Accelerated magnetic resonance thermometry

• US 9,971,003 B2
• Filed: 03/02/2012
• Issued: 05/15/2018
• Est. Priority Date: 03/17/2011
• Status: Active Grant

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Khler, Max Oskar, Vahala, Erkki Tapani, Nurmilaukas, Kirsi Ilona
• Primary Examiner(s): Chen, Tse
• Assistant Examiner(s): Hoffman, Joanne
• Application Number:
  US14/005,060
• Publication Number:
  US 20140005523A1
• Time in Patent Office: 2,265 Days
• CPC Class Codes: A61B 18/02 by cooling, e.g. cryogenic techniques devices for cooling specific reflex points of the body within cell-life limits A61H39/06
• CPC Class Codes: A61B 18/12 by passing a current through the tissue to be heated, e.g. high-frequency current
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61B 2018/00791 Temperature
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61N 2007/0065 Concave transducers
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: G01R 33/4804 Spatially selective measurement of temperature or pH
• CPC Class Codes: G01R 33/4808 Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
• CPC Class Codes: G01R 33/4814 MR combined with ultrasound

Abstract

A medical apparatus (300, 400, 500, 600) comprising a magnetic resonance imaging system (302). The medical apparatus further comprises a memory (332) storing machine readable instructions (352, 354, 356, 358, 470, 472, 474) for execution by a processor (326). Execution of the instructions causes the processor to acquire (100, 202) spectroscopic magnetic resonance data (334). Execution of the instructions further cause the processor to calculate (102, 204) a calibration thermal map (336) using the spectroscopic magnetic resonance data. Execution of the instructions further causes the processor to acquire (104, 206) baseline magnetic resonance thermometry data (338). Execution of the instructions further causes the processor to repeatedly acquire (106, 212) magnetic resonance thermometry data (340). Execution of the instructions further cause the processor to calculate (108, 214) a temperature map (351) using the magnetic resonance thermometry data, the calibration thermal map, and the baseline magnetic resonance thermometry data.

Claims

1. An apparatus comprising:

a magnetic resonance imaging system, the magnetic imaging system comprising;

a magnet,

magnetic gradient field coils, and

a radio frequency coil;

a processor for controlling the apparatus; and

a memory storing machine readable instructions for execution by the processor, wherein execution of the instructions causes the processor;

to control the magnetic resonance imaging system to generate a spectroscopic pulse sequence and in response thereto to acquire spectroscopic magnetic resonance data for an imaging zone,

to produce a calibration thermal map of the imaging zone from the acquired spectroscopic magnetic resonance data,

to control the magnetic resonance imaging system to generate a magnetic resonance thermometry pulse sequence and in response thereto to acquire baseline magnetic resonance thermometry data for the imaging zone, and

to repeatedly;

control the magnetic resonance imaging system to generate the magnetic resonance thermometry pulse sequence and in response thereto to acquire additional magnetic resonance thermometry data for the imaging zone, and produce a temperature map of the imaging zone from the calibration thermal map, the baseline magnetic resonance thermometry data, and the additional magnetic resonance thermometry data.

2. The apparatus of claim 1, further comprising a temperature treatment system for treating a target volume of a subject, wherein during acquisition of the additional magnetic resonance thermometry data execution of the instructions further causes the processor to:

generate temperature treatment system commands in accordance with the temperature map;

wherein the temperature treatment system commands cause the temperature treatment system to treat the target volume; and

send the temperature treatment system commands to the temperature treatment system.

3. The apparatus of claim 2, wherein execution of the instructions further causes the processor to:

generate pause commands which cause the temperature treatment system to pause treatment of the target zone for a predetermined period of time;

send the pause commands to the temperature treatment system;

re-acquire the spectroscopic magnetic resonance data during the predetermined period of time;

re-calculate the calibration thermal map using the spectroscopic magnetic resonance data; and

re-acquire the baseline magnetic resonance thermometry data.

4. The apparatus of claim 2, wherein the temperature treatment system is chosen from the group consisting of a high intensity focused ultrasound system, a radio-frequency tissue treating system, microwave applicator, a cryo-ablator, and a laser.

5. The apparatus of claim 2, wherein the temperature treatment system commands are generated in accordance with any one of the following:

a treatment plan, the temperature map, and combinations thereof.

