Detection of an immune response
First Claim
1. A method of treating an allergic disorder in a mammalian subject, comprising administering an immunotherapy treatment to a subject having a significant cell frequency of CD4+ T cells that are CRTH2 positive and CD161 positive,said method further comprising detecting a cell frequency of CD4+ T cells that are CRTH2 positive and CD161 positive in a biological sample of the subject,wherein the detecting is carried out by a method comprising:
- contacting the biological sample of the subject with antibodies, said antibodies comprising anti-CD4, anti-CRTH2 and anti-CD161, and then detecting the antibodies to thereby detect the cell frequency of CD4+ T cells that are CRTH2 positive and CD161 positive in the biological sample.
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Abstract
Provided herein are methods of detecting and/or monitoring the presence or severity of an immune disorder in a subject, including detecting a frequency of a Th2a subset of CD4+ T cells in a biological sample of the subject. In some embodiments, the detecting includes: (a) detecting a frequency of CD4+ T cells in a biological sample of said subject; (b) detecting a frequency of a Th2a subset of the CD4+ T cells in the biological sample; and (c) comparing the frequency of the Th2a subset with the frequency of the CD4+ T cells.
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Citations
17 Claims
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1. A method of treating an allergic disorder in a mammalian subject, comprising administering an immunotherapy treatment to a subject having a significant cell frequency of CD4+ T cells that are CRTH2 positive and CD161 positive,
said method further comprising detecting a cell frequency of CD4+ T cells that are CRTH2 positive and CD161 positive in a biological sample of the subject, wherein the detecting is carried out by a method comprising: - contacting the biological sample of the subject with antibodies, said antibodies comprising anti-CD4, anti-CRTH2 and anti-CD161, and then detecting the antibodies to thereby detect the cell frequency of CD4+ T cells that are CRTH2 positive and CD161 positive in the biological sample.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
Specification