Cassette system integrated apparatus

• US 9,951,768 B2
• Filed: 03/23/2015
• Issued: 04/24/2018
• Est. Priority Date: 02/27/2007
• Status: Active Grant

• Current Assignee: Deka Products Limited Partnership
• Original Assignee: Deka Products Limited Partnership
• Inventors: Grant, Kevin L., Dale, James D., Demers, Jason A., Wilt, Michael J.
• Primary Examiner(s): Venkatesan, Umashankar
• Application Number:
  US14/666,059
• Publication Number:
  US 20150196698A1
• Time in Patent Office: 1,128 Days
• Field of Search: 137833, 137 99, 137100, 1375653, 4174772, 417479, 417480
• CPC Class Codes: A61M 1/154 with sensing means or components thereof
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/1561 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/15625 the reservoirs acting as balance chambers
• CPC Class Codes: A61M 1/1565 Details of valves
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1605 Physical characteristics of the dialysate fluid
• CPC Class Codes: A61M 1/1639 linked by membranes
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1664 with temperature control
• CPC Class Codes: A61M 1/1666 by dissolving solids
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/128 with incorporated valves
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3324 PH measuring means
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 60/113 in other functional devices, e.g. dialysers or heart-lung machines
• CPC Class Codes: A61M 60/268 the displacement member being flexible, e.g. membranes, diaphragms or bladders
• CPC Class Codes: A61M 60/37 Haemodialysis, haemofiltration or diafiltration
• CPC Class Codes: A61M 60/427 : the force acting on the blood contacting member being hydraulic or pneumatic
• CPC Class Codes: A61M 60/43 : using vacuum at the blood pump, e.g. to accelerate filling
• CPC Class Codes: A61M 60/837 : Aspects of flexible displacement members, e.g. shapes or materials
• CPC Class Codes: A61M 60/847 : arranged in a cassette
• CPC Class Codes: A61M 60/849 : Disposable parts
• CPC Class Codes: A61M 60/851 : Valves
• CPC Class Codes: A61M 60/892 : Active valves, i.e. actuated by an external force
• CPC Class Codes: A61M 60/894 : Passive valves, i.e. valves actuated by the blood
• CPC Class Codes: F04B 13/02 : of two or more fluids at the same time
• CPC Class Codes: F04B 23/06 : the pumps being all of reciprocating positive-displacement type
• CPC Class Codes: F04B 41/06 : Combinations of two or more pumps
• CPC Class Codes: F04B 43/00 : Machines, pumps, or pumping installations having flexible working members pumps or pumping installations specially adapted for elastic fluids F04B45/00
• CPC Class Codes: F04B 43/026 : each plate-like pumping flexible member working in its own pumping chamber
• CPC Class Codes: F04B 43/06 : Pumps having fluid drive
• CPC Class Codes: F04B 43/0736 : with two or more pumping chambers in parallel
• CPC Class Codes: F04B 45/02 : having bellows
• CPC Class Codes: F04B 45/0536 : the actuating fluid being controlled by one or more valves
• CPC Class Codes: F04B 49/02 : Stopping, starting, unloading or idling control
• CPC Class Codes: F04B 49/22 : by means of valves F04B49/03 takes precedence
• CPC Class Codes: F04B 53/06 : Venting
• CPC Class Codes: F04B 53/10 : Valves; Arrangement of valves
• CPC Class Codes: F04B 53/16 : Casings; Cylinders; Cylinder liners or heads; Fluid connections
• CPC Class Codes: F04B 7/02 : the valving being fluid-actuated
• CPC Class Codes: F04B 9/109 : having plural pumping chambers
• CPC Class Codes: F17D 3/00 : Arrangements for supervising or controlling working operations
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
• CPC Class Codes: Y10T 137/0324 : With control of flow by a condition or characteristic of a fluid
• CPC Class Codes: Y10T 137/0379 : By fluid pressure
• CPC Class Codes: Y10T 137/2521 : Flow comparison or differential response
• CPC Class Codes: Y10T 137/85978 : With pump
• CPC Class Codes: Y10T 137/86139 : Serial

Abstract

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

Claims

1. A pump cassette for controlling flow of a fluid comprising one or more pneumatically actuated diaphragm pumps and diaphragm valves, the pump cassette comprising an assembly of:

a middle plate interposed between a top plate and a bottom plate, and having a first side facing the top plate and a second opposing side facing the bottom plate;

the top plate and middle plate defining a first group of fluid flow paths;

the bottom plate and middle plate defining a first group of pneumatic actuation paths;

the middle plate comprising a first group of valve and pump regions,

wherein for the first group of valve and pump regions;

each said pump region comprises and is delimited by an aperture in the middle plate and is configured to hold a flexible pump diaphragm over the aperture to separate a pump fluid chamber bounded by the pump diaphragm and the top plate from a pump pneumatic actuation chamber bounded by the pump diaphragm and the bottom plate; and

wherein each said pump pneumatic actuation chamber is fluidly connected to one or more of said first group of pneumatic actuation paths, and each said pump fluid chamber is fluidly connected to one or more of said first group of fluid flow paths.

