Automatic fluid container switching in a blood processing system

• US 9,956,141 B2
• Filed: 09/05/2012
• Issued: 05/01/2018
• Est. Priority Date: 09/06/2011
• Status: Active Grant

• Current Assignee: Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Original Assignee: Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Inventors: Nguyen, Lan, Foley, John, Prendergast, Jonathan, Case, Brian
• Primary Examiner(s): Satanovsky, Alexander
• Assistant Examiner(s): CORDERO, LINA M
• Application Number:
  US13/604,133
• Publication Number:
  US 20130233394A1
• Time in Patent Office: 2,064 Days
• Field of Search: 222 58, 137 2
• CPC Class Codes: A61J 1/20 Arrangements for transferring or mixing fluids, e.g. from vial to syringe
• CPC Class Codes: A61M 1/342 Adding solutions to the blood, e.g. substitution solutions for preventing coagulation A61M1/3672
• CPC Class Codes: A61M 1/3496 Plasmapheresis; Leucopheresis; Lymphopheresis A61M1/3472 takes precedence
• CPC Class Codes: A61M 2205/3393 by weighing the reservoir
• CPC Class Codes: A61M 2205/505 Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: Y10T 137/0324 With control of flow by a condition or characteristic of a fluid
• CPC Class Codes: Y10T 137/27 Liquid level responsive
• CPC Class Codes: Y10T 137/7313 Control of outflow from tank

Abstract

Systems and methods for determining when a fluid supply container of a blood processing apparatus becomes empty. The system uses a scale to monitor and detect when a fluid supply container is empty based on the rate of change of the container weight and whether the container weight is below a pre-established threshold, and a controller receives a signal from the scale and controls the operation of a pump to stop pumping when the fluid supply container is empty.

Claims

1. A blood processing apparatus configured to process blood in a disposable fluid flow system that may be associated therewith, the disposable fluid flow system having at least a first fluid supply container and a second fluid supply container, each containing a fluid to be reinfused into a patient, the apparatus comprising:

a first scale for measuring a weight of the first fluid supply container and providing a first output signal indicative of the measured weight of the first fluid supply container;

a second scale for measuring a weight of the second fluid supply container and providing a second output signal indicative of the measured weight of the second fluid supply container;

a pump for pumping fluid from the first and second fluid supply containers for reinfusion into the patient;

a first valve in fluid communication between the first fluid supply container and the pump, the first valve normally in an open condition;

a second valve in fluid communication between the second fluid supply container and the pump, the second valve normally in a closed condition;

a controller configured to receive the first output signal from the first scale, to determine a rate of change in weight of the first fluid supply container, to determine that the first fluid supply container is empty when the rate of change becoming substantially zero occurs simultaneously with the first fluid supply container weight being below a first pre-established threshold that is greater than a weight of the first fluid supply container when empty;

to cause the pump to cease pumping upon determining that the first fluid supply container is empty, to cause the second valve to move to an open condition and to cause the first valve to move to a closed condition, to activate the pump to begin pumping fluid from the second fluid supply container, and to provide notification when a ratio of the rate of change in weight to a volume pumped is less than a predetermined value for the second fluid supply container occurs simultaneously with less than a predetermined time elapsing after the pump begins pumping fluid from the second fluid supply container.

2. The blood processing apparatus of claim 1 wherein the pump operates in a first direction when pumping fluid from the first fluid supply container and the pump operates in a second direction when pumping fluid from the second fluid supply container.

3. The blood processing apparatus of claim 1 wherein the controller is configured to receive the second output signal from the second scale, to determine the rate of change in weight of the second fluid supply container, and to determine that the second fluid supply container is empty when the rate of change becoming substantially zero occurs simultaneously with the second fluid supply container weight being below a second pre-established threshold that is greater than the weight of the second fluid supply container when empty.

4. The blood processing apparatus of claim 1 wherein the first scale measures the weight of the first fluid supply container over pump-unit intervals and the controller is configured to compare a weight change measured by the first scale for each pump-unit interval to a volume pumped during the pump-unit intervals.

5. The blood processing apparatus of claim 4 wherein the controller is configured to indicate the first fluid supply container is empty if the ratio of the weight change to the volume pumped is less than a predetermined value for two consecutive pump-unit intervals.

6. The blood processing apparatus of claim 1 wherein the fixed, constant amount by which the controller increases the accumulated volume corresponds to a first volume of a first tubing segment leading from the first fluid supply container to the first valve or to a second volume of a second tubing segment leading from the second fluid supply container to the second valve.

7. The blood processing apparatus of claim 1 wherein the controller is further configured to track an accumulated volume of fluid pumped from the first fluid supply container based on the change of weight of the first fluid supply container, and to increase the accumulated volume by a fixed, constant amount for each time the pumping switches between the first and second fluid supply containers.

