Analyte signal processing device and methods

• US 9,968,302 B2
• Filed: 04/04/2016
• Issued: 05/15/2018
• Est. Priority Date: 08/31/2009
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Fennell, Martin J.
• Primary Examiner(s): LAU, TUNG S
• Application Number:
  US15/090,610
• Publication Number:
  US 20160213327A1
• Time in Patent Office: 771 Days
• Field of Search: None
• CPC Class Codes: A61B 2560/0209 adapted for power saving
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/7228 Signal modulation applied to the input signal sent to patient or subject; demodulation to recover the physiological signal modulation H03C
• CPC Class Codes: G01N 15/01 specially adapted for biological cells, e.g. blood cells investigating sedimentation of particle suspensions in blood G01N15/05
• CPC Class Codes: G01N 15/0606 by collecting particles on a support
• CPC Class Codes: G01N 15/0656 using electric, e.g. electrostatic methods or magnetic methods by investigating individual particles G01N15/1031, G01N15/12

Abstract

Methods and devices for determining a measurement time period, receiving a plurality of signals associated with a monitored analyte level during the determined measurement time period from an analyte sensor, modulating the received plurality of signals to generate a data stream over the measurement time period, and accumulating the generated data stream to determine an analyte signal corresponding to the monitored analyte level associated with the measurement time period are provided. Systems and kits are also described.

Claims

1. A method, comprising:

determining a measurement time period;

generating a plurality of clock signals using a clock;

receiving a plurality of analog signals associated with a monitored analyte level during the determined measurement time period from an analyte sensor, the measurement time period establishing a maximum signal resolution associated with the clock and a sigma-delta modulator as a function of analog to digital conversion time to obtain a higher signal resolution;

modulating the received plurality of analog signals using the sigma-delta modulator to generate a frequency data stream over the measurement time period based on the received plurality of analog signals by synchronizing each of the received plurality of analog signals to a corresponding one of the generated plurality of clock signals, and filtering one or more signal artifacts from the frequency data stream over the measurement time period, the one or more signal artifacts including a signal transient; and

accumulating the generated frequency data stream to determine an analyte signal corresponding to the monitored analyte level associated with the measurement time period.

2. The method of claim 1, wherein the frequency data stream includes one or more pulses each associated with a respective one of the generated plurality of clock signals.

3. The method of claim 1, further comprising transmitting data associated with the monitored analyte level over a communication connection.

4. The method of claim 1, wherein the analyte sensor includes a glucose sensor.

5. The method of claim 1, wherein the received plurality of analog signals are current signals.

6. The method of claim 1, further comprising averaging the accumulated generated frequency data stream over the measurement time period.

7. The method of claim 1, wherein the analyte sensor comprises a plurality of electrodes including a working electrode comprising an analyte-responsive enzyme bonded to a polymer disposed on the working electrode.

8. The method of claim 1, wherein the analyte sensor comprises a plurality of electrodes including a working electrode comprising a mediator bonded to a polymer disposed on the working electrode.

9. The method of claim 3, wherein the communication connection includes an RF communication connection.

10. The method of claim 3, wherein the communication connection includes one or more of a wired communication link or a wireless communication link.

11. The method of claim 4, wherein the glucose sensor includes at least one working electrode in signal communication with an analyte sensor interface electronics.

12. The method of claim 7, wherein the analyte-responsive enzyme is chemically bonded to the polymer.

13. The method of claim 7, wherein the working electrode further comprises a mediator.

14. The method of claim 8, wherein the mediator is chemically bonded to the polymer.

15. The method of claim 8, wherein the mediator is crosslinked with the polymer.

16. The method of claim 11, wherein the working electrode of the sensor comprises one of carbon or gold.