Stabilized assembled nanostructures for delivery of encapsulated agents
First Claim
1. A self-assembled organo or hydrogel composition comprisingone or more low molecular weight amphiphilic gelators having a molecular weight of less than 2,500 Da andone or more aggregation decreasing agents selected from the group consisting of sterols, phospholipids, and a combination thereof,wherein the gelators and the aggregation decreasing agents co-assemble into hydrogel or organo-gel comprising nanostructures,wherein the aggregation decreasing agent is at least 15 mole % of the composition.
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Abstract
A non-covalently assembled hydrogel or organo-gel composition with serum stability is described. Low molecular weight (<2,500 Da), generally regarded as safe (GRAS), materials assemble in the presence of a stabilizing agent at an appropriate molar percentage, forming hydrogel or organo-gel with nanostructures that resist disassembly or destabilization in serum for an extended period of time. The composition is used to deliver one or more therapeutic, prophylactic, or diagnostic agents, allowing for controlled release in response to biological stimuli such as enzymes and a greatly improved dosing efficacy.
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30 Claims
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1. A self-assembled organo or hydrogel composition comprising
one or more low molecular weight amphiphilic gelators having a molecular weight of less than 2,500 Da and one or more aggregation decreasing agents selected from the group consisting of sterols, phospholipids, and a combination thereof, wherein the gelators and the aggregation decreasing agents co-assemble into hydrogel or organo-gel comprising nanostructures, wherein the aggregation decreasing agent is at least 15 mole % of the composition.
Specification