Systems and methods for predicting seizures

• US 9,968,288 B2
• Filed: 03/26/2015
• Issued: 05/15/2018
• Est. Priority Date: 03/26/2014
• Status: Active Grant

• Current Assignee: Eco-Fusion
• Original Assignee: Eco-Fusion
• Inventors: Fuerst, Oren
• Primary Examiner(s): MALAMUD, DEBORAH LESLIE
• Application Number:
  US14/670,169
• Publication Number:
  US 20150272494A1
• Time in Patent Office: 1,146 Days
• CPC Class Codes: A61B 5/02055 Simultaneously evaluating both cardiovascular condition and temperature
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/0533 Measuring galvanic skin response
• CPC Class Codes: A61B 5/1101 Detecting tremor
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/681 Wristwatch-type devices
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B
• CPC Class Codes: A61B 5/7465 Arrangements for interactive communication between patient and care services, e.g. by using a telephone network telemetry of measured physiological signal A61B5/0002
• CPC Class Codes: A61M 21/02 for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia for massage A61H; electrotherapy A61N, e.g. applying alternating or intermittent electric currents for producing anaesthesia A61N1/36021
• CPC Class Codes: A61M 2205/054 with electrotherapy
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/37258 Alerting the patient
• CPC Class Codes: A61N 1/37282 characterised by communication with experts in remote locations using a network
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

The present invention provides for a computer system including at least one server having software stored on a non-transient computer readable medium; where, upon execution of the software, the at least one server is at least configured to: i) receiving physiological data representative of a first physiological measurement of at least one physiological characteristic of an epileptic user; ii) receiving physiological data representative of a second physiological measurement of at least one physiological characteristic of the epileptic user; iii) comparing the first physiological measurement of the epileptic user to the second physiological measurement of the epileptic user; iv) based on the comparing, determining that a difference between the first physiological measurement of the epileptic user and the second physiological measurement is: a) higher than a predetermined threshold value, or b) smaller than the predetermined threshold value; and v) generating at least one alert; vi) transmitting the at least one alert.

Claims

1. A computer system, comprising:

a) at least one wearable garment, comprising a plurality of non-invasive sensors;

i) wherein the plurality of non-invasive sensors are configured to continuously acquire, in real-time, a plurality of biosignals from a person wearing the at least one wearable garment;

ii) wherein the plurality of biosignals are representative of heart rate variability (HRV), electrodermal activity (EDA), and motor movement;

iii) wherein the at least one wearable garment is configured to wirelessly transmit the plurality of biosignals to at least one portable computing device associated with the person wearing the at least one wearable garment;

b) the at least one portable computing device having software stored on a non-transient computer readable medium;

wherein, upon execution of the software, the at least one portable computing device is at least configured to;

i) receiving, in real-time, a current set of the plurality of biosignals which are representative of a current value of at least one power spectral component of the heart rate variability (current HRV value), a current value of the electrodermal activity (current EDA value), and current motor movement of the person;

ii) dynamically calculating, in real-time, based on the current set of the plurality of biosignals, the current HRV value and the current EDA value;

iii) dynamically determining, in real-time, based on the current set of the plurality of biosignals, the current motor movement of the person;

iv) dynamically comparing, in real-time,

1) the current HRV value to at least-a population historical HRV value of a population of people, wherein each person of the population of people has at least one characteristic associated with at least one of a current psychological condition of the person and a current physiological condition of the person and wherein the at least one characteristic of the current physiological condition of the person is dependent on a food intake of the person;

2) the current EDA value to at least a population historical EDA value of the population of people; and

3) the current motor movement of the person to a historical motor movement of the person at the particular time period;

v) based on the comparing, dynamically determining, in real-time, a presence of at least one health-related condition;

vi) dynamically generating, in real-time, at least one alert when the presence of the at least one health-related condition has been determined; and

vii) at least one of;

1) dynamically appraising, via the at least one portable computing device, the person about the at least one alert, and

2) dynamically and wirelessly transmitting, in real-time, the at least one alert to at least one of;

a first electronic device associated with the at least one family member, a second electronic device associated with at least one medical practitioner, or any combination thereof.

2. The computer system of claim 1, wherein the at least one portable computing device is further configured to dynamically transmitting, in real-time, the at least one alert to a third electronic device;

and therein the third electronic device is configured to reside in the at least one wearable garment.

3. The computer system of claim 1, wherein the first electronic device and the second electronic device are portable electronic devices.

4. The computer system of claim 1, wherein the dynamically appraising, via the at least one portable computing device, the person about the at least one alert comprises dynamically outputting at least one of at least one visual alert and at least one audio alert.

5. The computer system of claim 1, wherein the at least one characteristic of the current psychological condition of the person is a stress level.

6. The computer system of claim 1, wherein the at least one characteristic of the current physiological condition of the person is a heart rate.

7. A computer-implemented method, comprising:

providing at least one wearable garment, comprising a plurality of non-invasive sensors;

i) wherein the plurality of non-invasive sensors are configured to continuously acquire, in real-time, a plurality of biosignals from a person wearing the at least one wearable garment;

ii) wherein the plurality of biosignals are representative of heart rate variability (HRV), electrodermal activity (EDA), and motor movement;

iii) wherein the at least one wearable garment is configured to wirelessly transmit the plurality of biosignals to at least one portable computing device associated with the person wearing the at least one wearable garment;

programming the at least one portable computing device with a software to be stored on a non-transient computer readable medium;

wherein, upon execution of the software, the at least one portable computing device is at least configured to;

i) receiving, in real-time, a current set of the plurality of biosignals which are representative of a current value of at least one power spectral component of the heart rate variability (current HRV value), a current value of the electrodermal activity (current EDA value), and current motor movement of the person;

ii) dynamically calculating, in real-time, based on the current set of the plurality of biosignals, the current HRV value and the current EDA value;

iii) dynamically determining, in real-time, based on the current set of the plurality of biosignals, the current motor movement of the person;

iv) dynamically comparing, in real-time,

1) the current HRV value to at least a population historical HRV value of a population of people, wherein each person of the population of people has at least one characteristic associated with at least one of a current psychological condition of the person and a current physiological condition of the person and wherein the at least one characteristic of the current physiological condition of the person is dependent on a food intake of the person;

2) the current EDA value to at least a population historical EDA value of the population of people; and

3) the current motor movement of the person to a historical motor movement of the person at the particular time period;

v) based on the comparing, dynamically determining, in real-time, a presence of at least one health-related condition;

vi) dynamically generating, in real-time, at least one alert when the presence of the at least one health-related condition has been determined; and

vii) at least one of;

1) dynamically appraising, via the at least one portable computing device, the person about the at least one alert, and

2) dynamically and wirelessly transmitting, in real-time, the at least one alert to at least one of;

a first electronic device associated with the at least one family member, a second electronic device associated with at least one medical practitioner, or any combination thereof.

8. The method of claim 7, wherein the at least one portable computing device is further configured to dynamically transmitting, in real-time, the at least one alert to a third electronic device;

and therein the third electronic device is configured to reside in the at least one wearable garment.

9. The method of claim 7, wherein the first electronic device and the second electronic device are portable electronic devices.

10. The method of claim 7, wherein the dynamically appraising, via the at least one portable computing device, the person about the at least one alert comprises dynamically outputting at least one of at least one visual alert and at least one audio alert.

11. The method of claim 7, wherein the at least one characteristic of the current psychological condition of the person is a stress level.

12. The method of claim 7, wherein the at least one characteristic of the current physiological condition of the person is a heart rate.