Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
First Claim
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1. A method of processing red blood cells (RBCs) comprising:
- filtering a flushing gas source through a gas circulation device to generate sterile flushing gas, said gas circulation device comprising, in fluid communication with each other;
a flushing gas source providing said flushing gas;
a gas outlet manifold;
a first gas sterilization filter;
a second gas sterilization filter;
one or more gas sensor assemblies;
a gas inlet manifold; and
a controller,wherein said one or more gas sensor assemblies are selected from the group consisting of an oxygen sensor, an oxygen partial pressure sensor, a carbon dioxide sensor, a carbon dioxide partial pressure sensor, and combinations thereof;
providing said sterile flushing gas to an oxygen or oxygen and carbon dioxide depletion (OCDD) device; and
flowing said RBCs through said OCDD device to remove oxygen or oxygen and carbon dioxide from said RBCs, producing oxygen or oxygen and carbon dioxide reduced red blood cells.
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Abstract
A portable assembly for processing red blood cells RBCs including a disposable blood collection set including a blood bag, an anaerobic storage bag and an oxygen and/or oxygen and carbon dioxide depletion device disposed between the blood collection bag and anaerobic storage bag. The portable assembly further provides for a gas circulation device in fluid communication with the oxygen or oxygen and carbon dioxide depletion device, The gas circulation device includes a pressure source that is able circulate flushing gas through the depletion device as RBCs pass from the blood collection bag, through the depletion device and into the anaerobic storage bag.
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Citations
20 Claims
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1. A method of processing red blood cells (RBCs) comprising:
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filtering a flushing gas source through a gas circulation device to generate sterile flushing gas, said gas circulation device comprising, in fluid communication with each other; a flushing gas source providing said flushing gas; a gas outlet manifold; a first gas sterilization filter; a second gas sterilization filter; one or more gas sensor assemblies; a gas inlet manifold; and a controller, wherein said one or more gas sensor assemblies are selected from the group consisting of an oxygen sensor, an oxygen partial pressure sensor, a carbon dioxide sensor, a carbon dioxide partial pressure sensor, and combinations thereof; providing said sterile flushing gas to an oxygen or oxygen and carbon dioxide depletion (OCDD) device; and flowing said RBCs through said OCDD device to remove oxygen or oxygen and carbon dioxide from said RBCs, producing oxygen or oxygen and carbon dioxide reduced red blood cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification