Monitoring uterine activity

• US 9,968,291 B2
• Filed: 07/06/2010
• Issued: 05/15/2018
• Est. Priority Date: 07/06/2009
• Status: Active Grant

• Current Assignee: Monica Healthcare Limited (General Electric Company)
• Original Assignee: Monica Healthcare Limited (General Electric Company)
• Inventors: Hayes-Gill, Barrie Robert, Pieri, Jean-Francois
• Primary Examiner(s): ABOUELELA, MAY A
• Application Number:
  US13/382,273
• Publication Number:
  US 20120150010A1
• Time in Patent Office: 2,870 Days
• Field of Search: 600372, 600382, 600587, 600591, 600547, 600300, 600301, 600595, 606119
• CPC Class Codes: A61B 5/02411 of foetuses
• CPC Class Codes: A61B 5/11 Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb for measuring pulse A61B5/02 ;A61B5/1038 takes precedence; motion detection to correct for motion artifacts in physiological signals A61B5/721
• CPC Class Codes: A61B 5/391 of genito-urinary organs
• CPC Class Codes: A61B 5/4343 Pregnancy and labour monitoring, e.g. for labour onset detection
• CPC Class Codes: A61B 5/4356 Assessing uterine contractions A61B5/033 takes precedence
• CPC Class Codes: A61B 5/4362 Assessing foetal parameters
• CPC Class Codes: A61B 5/721 using a separate sensor to detect motion or using motion information derived from signals other than the physiological signal to be measured

Abstract

An apparatus and method for detecting uterine activity uses cutaneous electrodes on the maternal abdomen to obtain electrophysiological signals that can be used to obtain fetal and maternal heart rate. The apparatus includes a first input for receiving electrical signals from the cutaneous electrodes and a second input for receiving movement signals indicative of a movement of the maternal body from a movement detector. A signal processor separates a uterine electromyogram signal from fetal and maternal heart rate signals and filters out motion artifacts from the electromyogram using the movement signals. An output presents electrohysterogram (EHG) data from the uterine electromyogram signal.

Claims

1. Apparatus for detecting uterine activity comprising:

a plurality of cutaneous electrodes, the cutaneous electrodes configured for attachment to a maternal abdominal wall;

a first input configured to receive electrical signals from the cutaneous electrodes;

a movement sensor configured to provide movement signals indicative of a physical acceleration of a maternal body or abdomen;

a second input configured to receive the movement signals from the movement sensor;

an output;

a signal processor coupled to the first and second inputs and the output, the signal processor configured to separate a uterine electromyogram signal from fetal and maternal heart rate signals in the electrical signals received at the first input and to filter maternal motion artefacts from the uterine electromyogram signal using the movement signals received at the second input by attenuating the uterine electromyogram signal as a function of a magnitude of the movement signals, the signal processor being further configured to filter fetal motion artefacts from the uterine electromyogram signal by removal of peak excursions in the uterine electromyogram signal based on an average value of the uterine electromyogram signal; and

the output configured to present electrohysterogram (EHG) data from the filtered uterine electromyogram signal.

2. The apparatus of claim 1 wherein the signal processor is configured to attenuate or filter the uterine electromyogram signal as a non-linear function of the magnitude of the movement signals.

3. The apparatus of claim 1 in which the signal processor includes an EHG detection circuit with a bandwidth between approximately 0.2 Hz and 150 Hz.

4. The apparatus of claim 1 in which the signal processor includes a bandpass filter between 0.2 Hz and 0.9 Hz.

5. The apparatus of claim 1 in which the signal processor is configured to remove baseline wander from the electrohysterogram data, by determining for every specific data point a minimum value from a set of preceding data points to act as a baseline value and subtracting that baseline value from the specific data point.

6. The apparatus of claim 1 in which the signal processor is further configured to scale the EHG data with a non-linear function to provide a measure of contraction strength.

7. The apparatus of claim 6 in which the non-linear function is configured to return the EHG data that correlates with an intrauterine pressure, wherein the intrauterine pressure is measured using an intrauterine pressure catheter.

8. The apparatus of claim 1 in which at least one of the cutaneous electrodes incorporates a movement sensor.

9. The apparatus of claim 8 in which the movement sensor detects movement or acceleration in three dimensions.

10. The apparatus of claim 1 in which the movement signals are derived from an amplitude of maternal ECG as a function of time, the signal processor being configured to measure maternal ECG and determine movement of the maternal body therefrom.

