Non-stationary feature relationship parameters for awareness monitoring
First Claim
1. A system for determining awareness information comprising:
- an input configured for receiving an electrophysiological signal from an electrode attached to a subject;
a display; and
one or more processors configured for;
transforming the electrophysiological signal based on a wavelet transform to generate a non-stationary transformed signal that comprises at least a time component and a scale component;
identifying a first ridge in the non-stationary transformed signal that varies in scale over time;
identifying a second ridge in the non-stationary transformed signal that varies in scale over time, wherein the first ridge is related to the second ridge;
determining a non-stationary relationship parameter over time based on a third or higher order spectral analysis, the first ridge, and the second ridge, wherein the non-stationary relationship parameter is indicative of the relationship between the first ridge and the second ridge;
determining a level of awareness of the subject based on the non-stationary relationship parameter; and
presenting information, via the display, regarding the determined level of awareness.
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Abstract
Methods and systems are presented for determining physiological information in a physiological monitor. A physiological signal (e.g., an EEG signal) received from a subject is wavelet transformed and first and second related features that vary in scale over time are identified in the transformed signal. First and second coupled ridges of the respective first and second related features may also be identified in the transformed signal. A non-stationary relationship parameter is determined and is indicative of the relationship between the first and second features and/or between the first and second ridges. Physiological information, which may be indicative of a level of awareness of a subject, is determined based on the non-stationary relationship parameter. This physiological information may be used, for example, in an operating room to monitor/regulate the subject'"'"'s anesthetic state while under general anesthesia or in an intensive care unit to monitor the subject'"'"'s sedateness and administer medication accordingly.
83 Citations
17 Claims
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1. A system for determining awareness information comprising:
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an input configured for receiving an electrophysiological signal from an electrode attached to a subject; a display; and one or more processors configured for; transforming the electrophysiological signal based on a wavelet transform to generate a non-stationary transformed signal that comprises at least a time component and a scale component; identifying a first ridge in the non-stationary transformed signal that varies in scale over time; identifying a second ridge in the non-stationary transformed signal that varies in scale over time, wherein the first ridge is related to the second ridge; determining a non-stationary relationship parameter over time based on a third or higher order spectral analysis, the first ridge, and the second ridge, wherein the non-stationary relationship parameter is indicative of the relationship between the first ridge and the second ridge; determining a level of awareness of the subject based on the non-stationary relationship parameter; and presenting information, via the display, regarding the determined level of awareness. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for determining awareness information comprising:
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receiving from an input an electrophysiological signal from an electrode attached to a subject; transforming, using one or more processors, the electrophysiological signal based on a wavelet transform to generate a non-stationary transformed signal that comprises at least a time component and a scale component; identifying, using one or more processors, a first ridge in the non-stationary transformed signal that varies in scale over time; identifying, using one or more processors, a second ridge in the non-stationary transformed signal that varies in scale over time, wherein the first ridge is related to the second ridge; determining, using one or more processors, a non-stationary relationship parameter over time based on a third or higher order spectral analysis, the first ridge, and the second ridge, wherein the non-stationary relationship parameter is indicative of the relationship between the first ridge and the second ridge; determining, using one or more processors, a level of awareness of the subject based on the non-stationary relationship parameter; and displaying, via a display, information regarding the determined level of awareness. - View Dependent Claims (15, 16, 17)
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Specification