-programmable wave morphology, the programmable pattern of bursts with multiple burst durations and multiple burst interval sequences being different from a simple burst pattern of repeated bursts with one burst duration and burst interval; and

using the controller circuitry, the generator and the data stored in the memory to control generation of the electrical stimulation to provide the user-programmable stimulation pattern that includes the pulses with the user-programmable wave morphology and that includes the multiple burst durations and the multiple burst interval sequences.

15. The method of claim 14, wherein the user-programmable wave morphology includes a morphology that includes harmonic components to mimic naturally-occurring neural activity.

16. The method of claim 14, wherein the user-programmable wave morphology includes a morphology selected from the group of morphologies consisting of:

a square wave; and

at least one of a triangle wave or a sinusoidal wave.

17. The method of claim 14, wherein the user-programmable pattern includes a duty cycle for a stimulation ON time during which electrical stimulation is generated and a stimulation OFF time during which electrical stimulation is not generated.

18. The method of claim 14, further comprising using a time of day or a circadian rhythm template to modulate the use-programmable pattern.

19. The method of claim 14, further comprising using a patient posture sensor to sense patient posture, and using the sensed patient posture to modulate the user-programmable pattern.

20. The method of claim 14, further comprising using an activity sensor to sense patient active, and using the sensed patient activity to modulate the user-programmable pattern.