Application of American Ginseng to enhance neurocognitive function

• US 9,956,241 B2
• Filed: 02/27/2015
• Issued: 05/01/2018
• Est. Priority Date: 05/04/2009
• Status: Active Grant

• Current Assignee: Naturex SA (Givaudan SA)
• Original Assignee: Naturex SA (Givaudan SA)
• Inventors: Scholey, Andrew, Ibarra, Alvin, He, Kan, Roller, Marc, Dikansky, Jacques
• Primary Examiner(s): HOFFMAN, SUSAN COE
• Application Number:
  US14/633,168
• Publication Number:
  US 20150306119A1
• Time in Patent Office: 1,159 Days
• Field of Search: None
• CPC Class Codes: A61K 31/704 attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin digitoxin A61K31/7048
• CPC Class Codes: A61K 36/258 Panax (ginseng)

Abstract

Disclosed are methods of enhancing neurocognitive function by administering of American Ginseng. Preferred dosages in the range of 5 to 50 mg total ginsenosides enhance cognitive function—including, improvement of working memory (WM) performance, attentional performance (e.g., Choice Reaction Time accuracy), and calmness.

Claims

1. A method of enhancing cognitive performance in working memory of a human subject in need thereof, the method comprising administering to said human subject a composition comprising American ginseng extract and a carrier, in an effective amount to enhance the cognitive performance, wherein said American ginseng extract comprises, by weight of said American ginseng extract, about 0.2% of ginsenoside Rb2 and about 5.0% of ginsenoside Rb1.

2. The method of claim 1, wherein said American ginseng extract further comprises, by weight of said American ginseng extract, about 0.2% of ginsenoside Rg1, about 2.0% of ginsenoside Re, about 2.0% of ginsenoside Rc, and about 1.4% of ginsenoside Rd.

3. The method of claim 2, wherein said American ginseng extract is free of ginsenoside Rf.

4. The method of claim 2, wherein said effective amount comprises about 23.30 mg of said ginsenoside Rb2, said ginsenoside Rg1, said ginsenoside Re, said ginsenoside Rb1, said ginsenoside Rc, and said ginsenoside Rd in total.

5. The method of claim 1, wherein said effective amount is between 100 and 400 mg.

6. The method of claim 1, wherein said carrier is maltodextrin.

7. The method of claim 1, wherein the method further comprises assessing said cognitive performance by administering a test to said human subject, said test is Corsi block task, Numeric Working Memory test, Alphabetic Working Memory test, or a mixture thereof.

8. The method of claim 7, wherein said human subject is administered said composition between 1 and 6 hours prior to the step of assessing said cognitive performance.