Absorbent substrates for harvesting skin grafts

• US 9,962,254 B2
• Filed: 03/14/2014
• Issued: 05/08/2018
• Est. Priority Date: 03/14/2013
• Status: Active Grant

• Current Assignee: Solventum Intellectual Properties Company (Solventum Corp.)
• Original Assignee: KCI Licensing Incorporated (3M Company)
• Inventors: Locke, Christopher Brian, Robinson, Timothy Mark, Harper, John R.
• Primary Examiner(s): Prone, Christopher D
• Assistant Examiner(s): Diop, Rokhaya
• Application Number:
  US14/211,026
• Publication Number:
  US 20140277454A1
• Time in Patent Office: 1,516 Days
• CPC Class Codes: A61B 17/322 Skin grafting apparatus
• CPC Class Codes: A61B 2017/3225 with processing of harvested tissue
• CPC Class Codes: A61F 13/00051 Accessories for dressings
• CPC Class Codes: A61F 13/0206 with absorbent fibrous layers, e.g. woven or non-woven absorbent pads or island dressings
• CPC Class Codes: A61F 13/0213 the fluid retention member being a layer of hydrocolloid, gel forming material
• CPC Class Codes: A61F 13/0223 characterized by parametric properties of the fluid retention layer, e.g. absorbency, wicking capacity, liquid distribution
• CPC Class Codes: A61F 13/0226 characterised by the support layer
• CPC Class Codes: A61F 13/025 having a special distribution arrangement of the adhesive
• CPC Class Codes: A61F 13/0259 characterised by the release liner covering the skin adhering layer
• CPC Class Codes: A61F 2/0095 Packages or dispensers for prostheses or other implants for intraocular lenses A61F2/1691; for dental surgery A61C19/02
• CPC Class Codes: A61F 2/105 Skin implants, e.g. artificial skin

Abstract

Methods and devices for management of fluids during skin graft transplantation are disclosed. In one aspect of the invention, absorbent substrates for transplanting skin grafts are disclosed having a surface adapted to contact at least one excised skin graft and engage said graft for removal from a donor site; a sealing member at least partially surrounding an absorbent material disposed within the enclosure; wherein at least a portion of the skin-contacting surface is porous and in fluid communication with the absorbent layer to capture fluids.

Claims

1. An absorbent substrate for transplanting a skin graft, comprising:

a base layer having a plurality of pores and having at least one adhesive site adapted to contact at least one excised skin graft and capture said graft for removal from a donor site;

a sealing member peripherally joined to the base layer and defining an enclosure therebetween;

an absorbent material disposed within the enclosure; and

at least a first wicking layer and a second wicking layer disposed in the enclosure between the base layer and the absorbent material, said first wicking layer having a grain structure adapted to transport fluid in a lateral direction along a surface thereof, the second wicking layer being disposed adjacent to the sealing member and the first and second wicking layers being joined together to form a seal that encloses the absorbent material;

wherein at least a portion of the base layer is in fluid communication with the absorbent material to capture fluids.

2. The substrate of claim 1, wherein the base layer is configured to be positioned in a chamber of a skin graft harvesting device.

3. The substrate of claim 2, wherein the base layer is configured to capture a plurality of skin grafts at the same time.

4. The substrate of claim 1, wherein the base layer comprises a biocompatible material.

5. The substrate of claim 4, wherein the biocompatible material, is selected from the group of silicones, silicone gels, soft silicones, hydrocolloids, hydrogels, polyurethanes, polyurethane gels, polyolefins, polyolefin gels, hydrogenated styrenic copolymers, hydrogenated styrenic copolymer gels, foamed gels and combinations thereof.

6. The substrate of claim 1, wherein the base layer comprises a silicone.

7. The substrate of claim 1, wherein the skin graft contacting portion of the base layer has an average thickness between about 500 microns (μ

m) and about 1000 microns (μ

m).

8. The substrate of claim 1, wherein the skin graft contacting portion of the base layer has a stiffness between about 5 Shore OO and about 80 Shore OO.

9. The substrate of claim 1, wherein the at least one adhesive site comprises a coating of an adhesive material on at least a portion of the base layer.

10. The substrate of claim 9, wherein the adhesive material comprises an acrylic adhesive.

11. The substrate of claim 1, wherein the at least one adhesive site comprises a pattern of adhesive sites.

12. The substrate of claim 1, wherein the at least one adhesive site comprises a plurality of adhesive sites printed on at least a portion of a skin-contacting surface of the base layer.

13. The substrate of claim 1, wherein the plurality of pores provides passageways for fluid transport from the recipient site to the absorbent material.