11. The apparatus for detecting uterine activity of claim 1, wherein the signal processor is configured to filter the fetal motion artefacts from the uterine electromyogram signal.

12. The apparatus of claim 1, wherein the movement sensor comprises an accelerometer or gyro or inertial motion sensor.

13. A method of detecting uterine activity comprising the steps of:

generating electrical signals using cutaneous electrodes disposed on a maternal abdomen;

obtaining movement signals using a movement sensor to provide movement signals indicative of a physical acceleration of a maternal body or abdomen;

separating, using a signal processor, a uterine electromyogram signal from fetal and maternal heart rate signals in said generated electrical signals and filtering, using the signal processor, maternal motion artefacts from the uterine electromyogram signal using the movement signals by attenuating the uterine electromyogram signal as a function of a magnitude of the movement signals;

filtering, using the signal processor, fetal motion artefacts from the uterine electromyogram signal by removal of peak excursions in the uterine electromyogram signal based on an average value of the uterine electromyogram signal; and

providing, using the signal processor, electrohysterogram (EHG) data from the filtered uterine electromyogram signal.

14. The method of claim 13 further including the steps of:

attaching a first electrode to a symphis pubis region of the maternal abdomen;

attaching a second electrode to the maternal abdomen, between a line 5 cm below a uterus fundus and a line of the uterus fundus or between a line at a level of a navel or umbilicus and the line of the uterus fundus;

generating, by the signal processor, said electrical signals from said first and second electrodes.

15. The method of claim 13 further including the step of obtaining said movement signals from a movement transducer or sensor.

16. The method of claim 13 further including the step of obtaining said movement signals from said electrical signals generated by the cutaneous electrodes.

17. Apparatus for collecting fetal heart rate data and uterine activity data, comprising:

a plurality of cutaneous electrodes arranged to be located on an abdomen of a pregnant mother in use;

signal inputs configured to receive electrical signals-from said electrodes in use, the electrical signals comprising electrophysiological signals indicative of fetal heart rate and uterine activity;

a signal processor configured to process said received electrical signals to generate separate data signals of the fetal heart rate and uterine activity;

the signal processor arranged to extract at least one fetal heart rate parameter and at least one uterine activity parameter from said data signals; and

an output coupled to the signal processor, the apparatus configured to provide to said output a graphical or tabular form of said at least one fetal heart rate parameter and said at least one uterine activity parameter for timed frames;

wherein the signal processor is further configured to obtain a measure of root mean square of successive differences in time series of beat-to-beat time intervals and the apparatus is configured to provide to said output the measure in a graphical or tabular form.

18. The apparatus of claim 17 in which:

the fetal heart rate parameter is selected to include at least one of baseline heart rate, number of heart rate accelerations and number of heart rate decelerations; and

the uterine activity parameter is selected to include at least one of contraction time location, contraction duration, contraction strength and time occurrence from a fetal heart rate deceleration.

19. The apparatus of claim 17 configured to provide at said output timed frames having a duration of at least 30 minutes and long-term collection and output of said parameters over a period of at least one hour.

20. The apparatus of claim 17, wherein the apparatus is configured to provide said measure of root mean square of successive differences in a graphical or tabular form for timed frames to provide an indication of a correlation between time occurrence of the measure of root mean square of successive differences and a uterine contraction.

21. The apparatus of claim 17, wherein the signal processor configured to obtain a maternal heart rate parameter from the electrical signals from the cutaneous electrodes and the output in graphical or tabular form comprises the maternal heart rate parameter.

22. The apparatus of claim 21 wherein the signal processor is further configured to obtain a measure for the maternal heart rate of root mean square of successive differences in time series of beat-to-beat intervals.

23. The apparatus of claim 17, wherein the signal processor separate the at least one fetal heart rate parameter and at least one uterine activity parameter from common the electric signals from the cutaneous electrodes.

24. The apparatus of claim 17, wherein the signal processor is further configured to obtain time averaged fetal heart rate parameter data and the output in graphical or tabular form further comprises said time averaged fetal heart rate parameter data.

25. The apparatus of claim 17, wherein the cutaneous electrodes include a movement sensor and the signal processor is arranged to filter maternal motion artefacts from said electrical signals.