2. The pump cassette of claim 1, further comprising a first group of pneumatic control ports, wherein each pneumatic control port of said first group of pneumatic control ports is fluidly connected to one or more of said pneumatic actuation chambers of the first group of valve and pump regions.

3. The pump cassette of claim 2, wherein each said pneumatic control port of the first group of pneumatic control ports is formed in the bottom plate.

4. The pump cassette of claim 1, further comprising a first group of fluid inlet or outlet ports, wherein each fluid inlet or outlet port of said first group of fluid inlet or outlet ports is fluidly connected to one or more of said fluid chambers and one or more of valve fluid chambers of the first group of valve and pump regions.

5. The pump cassette of claim 1, wherein:

the top plate and middle plate define a second group of pneumatic actuation paths;

the bottom plate and middle plate define a second group of fluid flow paths;

the middle plate comprises a second group of valve or pump regions;

and wherein for the second group of valve or pump regions;

each said valve region comprises a flexible valve diaphragm that separates a valve fluid chamber bounded by the valve diaphragm and the middle plate from a valve pneumatic actuation chamber bounded by the valve diaphragm and the top plate; and

wherein each valve pneumatic actuation chamber of the second group of valve or pump regions is fluidly connected to one or more of said second group of pneumatic actuation paths, and each valve fluid chamber of the second group of valve or pump regions is fluidly connected to one or more of said second group of fluid flow paths.

6. The pump cassette of claim 5, further comprising a second group of pneumatic control ports, wherein each pneumatic control port of said second group of pneumatic control ports is fluidly connected to one or more of said pneumatic actuation chambers of the second group of valve or pump regions.

7. The pump cassette of claim 6, wherein each said pneumatic control port of the second group of pneumatic control ports is formed in the top plate.

8. The pump cassette of claim 5, further comprising a second group of fluid inlet or outlet ports, wherein each fluid inlet or outlet port of the second group of fluid inlet or outlet ports is fluidly connected to one or more fluid chambers of the second group of valve or pump regions.

18. The pump cassette of claim 1, wherein all valves fluidically connected to any one of the diaphragm pumps are pneumatically actuated only through one or more of the first group of pneumatic actuation paths.

20. The pump cassette of claim 1, wherein each said valve region comprises a flexible valve diaphragm that separates a valve fluid chamber bounded by the valve diaphragm and the middle plate from a valve pneumatic actuation chamber bounded by the valve diaphragm and the bottom plate, and wherein each said valve pneumatic actuation chamber is fluidly connected to one or more of said first group of pneumatic actuation paths, and each said valve fluid chamber is fluidly connected to one or more of said first group of fluid flow paths.

22. The pump cassette of claim 5, wherein all valves fluidically connected to any one of the diaphragm pumps of the second group of valve or pump regions are pneumatically actuated only through one or more of the second group of pneumatic actuation paths.

24. The cassette assembly of claim 1 wherein the first and second sides of the middle plate have a width and length greater than a thickness of the middle plate, and wherein the first group of fluid flow paths run parallel to the first or second side of the middle plate.

26. The cassette assembly of claim 1, wherein no portion of the first group of fluid flow paths running parallel to the first or second side of the middle plate is entirely contained within and surrounded by the middle plate.

9. A cassette assembly comprising a first, second and third cassette, the second cassette comprising one or more pneumatically actuated diaphragm pumps and diaphragm valves, the second cassette being interposed between the first and third cassettes, and said first, second and third cassettes being fluidly interconnected by a plurality of conduits;

the second cassette comprising an assembly of;

a middle plate interposed between a top plate and a bottom plate, and having a first side facing the top plate and a second opposing side facing the bottom plate;

the top plate and middle plate defining a first group of fluid flow paths;

the bottom plate and middle plate defining a first group of pneumatic actuation paths;

the middle plate comprising a first group of valve and pump regions,

wherein for the first group of valve and pump regions;

each said pump region comprises and is delimited by an aperture in the middle plate and is configured to hold a flexible pump diaphragm over the aperture to separate a pump fluid chamber bounded by the pump diaphragm and the top plate from a pump pneumatic actuation chamber bounded by the pump diaphragm and the bottom plate; and

wherein each said pump pneumatic actuation chamber is fluidly connected to one or more of said first group of pneumatic actuation paths, and each said pump fluid chamber is fluidly connected to one or more of said first group of fluid flow paths.

10. The cassette assembly of claim 9, further comprising a first group of pneumatic control ports, wherein each pneumatic control port of said first group of pneumatic control ports is fluidly connected to one or more of said pneumatic actuation chambers of the first group of valve and pump regions.

11. The cassette assembly of claim 10, wherein each said pneumatic control port of the first group of pneumatic control ports is formed in the bottom plate.

12. The cassette assembly of claim 9, further comprising a first group of fluid inlet or outlet ports, wherein each fluid inlet or outlet port of said first group of fluid inlet or outlet ports is fluidly connected to one or more of said pump fluid chambers and one or more of valve fluid chambers of the first group of valve and pump regions.