8. A blood processing apparatus configured to process blood in a selected one of a plurality of differently-configured disposable fluid flow systems that may be associated therewith, each fluid flow system having at least a first fluid supply container with a first tubing segment connected thereto and a second fluid supply container with a second tubing segment connected thereto, the apparatus comprising:

a first scale for measuring a weight of the first fluid supply container of the selected one of the plurality of differently-configured disposable fluid flow systems and providing a first output signal indicative of the measured weight of the first fluid supply container;

a second scale for measuring a weight of the second fluid supply container of the selected one of the plurality of differently-configured disposable fluid flow systems and providing a second output signal indicative of the measured weight of the second fluid supply container;

a pump for pumping fluid from the first fluid supply container;

a first valve in fluid communication between the first fluid supply container and the pump, the first valve normally in an open condition;

the first tubing segment connected to the first supply container leading to the first valve, the first scale being configured so as not to measure the weight of the first tubing segment when measuring the weight of the first fluid supply container;

a second valve in fluid communication between the second fluid supply container and the pump, the second valve normally in a closed condition;

the second tubing segment connected to the second supply container leading to the second valve, the second scale being configured so as not to measure the weight of the second tubing segment when measuring the weight of the second fluid supply container;

a controller configured to receive the first output signal from the first scale, and to determine a rate of change in weight of the first fluid supply container,

the controller further configured to determine that the first fluid supply container is empty when a ratio of the rate of change in weight of the first fluid supply container to a rate of fluid flow from the pump being less than a predetermined value occurs simultaneously with the weight of the first fluid supply container being less than a first pre-established threshold;

to cause the pump to cease pumping upon determining that the first fluid supply container is empty;

to cause the second valve to move to an open condition and to cause the first valve to move to a closed condition;

to then activate the pump to begin pumping fluid from the second fluid supply container;

to provide notification when the ratio of the rate of change in weight to a volume pumped is less than a predetermined value for the second fluid supply container occurs simultaneously with less than a predetermined time elapsing after the pump begins pumping fluid from the second fluid supply container;

to track an accumulated volume of fluid pumped from the first fluid supply container based on the change of weight of the first fluid supply container; and

to increase the accumulated volume by a fixed, constant amount specific to the selected one of the plurality of differently-configured disposable fluid flow systems associated with the blood processing apparatus corresponding to a first volume of the first tubing segment leading to the first valve or to a second volume of the second tubing segment leading to the second valve for each time the pumping switches between the first and second fluid supply containers.

9. A method of processing blood in a disposable fluid flow system associated with a blood processing apparatus, the method comprising:

providing a first fluid supply container of the disposable fluid flow system adapted to be in communication with a patient when a first valve is in an open condition;

providing a second fluid supply container of the disposable fluid flow systems adapted to be in communication with the patient when a second valve is in an open condition;

monitoring a weight of the first fluid supply container while it is being emptied by a pump that is pumping fluid from the first fluid supply container into the patient;

establishing a first threshold weight for the first fluid supply container that is greater than a weight of the first fluid supply container when empty;

determining a rate of change of the weight of the first fluid supply container;

determining when the rate of change of the weight of the first fluid supply container becomes substantially zero simultaneously with the weight of the first fluid supply container being less than the first threshold weight;

stopping the operation of the pump and moving the first valve to a closed condition when the rate of change of the weight of the first fluid supply container is determined to be substantially zero and the weight of the first fluid supply container is less than the first threshold weight and moving the second valve to an open condition; and

providing notification when a ratio of the rate of change of the weight to a volume pumped is less than a predetermined value for the second fluid supply container occurs simultaneously with less than a predetermined time elapsing after the pump begins pumping fluid from the second fluid supply container.

10. The method of claim 9 further comprising:

measuring the weight of the second fluid supply container while it is being emptied by the pump that is pumping fluid from the second fluid supply container into the patient;

establishing a second threshold weight for the second fluid supply container that is greater than a weight of the second fluid supply container when empty;

determining a rate of change of the weight of the second fluid supply container;

determining when the rate of change of the weight of the second fluid supply container becomes substantially zero simultaneously with the weight of the second fluid supply container being less than the second threshold weight; and

stopping the operation of the pump when the rate of change of the weight of the second fluid supply container is determined to be substantially zero and the weight of the second fluid supply container is less than the second threshold weight.

11. The method of claim 9 further comprising tracking an accumulated volume of fluid pumped from the first and second fluid supply containers based on the change of weight of the fluid supply containers and increasing the accumulated volume by a fixed, constant amount corresponding to a first volume of a first tubing segment leading from the first fluid supply container to the first valve or to a second volume of a second tubing segment leading from the second fluid supply container to the second valve for each time the pumping switches between the first and second fluid supply containers.