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Methods for increasing immune responses using agents that directly bind to and activate IRE-1

  • US 9,956,236 B2
  • Filed: 02/07/2012
  • Issued: 05/01/2018
  • Est. Priority Date: 02/07/2011
  • Status: Active Grant
First Claim
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1. A method for increasing activation of immune cells in a subject, comprising administering at least one toll-like receptor (TLR) agonist and a human immunodeficiency virus (HIV) protease inhibitor that activates IRE-1 in the subject thereby increasing activation of immune cells in the subject, wherein the toll-like receptor (TLR) agonist stimulates TLR4;

  • and contacting the immune cells with an antigen to which an immune response is desired.

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