Treatment and prevention of bone loss using resolvins
First Claim
1. A method of growing bone in a vertebrate subject suffering from bone loss as a result of periodontal disease, the method comprising a step of topically administering to the surface area of the bone under treatment of the subject an effective amount of Resolvin D1, wherein the method results in an increase of bone mass, an increase of bone density, or a combinations thereof.
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Abstract
The invention provides new methods for inducing or promoting bone growth and/or for reducing or preventing bone deterioration in a mammal subject. The inventive methods generally comprise administering to the subject an effective amount of a resolving. In particular, the inventive methods may be useful for treating or preventing conditions associated with bone degradation, deterioration or degeneration such as periodontal disease, osteoarthritis, and metastatic bone disease and osteolytic bone disease. Pharmaceutical compositions and kits comprising at least one resolving are also provided that can be used to performed the inventive methods.
102 Citations
6 Claims
- 1. A method of growing bone in a vertebrate subject suffering from bone loss as a result of periodontal disease, the method comprising a step of topically administering to the surface area of the bone under treatment of the subject an effective amount of Resolvin D1, wherein the method results in an increase of bone mass, an increase of bone density, or a combinations thereof.
Specification