Methods, systems, and devices for electrode capacitance calculation and application

• US 9,970,893 B2
• Filed: 04/28/2016
• Issued: 05/15/2018
• Est. Priority Date: 04/28/2016
• Status: Active Grant

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Inventors: Morgan, Wayne A.
• Primary Examiner(s): Le, Son
• Assistant Examiner(s): Zakaria, Akm
• Application Number:
  US15/141,021
• Publication Number:
  US 20170315076A1
• Time in Patent Office: 747 Days
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/7221 Determining signal validity, reliability or quality A61B5/7207 and A61B5/7217 take precedence
• CPC Class Codes: G01N 27/22 by investigating capacitance
• CPC Class Codes: G01N 27/3271 Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001
• CPC Class Codes: G01N 33/48707 by electrical means G01N33/49, G01N33/493 take precedence
• CPC Class Codes: G01N 33/49 Blood chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80
• CPC Class Codes: G01R 17/00 Measuring arrangements involving comparison with a reference value, e.g. bridge
• CPC Class Codes: G01R 19/0084 measuring voltage only all subgroups of G01R19/00 take precedence
• CPC Class Codes: G01R 27/2605 Measuring capacitance capacitive sensors G01D5/24

Abstract

The double layer capacitance of a working electrode of a sensor may be measured with minimal disruption to the sensor equilibrium by open circuiting the working electrode and measuring the voltage drift on a periodic, or as-needed, basis. The values of the double layer capacitance may be monitored over time to determine, e.g., sensor age and condition.

Claims

1. A method for real-time monitoring of a subcutaneous or implantable glucose sensor for measuring the level of glucose in a body of a user, said sensor including physical sensor electronics, a microcontroller, and a working electrode (WE) in an electrical circuit that provides an input current to the working electrode, the method comprising:

(a) measuring, by said sensor electronics, a first current level for the working electrode current;

(b) after measuring said first current level, open circuiting, by said microcontroller, the working electrode by discontinuing said input current to the working electrode;

(c) after open circuiting the working electrode, measuring, by said sensor electronics, a first WE voltage value;

(d) after a predefined time interval after measurement of said first WE voltage value, measuring, by said sensor electronics, a second WE voltage value;

(e) calculating a WE voltage difference between said first and second WE voltage values and determining whether said difference exceeds a threshold WE-voltage difference value; and

(f) if said WE voltage difference exceeds said threshold output-voltage difference value, calculating the working electrode'"'"'s capacitance by the relation C=(I)/(dV/dT), wherein I is the first current level, dV is the difference between said first and second WE voltage values, and dT is the difference between respective points in time when said first and second WE voltage values were measured,

wherein, if said WE voltage difference is less than or equal to said threshold WE-voltage difference value, the method further comprises;

(1) waiting for an amount of time equal to said predefined time interval and measuring an additional WE voltage value;

(2) calculating an updated WE voltage difference as the difference between said first WE voltage value and said additional WE voltage value;

(3) determining whether said updated WE voltage difference exceeds said threshold WE-voltage difference value; and

(4) if said updated WE voltage difference exceeds said threshold WE-voltage difference value, calculating the working electrode'"'"'s capacitance by the relation C=(I)/(dV/dT), wherein I is the first current level, dV is the value of said updated WE voltage difference, and dT is the difference between respective points in time when said first and additional WE voltage values were measured;

wherein, if said updated WE voltage difference is less than or equal to said threshold WE-voltage difference value, the method further includes, prior to step (4), iteratively repeating steps (1)-(3) until said updated WE voltage difference exceeds said threshold WE-voltage difference value; and

wherein said iterative repetition cannot occur beyond a time-out window.

2. The method of claim 1, wherein, upon expiration of said time-out window, no further WE voltage measurement is taken, and the working electrode'"'"'s capacitance is calculated by the relation C=(I)/(dV/dT), wherein I is the first current level, dV is the difference between the first WE voltage value and the last-measured WE voltage value, and dT is the difference between respective points in time when said first WE voltage value and said last-measured WE voltage value were measured.

