Imaging fluorescence or luminescence lifetime
First Claim
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1. A device for use in fluorescence or luminescence lifetime imaging, the device comprising:
- a chip comprising;
an imaging region comprising a photodetector for receiving a first optical signal corresponding to excitation light from a light source, and a second optical signal corresponding to emitted fluorescence or luminescence from a sample; and
a time-to-digital converter for providing digital phase output based on the first and second optical signals, wherein the digital phase output corresponds to a temporal offset between waveforms corresponding to the excitation light and the emitted fluorescence or luminescence from the sample.
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Abstract
Devices for use in fluorescence or luminescence lifetime imaging include a chip featuring an imaging region that includes a photodetector for receiving optical signals, and a time-to-digital converter for providing digital phase output based on the received optical signals.
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Citations
21 Claims
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1. A device for use in fluorescence or luminescence lifetime imaging, the device comprising:
a chip comprising; an imaging region comprising a photodetector for receiving a first optical signal corresponding to excitation light from a light source, and a second optical signal corresponding to emitted fluorescence or luminescence from a sample; and a time-to-digital converter for providing digital phase output based on the first and second optical signals, wherein the digital phase output corresponds to a temporal offset between waveforms corresponding to the excitation light and the emitted fluorescence or luminescence from the sample. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A microscope comprising:
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a lens; and an integrated complementary metal-oxide semiconductor (CMOS) chip comprising; an imaging region comprising a photodetector for receiving a first optical signal corresponding to excitation light from a light source, and a second optical signal corresponding to emitted fluorescence or luminescence from a sample that passes through the lens; and a time-to-digital converter for providing digital phase output based on the first and second optical signals, wherein the digital phase output corresponds to a temporal offset between waveforms corresponding to the excitation light and the emitted fluorescence or luminescence from the sample. - View Dependent Claims (8, 9, 10, 11, 12, 13)
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14. A scanner for use in detecting skin cancer, the scanner comprising:
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an integrated complementary metal-oxide semiconductor (CMOS) chip comprising; an imaging region comprising a photodetector for receiving a first optical signal corresponding to excitation light from a light source, and a second optical signal corresponding to emitted fluorescence or luminescence from a sample; and a time-to-digital converter for providing digital phase output based on the first and second optical signals, wherein the digital phase output corresponds to a temporal offset between waveforms corresponding to the excitation light and the emitted fluorescence or luminescence from the sample; and a display for displaying the digital phase output from the integrated CMOS chip. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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Specification