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Stabilized compounds having secondary structure motifs

  • US 9,951,099 B2
  • Filed: 10/06/2016
  • Issued: 04/24/2018
  • Est. Priority Date: 05/18/1999
  • Status: Expired due to Term
First Claim
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1. A method for synthesizing a peptide comprising a cross-link, the method comprising:

  • (a) synthesizing an amino acid sequence, wherein the amino acid sequence comprises a first amino acid comprising a first moiety and a second amino acid comprising a second moiety, and wherein the first and second moieties are reactive toward one another in the presence of a catalyst; and

    (b) reacting the amino acid sequence under conditions sufficient to promote a reaction between the first and second moieties toward each other in the presence of the catalyst, thereby resulting in formation of the cross-link in the peptide;

    wherein the cross-link spans one or two turns of an α

    -helix;

    the cross-link comprises a carbon-carbon double bond; and

    the peptide disrupts binding of p53 to MDM2.

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