3. The method of claim 2, further including resuming said input current to the working electrode after expiration of said time-out window.

4. The method of claim 2, wherein said time-out window has a duration of between about 25 and about 40 seconds.

5. The method of claim 2, wherein said calculation of the working electrode'"'"'s capacitance is repeated about once every 5-15 minutes.

6. The method of claim 1, wherein said dT is between about 7 seconds and about 15 seconds long.

7. The method of claim 1, wherein, in step (c), the first WE voltage value is measured within about 1 second of open circuiting the working electrode.

8. The method of claim 1, wherein, in step (d), said predefined time interval lasts for about 1-2 seconds.

9. A method for determining whether a used subcutaneous or implantable glucose sensor is being used by a user for measuring the level of glucose in the user'"'"'s body, said sensor including physical sensor electronics, a microcontroller, and a working electrode (WE) in an electrical circuit that provides an input current to the working electrode, the method comprising:

(a) measuring, by said sensor electronics, a first current level for the working electrode current;

(b) after measuring said first current level, open circuiting, by said microcontroller, the working electrode by discontinuing said input current to the working electrode;

(c) after open circuiting the working electrode, measuring, by said sensor electronics, a first WE voltage value;

(d) after a predefined time interval after measurement of said first WE voltage value, measuring, by said sensor electronics, a second WE voltage value;

(e) calculating the working electrode'"'"'s capacitance based on said first and second WE voltage values;

(f) periodically repeating steps (a) (e) and monitoring the working electrode'"'"'s capacitance over a predetermined time interval, wherein said predetermined time interval is between about 15 and about 30 minutes; and

(g) determining that the sensor is a used sensor if the change in the working electrode'"'"'s capacitance over said predetermined time interval is less than a threshold capacitance value, wherein said threshold capacitance value is between about 3% and about 5%.

10. The method of claim 9, wherein step (e) comprises:

calculating a WE voltage difference between said first and second WE voltage values and, if said WE voltage difference exceeds a threshold WE-voltage difference value, calculating the working electrode'"'"'s capacitance by the relation C=(I)/(dV/dT), wherein I is the first current level, dV is the difference between said first and second WE voltage values, and dT is the difference between respective points in time when said first and second WE voltage values were measured.

11. The method of claim 10, wherein, if said WE voltage difference does not exceed said threshold WE-voltage difference value, the method further comprises measuring a subsequent WE voltage value, calculating an updated WE voltage difference as the difference between said first WE voltage value and said subsequent WE voltage value, and if said updated WE voltage difference exceeds said threshold WE-voltage difference value, calculating the working electrode'"'"'s capacitance by the relation C=(I)/(dV/dT), wherein I is the first current level, dV is the value of said updated WE voltage difference, and dT is the difference between respective points in time when said first and subsequent WE voltage values were measured.

12. The method of claim 11, wherein, if said updated WE voltage difference does not exceed said threshold WE-voltage difference value, the method further includes iteratively repeating said measurement of a subsequent WE voltage value and calculation of an updated WE voltage difference until said updated WE voltage difference exceeds said threshold WE-voltage difference value.

13. The method of claim 12, wherein said iterative repetition cannot occur beyond a time-out window.

14. The method of claim 13, wherein, upon expiration of said time-out window, no further WE voltage measurement is taken, and the working electrode'"'"'s capacitance is calculated by the relation C=(I)/(dV/dT), wherein I is the first current level, dV is the difference between the first WE voltage value and the last-measured WE voltage value, and dT is the difference between respective points in time when said first WE voltage value and said last-measured WE voltage value were measured.

15. The method of claim 14, further including resuming said input current to the working electrode after expiration of said time-out window.

16. The method of claim 14, wherein said time-out window has a duration of between about 25 and about 40 seconds.

17. The method of claim 9, wherein, in step (c), the first WE voltage value is measured within about 1 second of open circuiting the working electrode.

18. The method of claim 9, wherein, in step (d), said predefined time interval lasts for about 1-2 seconds.