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Anti-interferent barrier layers for non-invasive transdermal sampling and analysis device

  • US 9,968,284 B2
  • Filed: 11/29/2012
  • Issued: 05/15/2018
  • Est. Priority Date: 12/02/2011
  • Status: Active Grant
First Claim
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1. A transdermal sampling and analysis device comprising:

  • a substrate having a first side;

    at least one disruptor mounted on the first side of the substrate, wherein the at least one disruptor is configured to generate a localized heat capable of altering permeability characteristics of a stratum corneum layer of skin of an organism;

    a reservoir configured to collect and contain a biological sample; and

    a biological sensing element comprising;

    a sensing chamber forming a circular shape around a periphery of the reservoir;

    at least two sensing electrodes configured to determine levels of an analyte in the biological sample; and

    circular sensing channels configured to guide the biological sample through the sensing chamber, wherein the biological sample is directed over an entire surface of each of the at least two sensing electrodes;

    wherein;

    a surface of at least one of the sensing electrodes is coated with a sensing layer having a first charge type; and

    the sensing layer is covered with an anti-interferent barrier layer having at least a second charge type, wherein the first charge type is an opposite charge type from the second charge type.

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