Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
First Claim
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1. An isolated antibody having a higher affinity to Aβ
- (1-42) globulomer than to at least one amyloid beta protein selected from the group consisting of a) Aβ
(1-42) peptide present in cerebrospinal fluid (CSF) and b) Aβ
(1-40) peptide present in CSF, wherein the antibody comprises;
(i) the amino acid sequences of the Complementary Determining Region (CDR) 1, CDR2, and CDR3 of the heavy chain variable region (VH) of SEQ ID NO;
5 and the amino acid sequences of the CDR1, CDR2, and CDR3 of the light chain variable region (VL) of SEQ ID NO;
6, or(ii) the amino acid sequences of the CDR1, CDR2, and CDR3 of the heavy chain variable region (VH) of SEQ ID NO;
7 and the amino acid sequences of the CDR1, CDR2, and CDR3 of the light chain variable region (VL) of SEQ ID NO;
8.
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Abstract
The subject invention relates to monoclonal antibodies that may be used in the treatment and diagnosis of Alzheimer'"'"'s Disease. In particular, the present invention relates to monoclonal antibodies referred to as 10F4 and 3C5 and to other monoclonal antibodies (e.g., murine, human or humanized) having similar properties thereto.
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Citations
19 Claims
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1. An isolated antibody having a higher affinity to Aβ
- (1-42) globulomer than to at least one amyloid beta protein selected from the group consisting of a) Aβ
(1-42) peptide present in cerebrospinal fluid (CSF) and b) Aβ
(1-40) peptide present in CSF, wherein the antibody comprises;(i) the amino acid sequences of the Complementary Determining Region (CDR) 1, CDR2, and CDR3 of the heavy chain variable region (VH) of SEQ ID NO;
5 and the amino acid sequences of the CDR1, CDR2, and CDR3 of the light chain variable region (VL) of SEQ ID NO;
6, or(ii) the amino acid sequences of the CDR1, CDR2, and CDR3 of the heavy chain variable region (VH) of SEQ ID NO;
7 and the amino acid sequences of the CDR1, CDR2, and CDR3 of the light chain variable region (VL) of SEQ ID NO;
8. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
- (1-42) globulomer than to at least one amyloid beta protein selected from the group consisting of a) Aβ
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2. An isolated antibody having a higher affinity to Aβ
- (1-42) globulomer than to at least one amyloid beta protein selected from the group consisting of a) Aβ
(1-42) peptide present in cerebrospinal fluid (CSF), and b) Aβ
(1-40) peptide present in CSF, wherein the antibody comprises;(i) the amino acid sequences of the VH CDR1 VH CDR2 VH CDR3 VL CDR1 VL CDR2, and VL CDR3 of a monoclonal antibody (10F4) obtainable from a hybridoma designated by American Type Culture Collection (ATCC) deposit number PTA-7808, or (ii) the amino acid sequences of the VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2, and VL CDR3 of a monoclonal antibody (3C5) obtainable from a hybridoma designated by ATCC deposit number PTA-7406.
- (1-42) globulomer than to at least one amyloid beta protein selected from the group consisting of a) Aβ
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19. An isolated antibody produced by the hybridoma having ATCC deposit number PTA-7406 or PTA-7808.
Specification