Method for improving measurement accuracy and devices and systems related thereto
First Claim
Patent Images
1. A meter for measuring hematocrit of a sample, the meter configured for insertion of a sensor comprising a sample chamber comprising a first electrode, a second electrode, and a third electrode, and comprising:
- a memory comprising instructions stored therein and coupled to a processor for executing the instructions stored in the memory of the meter, wherein the instructions, when executed, cause the processor to;
determine fill-time by measuring time elapsed between detecting a signal between the first electrode and the second electrode and another signal between the first electrode and the third electrode, wherein the fill-time is related to hematocrit of the sample;
measure a first signal at the second electrode after the sample chamber is filled with the sample, wherein the first signal is independent of the analyte concentration and is related to hematocrit of the sample;
measure a second signal at the third electrode, wherein the second signal is related to hematocrit of the sample;
derive, by using the processor executing instructions stored in the memory, a first hematocrit value, a second hematocrit value and a third hematocrit value of the property using the full-time, the first signal, and the second signal, respectively;
compare the first, second, and third hematocrit values to determine whether one of the values is an outlier; and
calculate a single hematocrit value of the property based on at least two of the first, second, and third hematocrit values that are in agreement.
1 Assignment
0 Petitions
Accused Products
Abstract
The present disclosure relates to methods and devices for providing accurate measurement of a property of a sample. The method comprises obtaining a plurality of independent measurements of the property. The plurality of values of the property of the sample obtained by the plurality of independent measurements is compared to determine whether one or more of the values is an outlier.
-
Citations
22 Claims
-
1. A meter for measuring hematocrit of a sample, the meter configured for insertion of a sensor comprising a sample chamber comprising a first electrode, a second electrode, and a third electrode, and comprising:
a memory comprising instructions stored therein and coupled to a processor for executing the instructions stored in the memory of the meter, wherein the instructions, when executed, cause the processor to; determine fill-time by measuring time elapsed between detecting a signal between the first electrode and the second electrode and another signal between the first electrode and the third electrode, wherein the fill-time is related to hematocrit of the sample; measure a first signal at the second electrode after the sample chamber is filled with the sample, wherein the first signal is independent of the analyte concentration and is related to hematocrit of the sample; measure a second signal at the third electrode, wherein the second signal is related to hematocrit of the sample; derive, by using the processor executing instructions stored in the memory, a first hematocrit value, a second hematocrit value and a third hematocrit value of the property using the full-time, the first signal, and the second signal, respectively; compare the first, second, and third hematocrit values to determine whether one of the values is an outlier; and calculate a single hematocrit value of the property based on at least two of the first, second, and third hematocrit values that are in agreement. - View Dependent Claims (2, 3, 4)
-
5. A system for determining concentration of an analyte in a sample, the system comprising an analyte measurement instrument and an analyte sensor,
the analyte sensor comprising a sample chamber comprising a first electrode, a second electrode, and a third electrode; - an enzyme responsive to the analyte and a redox mediator;
the analyte measurement instrument comprising a memory comprising instructions stored therein and coupled to a processor for executing instructions stored in the memory of the instrument, wherein the instructions, when executed, cause the processor to; determine fill-time by measuring time elapsed between detecting a signal between the first electrode and the second electrode and another signal between the first electrode and the third electrode, wherein the fill-time is related to hematocrit of the sample; measure a first signal at the second electrode after the sample chamber is filled with the sample, wherein the first signal is independent of the analyte concentration and is related to hematocrit of the sample; measure an analyte related signal at the second electrode after measuring the first signal; measure a second signal at the third electrode after measuring the analyte related signal, wherein the second signal is related to hematocrit of the sample; derive first, second, and third hematocrit values of the sample using the fill-time, the first signal, and the second signal; compare the first, second, and third hematocrit values of the sample; calculate a single hematocrit value based on at least two of the first, second and third hematocrit values when the at least two of the first, second, and third hematocrit values are in agreement; determine concentration of the analyte; and correct the concentration of the analyte according to the single hematocrit value. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- an enzyme responsive to the analyte and a redox mediator;
-
17. A system for determining analyte concentration of a sample, the system comprising an analyte sensor and a meter,
the analyte sensor comprising a sample chamber comprising a reference/counter electrode, a working electrode, a trigger electrode, an enzyme responsive to the analyte, and a redox mediator; -
the meter comprising a processor for executing instructions stored in a memory of the meter, wherein the memory comprising instructions stored therein is coupled to the processor, wherein the instructions, when executed, cause the processor to; determine fill-time by measuring time elapsed between detecting a signal between the reference/counter electrode and the working electrode and another signal between the reference/counter electrode and the trigger electrode, wherein the fill-time is related to hematocrit of the sample; disconnect the reference/counter electrode from the working electrode and from the trigger electrode after the sample chamber is substantially filled with the sample; reconnect the reference/counter electrode to the working electrode and the trigger electrode; measure a first signal at the working electrode, wherein the first signal is independent of the analyte concentration and is related to hematocrit of the sample; measure an analyte related signal at the working electrode after measuring the first signal; measure a second signal at the trigger electrode after measuring the analyte related signal, wherein the second signal is related to hematocrit of the sample; derive first, second, and third hematocrit values of the sample using the fill-time, the first signal, and the second signal; compare the first, second, and third hematocrit values of the sample; calculate a single hematocrit value based on at least two of the first, second and third hematocrit values when the at least two of the first, second, and third hematocrit values are in agreement; determine concentration of the analyte; and correct the concentration of the analyte according to the single hematocrit value. - View Dependent Claims (18, 19, 20, 21, 22)
-
Specification