13. The cassette assembly of claim 9, wherein:

the top plate and middle plate define a second group of pneumatic actuation paths;

the bottom plate and middle plate define a second group of fluid flow paths;

the middle plate comprises a second group of valve or pump regions;

and wherein for the second group of valve or pump regions;

each said valve region comprises a flexible valve diaphragm that separates a valve fluid chamber bounded by the valve diaphragm and the middle plate from a valve pneumatic actuation chamber bounded by the valve diaphragm and the top plate; and

wherein each valve pneumatic actuation chamber of the second group of valve or pump regions is fluidly connected to one or more of said second group of pneumatic actuation paths, and each valve fluid chamber of the second group of valve or pump regions is fluidly connected to one or more of said second group of fluid flow paths.

14. The cassette assembly of claim 13, further comprising a second group of pneumatic control ports, wherein each pneumatic control port of said second group of pneumatic control ports is fluidly connected to one or more pneumatic actuation chambers of the second group of valve or pump regions.

15. The cassette assembly of claim 14, wherein each said pneumatic control port of the second group of pneumatic control ports is formed in the top plate.

16. The cassette assembly of claim 13, further comprising a second group of fluid inlet or outlet ports, wherein each fluid inlet or outlet port of the second group of fluid inlet or outlet ports is fluidly connected to one or more fluid chambers of the second group of valve or pump regions.

17. The cassette assembly of claim 9, wherein one or more conduits of said plurality of conduits is rigid.

19. The cassette assembly of claim 9, wherein all valves fluidically connected to any one of the diaphragm pumps are pneumatically actuated only through one or more of the first group of pneumatic actuation paths.

21. The cassette assembly of claim 9, wherein each said valve region comprises a flexible valve diaphragm that separates a valve fluid chamber bounded by the valve diaphragm and the middle plate from a valve pneumatic actuation chamber bounded by the valve diaphragm and the bottom plate, and wherein each said valve pneumatic actuation chamber is fluidly connected to one or more of said first group of pneumatic actuation paths, and each said valve fluid chamber is fluidly connected to one or more of said first group of fluid flow paths.

23. The cassette assembly of claim 13, wherein all valves fluidically connected to any one of the diaphragm pumps of the second group of valve or pump regions are pneumatically actuated only through one or more of the second group of pneumatic actuation paths.

25. The cassette assembly of claim 9, wherein the first and second sides of the middle plate have a width and length greater than a thickness of the middle plate, and wherein the first group of fluid flow paths run parallel to the first or second side of the middle plate.

27. The cassette assembly of claim 9, wherein no portion of the first group of fluid flow paths running parallel to the first or second side of the middle plate is entirely contained within and surrounded by the middle plate.

28. A pump cassette for controlling flow of a fluid comprising one or more pneumatically actuated diaphragm pumps and diaphragm valves, the pump cassette comprising an assembly of:

a middle plate interposed between a top plate and a bottom plate, and having a first side facing the top plate and a second opposing side facing the bottom plate;

the top plate and middle plate defining a first fluid flow path that connects a diaphragm pump with one or more diaphragm valves of a first group of pumps and valves;

the bottom plate and middle plate defining a pneumatic actuation chamber for each said diaphragm pump and said one or more diaphragm valves of said first group of pumps and valves;

the middle plate including an aperture delimiting a region forming the diaphragm pump of said first group of pumps and valves, and a pair of valve ports fluidly connecting the first and second sides of the middle plate for each diaphragm valve of said first group of valves,

wherein for the first group of pumps and valves;

the middle plate is configured to hold a flexible pump diaphragm over the aperture forming a pump actuation chamber bounded by the pump diaphragm and the bottom plate, and a pump fluid pumping chamber bounded by the pump diaphragm and the top plate; and

each pair of valve ports is configured to be covered by a flexible valve diaphragm on the second side of the middle plate, an actuation chamber of said diaphragm valve being bounded by the valve diaphragm and the bottom plate.

29. The pump cassette of claim 28, wherein:

the bottom plate and middle plate define a second fluid flow path that connects a diaphragm pump with one or more diaphragm valves of a second group of pumps and valves;

the top plate and middle plate defining a pneumatic actuation chamber for each said diaphragm pump and said one or more diaphragm valves of said second group of pumps and valves;

the middle plate including an aperture delimiting a region forming the diaphragm pump of said second group of pumps and valves, and a pair of valve ports fluidly connecting the first and second sides of the middle plate for each diaphragm valve of said second group of valves,

wherein for the second group of pumps and valves;

the middle plate is configured to hold a flexible pump diaphragm over the aperture, forming a pump actuation chamber bounded by the pump diaphragm and the top plate, and a pump fluid pumping chamber bounded by the pump diaphragm and the bottom plate; and

each pair of valve ports is configured to be covered by a flexible valve diaphragm on the first side of the middle plate, an actuation chamber of said diaphragm valve being bounded by the valve diaphragm and the top plate.