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Post-processing of a medical device to control morphology and mechanical properties

  • US 9,956,385 B2
  • Filed: 06/25/2013
  • Issued: 05/01/2018
  • Est. Priority Date: 06/28/2012
  • Status: Active Grant
First Claim
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1. A method of forming a coated medical device comprising:

  • applying a coating to an outer surface of a medical device, the coating including a therapeutic agent dispersed in a matrix of a polymer or oligomer excipient;

    post-processing the medical device by immersion in a solvent or solution, thereby selectively removing a substantial portion of the polymer or oligomer excipient from the matrix in which the therapeutic agent is dispersed; and

    sterilizing the post-processed medical device,wherein the coating comprises less than 50% by weight of the therapeutic agent prior to post-processing, and the coating comprises greater than 50% by weight of the therapeutic agent after post-processing.

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