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Treatment and prognostic monitoring of non-cancerous proliferation disorders using hedgehog pathway inhibitors

  • US 9,968,600 B2
  • Filed: 01/31/2017
  • Issued: 05/15/2018
  • Est. Priority Date: 04/17/2013
  • Status: Active Grant
First Claim
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1. A method for treating a non-cancerous proliferation disorder in a subject, comprising orally administering a composition comprising a Hedgehog pathway (HhP) inhibitor to the subject, wherein the HhP inhibitor comprises itraconazole, or a pharmaceutically acceptable salt prodrug, stereoisomer, or active metabolite thereof, wherein:

  • (a) the composition is orally administered in an effective amount to achieve a plasma trough level of at least about 1,000 ng/mL of the HhP inhibitor;

    or (b) the composition is orally administered at a dose in the range of 100 mg to 600 mg HhP inhibitor per day.

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