14. The substrate of claim 13, wherein the base layer comprises a foamed polymer.

15. The substrate of claim 13, wherein the base layer comprises a fluid permeable polymeric material.

16. The substrate of claim 13, wherein the base layer comprises a fibrous material.

17. The substrate of claim 16, wherein the fibrous material comprises a plurality of microfibers having an average diameter of about 0.1 micrometers to about 10 micrometers.

18. The substrate of claim 16, wherein the fibrous material comprises a plurality of nanofibers having an average diameter of about 1 nanometer to about 100 nanometers.

19. The substrate of claim 16, wherein the fibrous material comprises a plurality of nanofibers having an average diameter of about 20 nanometers to about 80 nanometers.

20. The substrate of claim 13, wherein the pores have an average cross-sectional dimension ranging from about 1 nanometer to about 1 millimeter.

21. The substrate of claim 13, wherein the pores have an average cross-sectional dimension ranging from about 1 nanometer to about 100 micrometers.

22. The substrate of claim 1, wherein the at least one adhesive site comprise a plurality of adhesive sites defining a plurality of skin graft capture sites and wherein the base layer further comprises a network of pores disposed between at least some of the capture sites.

23. The substrate of claim 22, wherein the pores are generally circular and have an average cross-sectional dimension ranging from about 1 nanometer to about 1 millimeter.

24. The substrate of claim 23, wherein the pores have an average cross-sectional dimension ranging from about 1 nanometer to about 100 micrometers.

25. The substrate of claim 1, wherein the substrate further comprises at least one wicking layer disposed in the enclosure and adapted to distribute fluid to the absorbent material.

26. The substrate of claim 1, wherein the second wicking layer has a grain structure adapted to wick fluid in a lateral direction along a surface of the second wicking layer.

27. The substrate of claim 26, wherein the absorbent material comprises a plurality of absorbent layers, and wherein the plurality of absorbent layers are positioned in fluid communication between the first wicking layer and the second wicking layer.

28. The substrate of claim 27, further comprising at least one intermediate wicking layer disposed in fluid communication between the absorbent layers.

29. The substrate of claim 1, wherein a peripheral portion of the first wicking layer is coupled to a peripheral portion of the second wicking layer providing a wicking layer enclosure surrounding the absorbent material between the first and the second wicking layer.

30. The substrate of claim 1, wherein the absorbent material comprises a hydrophilic material that is adapted to absorb fluid.

31. The substrate of claim 1, wherein the sealing member is liquid impermeable.

32. The substrate of claim 1, wherein the sealing member comprises polyurethane.

33. The substrate of claim 1, further comprising a port for coupling to a reduced pressure source to extract accumulated fluids from the substrate.

34. The substrate of claim 33, wherein the port further comprises a valve.

35. The substrate of claim 33, wherein the port further comprises a conduit providing fluid communication between the absorbent material or at least one wicking layer within the enclosure and an external fluid receptacle.

36. The substrate of claim 1, wherein the substrate comprises at least one removable backing for handling the substrate prior to positioning in a skin graft harvester.

37. The substrate of claim 1, wherein the substrate comprises at least one removable backing for handling the substrate prior to positioning at a recipient site.

38. The substrate of claim 1, wherein the substrate comprises at least a first removable backing associated with the base layer for handling the substrate prior to positioning in a skin graft harvester and a second removable backing for handling the substrate and an associated skin graft prior to positioning at a recipient site.

39. The substrate of claim 1, wherein the base layer and the absorbent material are formed as a unitary structure.

40. An absorbent substrate for transplanting a skin graft, comprising:

a base layer having a plurality of pores and having at least one adhesive site adapted to contact at least one excised skin graft and capture said graft for removal from a donor site, said pores having an average width in a range of about 1 nanometer to about 10 micrometers;

a sealing member peripherally joined to the base layer and defining an enclosure therebetween;

an absorbent material disposed within the enclosure; and

at least a first wicking layer and a second wicking layer disposed in the enclosure between the base layer and the absorbent material, the second wicking layer being disposed adjacent to the sealing member and the first and second wicking layers being joined together to form a seal that encloses the absorbent material;

wherein at least a portion of the base layer is in fluid communication with the absorbent material to capture fluids.

41. The substrate of claim 40, wherein said base layer comprises a biocompatible material.

42. The substrate of claim 41, wherein said biocompatible material is selected from the group of silicones, silicone gels, soft silicones, hydrocolloids, hydrogels, polyurethanes, polyurethane gels, polyolefins, polyolefin gels, hydrogenated styrenic copolymers, hydrogenated styrenic copolymer gels, foamed gels and combinations thereof.

43. The substrate of claim 40, wherein the skin graft contacting portion of the base layer has an average thickness between about 500 microns and about 1000 microns.

44. The substrate of claim 40, wherein the skin graft contacting portion of the base layer has a stiffness between about 5 Shore OO and about 80 Shore OO.