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Aβ conformer selective anti-Aβ globulomer monoclonal antibodies

  • US 9,951,125 B2
  • Filed: 05/16/2016
  • Issued: 04/24/2018
  • Est. Priority Date: 11/30/2006
  • Status: Active Grant
First Claim
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1. An isolated antibody having a higher affinity to Aβ

  • (1-42) globulomer than to at least one amyloid beta protein selected from the group consisting of a) Aβ

    (1-42) peptide present in cerebrospinal fluid (CSF) and b) Aβ

    (1-40) peptide present in CSF, wherein the antibody comprises;

    (i) the amino acid sequences of the Complementary Determining Region (CDR) 1, CDR2, and CDR3 of the heavy chain variable region (VH) of SEQ ID NO;

    5 and the amino acid sequences of the CDR1, CDR2, and CDR3 of the light chain variable region (VL) of SEQ ID NO;

    6, or(ii) the amino acid sequences of the CDR1, CDR2, and CDR3 of the heavy chain variable region (VH) of SEQ ID NO;

    7 and the amino acid sequences of the CDR1, CDR2, and CDR3 of the light chain variable region (VL) of SEQ ID NO;

    8.

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