Anti-interferent barrier layers for non-invasive transdermal sampling and analysis device
First Claim
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1. A transdermal sampling and analysis device comprising:
- a substrate having a first side;
at least one disruptor mounted on the first side of the substrate, wherein the at least one disruptor is configured to generate a localized heat capable of altering permeability characteristics of a stratum corneum layer of skin of an organism;
a reservoir configured to collect and contain a biological sample; and
a biological sensing element comprising;
a sensing chamber forming a circular shape around a periphery of the reservoir;
at least two sensing electrodes configured to determine levels of an analyte in the biological sample; and
circular sensing channels configured to guide the biological sample through the sensing chamber, wherein the biological sample is directed over an entire surface of each of the at least two sensing electrodes;
wherein;
a surface of at least one of the sensing electrodes is coated with a sensing layer having a first charge type; and
the sensing layer is covered with an anti-interferent barrier layer having at least a second charge type, wherein the first charge type is an opposite charge type from the second charge type.
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Abstract
A system and methods are provided for reducing electrochemical interference in a transdermal sampling and analysis device. A one-step transdermal glucose biosensor may calculate glucose concentrations that are artificially high compared to traditional home blood glucose sensors due to interference, which may be mitigated by forming an anti-interferent barrier layer over a sensing element. The anti-interferent barrier layer may be formed over a sensing layer and may possess a charge type which repels interferent molecules having the same charge type from interacting with the sensing layer disposed below the anti-interferent barrier layer.
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Citations
19 Claims
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1. A transdermal sampling and analysis device comprising:
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a substrate having a first side; at least one disruptor mounted on the first side of the substrate, wherein the at least one disruptor is configured to generate a localized heat capable of altering permeability characteristics of a stratum corneum layer of skin of an organism; a reservoir configured to collect and contain a biological sample; and a biological sensing element comprising; a sensing chamber forming a circular shape around a periphery of the reservoir; at least two sensing electrodes configured to determine levels of an analyte in the biological sample; and circular sensing channels configured to guide the biological sample through the sensing chamber, wherein the biological sample is directed over an entire surface of each of the at least two sensing electrodes; wherein; a surface of at least one of the sensing electrodes is coated with a sensing layer having a first charge type; and the sensing layer is covered with an anti-interferent barrier layer having at least a second charge type, wherein the first charge type is an opposite charge type from the second charge type. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of preventing interference from a charged biological reducing species in a transdermal biosensor device, comprising:
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creating a reservoir configured to collect and contain a biological sample containing the biological reducing species; creating a sensing chamber forming a circular shape around a periphery of the reservoir; creating a solid state sensor wherein an enzyme and an electron mediator are immobilized by a polymer to form a sensing layer, wherein the polymer is anchored to a sensing electrode; applying an anti-interferent barrier layer atop the sensing layer, wherein charge type repulsion between the anti-interferent barrier layer and the charged biological reducing species prevents interaction between the charged biological reducing species and the electron mediator; and creating circular channels configured to guide the biological sample through the sensing chamber, wherein the biological sample is directed over an entire surface of the solid state sensor. - View Dependent Claims (16, 17, 18, 19)
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Specification