Wireless interstitial fluid pressure sensor

• US 9,962,084 B2
• Filed: 06/16/2014
• Issued: 05/08/2018
• Est. Priority Date: 06/15/2013
• Status: Active Grant

• Current Assignee: Purdue Research Foundation (The Trustees of Purdue University (d/b/a Purdue University))
• Original Assignee: Purdue Research Foundation (The Trustees of Purdue University (d/b/a Purdue University))
• Inventors: Ziaie, Babak, Brown, Marcus Anthony, Maleki-Jafarabadi, Teimour, Song, Seung Hyun
• Primary Examiner(s): Stout, Michael C
• Application Number:
  US14/305,907
• Publication Number:
  US 20140371624A1
• Time in Patent Office: 1,422 Days
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/036 by means introduced into body tracts A61B5/032 and A61B5/035 take precedence

Abstract

An implantable pressure sensor arrangement is disclosed. The arrangement includes a substrate, a coil positioned on the substrate, a flexible membrane positioned proximate to the coil and configured to be moveable with respect to the coil, thereby forming a fluid chamber, fluidly sealed from outside of the implantable pressure sensor arrangement, a porous membrane positioned on the flexible membrane and configured to transfer pressure from outside of the implantable pressure sensor arrangement onto the flexible membrane wherein a differential pressure is generated on the two sides of the flexible membrane thereby causing the flexible membrane to deflect towards and away from the coil, and an electrode coupled to the flexible membrane.

Claims

1. A system for a wireless implantable pressure sensor, comprising:

an energization/interrogation arrangement configured to generate an energization signal and to receive and interrogate a response signal; and

an implantable pressure sensor arrangement wirelessly coupled to the energization/interrogation arrangement, the implantable pressure sensor arrangement including;

a substrate,

a coil disposed on the substrate,

a flexible membrane disposed proximate to the coil and configured to be moveable with respect to the coil, thereby forming a fluid chamber fluidly sealed from outside of the implantable pressure sensor arrangement,

a porous membrane disposed on the flexible membrane and configured to transfer pressure from outside of the implantable pressure sensor arrangement onto the flexible membrane wherein a differential pressure is generated on the two sides of the flexible membrane, wherein the flexible membrane is configured to deflect toward or away from the coil, the porous membrane comprising a plurality of perforations, and wherein the porous membrane is configured to transfer fluid through each perforation of the plurality of perforations, wherein an entirety of the porous membrane is over the flexible membrane, and

an electrode coupled to the flexible membrane,

the movement of the flexible membrane with respect to the coil configured to change resonant frequency of the implantable pressure sensor arrangement, the change readable by the energization/interrogation arrangement as a function of pressure existing outside of the implantable pressure sensor arrangement.

2. The wireless implantable pressure sensor system of claim 1, the electrode is fixed to the flexible membrane.

3. The wireless implantable pressure sensor system of claim 2, the electrode is embedded in the flexible membrane.

4. The wireless implantable pressure sensor system of claim 1, the electrode is ferromagnetic.

5. The wireless implantable pressure sensor system of claim 4, the electrode is a nickel-plated copper plate.

6. The wireless implantable pressure sensor system of claim 1, the coil is copper.

7. The wireless implantable pressure sensor system of claim 1, the substrate is Polydimethylsiloxane.

8. The wireless implantable pressure sensor system of claim 1, the porous membrane is poly(ethylene terephthalate).

9. The wireless implantable pressure sensor system of claim 1, the fluid chamber includes compressible fluid.

10. The wireless implantable pressure sensor system of claim 9, the fluid chamber includes air.

11. The wireless implantable pressure sensor system of claim 1, the system configured to sense pressure in vivo.

12. The wireless implantable pressure sensor system of claim 11, the system configured to sense pressure inside a tumor.

13. An implantable pressure sensor arrangement, comprising:

a substrate;

a coil disposed on the substrate;

a flexible membrane directly over the coil and configured to be moveable with respect to the coil, thereby forming a fluid chamber, fluidly sealed from outside of the implantable pressure sensor arrangement;

a porous membrane disposed on the flexible membrane and configured to transfer pressure from outside of the implantable pressure sensor arrangement onto the flexible membrane wherein a differential pressure is generated on the two sides of the flexible membrane thereby causing the flexible membrane to deflect towards and away from the coil wherein an entirety of the porous membrane is over the flexible membrane; and

an electrode coupled to the flexible membrane,

the movement of the flexible membrane with respect to the coil configured to change resonant frequency of the implantable pressure sensor arrangement, the change readable by an energization/interrogation arrangement as a function of pressure existing outside of the implantable pressure sensor arrangement.

14. The implantable pressure sensor arrangement of claim 13, the electrode is fixed to the flexible membrane.

15. The implantable pressure sensor arrangement of claim 14, the electrode is embedded in the flexible membrane.

16. The implantable pressure sensor arrangement of claim 13, the electrode is ferromagnetic.

17. The implantable pressure sensor arrangement of claim 16, the electrode is a nickel-plated copper plate.

18. The implantable pressure sensor arrangement of claim 13, the coil is copper.