6. The apparatus of claim 1, wherein execution of the instructions further cause the processor to identify voxels of the calibration thermal map which lack spectroscopic thermal magnetic resonance data for calculating the thermal map, wherein execution of the instructions further causes the processor to extrapolate the thermal map into the identified voxels.

7. The apparatus of claim 6, wherein the thermal map is extrapolated and/or refined using a thermal model of the subject.

8. The apparatus of claim 7, wherein execution of the instructions further causes the processor to construct the thermal model using the spectroscopic magnetic resonance data.

9. The apparatus of claim 7, further comprising a temperature treatment system for treating a target volume of a subject, wherein execution of the instructions further causes the processor to treat the target volume during acquisition of the magnetic resonance thermometry data, and wherein the treatment of the target volume is modeled by the thermal model.

10. The apparatus of claim 6, wherein the thermal map is extrapolated by interpolating the temperature in the identified voxels.

11. The apparatus of claim 1, wherein the baseline magnetic resonance thermometry data and the additional magnetic resonance thermometry data is chosen from the group consisting of proton density data, T1 relaxation time data, T2 relaxation time data, T2-star relaxation time data, diffusion coefficient data, proton resonance frequency shift data, and combinations thereof.

12. The apparatus of claim 1, wherein spectroscopic magnetic resonance data is descriptive of the proton-resonance frequency shift of multiple resonance peaks.

13. The apparatus of claim 1, wherein acquiring the spectroscopic magnetic resonance data includes determining a difference between a first resonance frequency peak for water and a reference resonance frequency peak which remains substantially constant with temperature.

14. The apparatus of claim 13, wherein acquiring the baseline magnetic resonance thermometry data and the additional magnetic resonance thermometry data includes determining a temperature change in the imaging zone from a phase change between two phase images of the imaging zone at a given echo time.

15. A method of operating an apparatus including a magnetic resonance imaging system, the method comprising:

employing the magnetic resonance imaging system to generate a spectroscopic pulse sequence and in response thereto acquiring spectroscopic magnetic resonance data for an imaging zone;

producing a calibration thermal map of the imaging zone from the acquired spectroscopic magnetic resonance data;

employing the magnetic resonance imaging system to generate a magnetic resonance thermometry pulse sequence and in response thereto acquiring baseline magnetic resonance thermometry data for the imaging zone;

employing the magnetic resonance imaging system to repeatedly generate the magnetic resonance thermometry pulse sequence and in response thereto acquiring additional magnetic resonance thermometry data for the imaging zone; and

repeatedly producing a temperature map of the imaging zone from the calibration thermal map, the baseline magnetic resonance thermometry data, and the additional magnetic resonance thermometry data.

16. The method of claim 15, wherein acquiring the spectroscopic magnetic resonance data includes determining a difference between a first resonance frequency peak for water and a reference resonance frequency peak which remains substantially constant with temperature.

17. The method of claim 16, wherein acquiring the baseline magnetic resonance thermometry data and the additional magnetic resonance thermometry data includes determining a temperature change from a phase change between two phase images of the imaging zone at a given echo time.

18. The method of claim 15, wherein the apparatus further includes a therapy system, the method further comprising:

during acquisition of the additional magnetic resonance thermometry data, the therapy system applying heating or cooling to a target volume of a subject.

19. An apparatus, comprising:

a magnetic resonance imaging system;

a processor for controlling the apparatus; and

a memory storing machine readable instructions for execution by the processor, wherein execution of the instructions causes the processor to control the apparatus;

to perform a proton spectroscopic temperature imaging mapping of the imaging zone to obtain an absolute temperature map of the imaging zone;

subsequently to perform a series of proton resonance frequency temperature imaging mappings of the imaging zone; and

to produce a series of temperature maps of the imaging zone from the absolute temperature map of the imaging zone and the proton resonance frequency temperature imaging mappings of the imaging zone.

20. The apparatus of claim 19, further comprising a therapy system for treating a target volume of a subject, the target volume at least partly falling within the imaging zone, wherein execution of the instructions further causes the processor:

to generate therapy system commands in accordance with the temperature map; and

to send the therapy system commands to the therapy system,

wherein the therapy system commands cause the therapy system to apply one of heating and cooling to the target volume during the series of proton resonance frequency temperature imaging mappings of the imaging zone.