Integrated sensor arrays for biological and chemical analysis
First Claim
Patent Images
1. An apparatus comprising:
- a chemical field effect transistor array in a circuit-supporting substrate, such transistor array having disposed on its surface an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid, wherein such transistor array has a pitch of 10 μ
m or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region, the at least one chemical field effect transistor generating the at least one output signal at a circuit node at a first time interval, a first switch between the chemical field effect transistor and the circuit node to couple a terminal of the chemical field effect transistor to the circuit node in response to a select signal;
a reference circuit including a second switch directly connected to the circuit node for coupling a reference signal to the circuit node in response to a timing signal during a second time interval; and
a sampling circuit producing an output signal as a function of a first sample obtained during the first time interval and a second sample obtained during the second time interval.
1 Assignment
0 Petitions
Accused Products
Abstract
An apparatus comprising a chemical field effect transistor array in a circuit-supporting substrate is disclosed. The transistor array has disposed on its surface an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid. The transistor array has a pitch of 10 μm or less and a sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region.
-
Citations
11 Claims
-
1. An apparatus comprising:
-
a chemical field effect transistor array in a circuit-supporting substrate, such transistor array having disposed on its surface an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid, wherein such transistor array has a pitch of 10 μ
m or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region, the at least one chemical field effect transistor generating the at least one output signal at a circuit node at a first time interval, a first switch between the chemical field effect transistor and the circuit node to couple a terminal of the chemical field effect transistor to the circuit node in response to a select signal;a reference circuit including a second switch directly connected to the circuit node for coupling a reference signal to the circuit node in response to a timing signal during a second time interval; and a sampling circuit producing an output signal as a function of a first sample obtained during the first time interval and a second sample obtained during the second time interval. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
Specification